Content

Content - Volume 98, Issue 9

Editor's choice in this issue

INVESTIGATIVE REPORT
CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters
Fani Karagianni, Ching-Ni Njauw, Katerina P. Kypreou, Aravela Stergiopoulou, Michaela Plaka, Dorothea Polydorou, Vasiliki Chasapi, Leontios Pappas, Ioannis A. Stratigos, Gregory Champsas, Peter Panagiotou, Helen Gogas, Evangelos Evangelou, Hensin Tsao, Alexander J. Stratigos, Irene Stefanaki
Our study presents a series of Greek familial melanoma patients and evaluates CDKN2A and CDK4 variants in these patients in association with clinico-epidemiological characteristics and family prevalence of other neoplasias. The high percentage (46.2%) of CDKN2A variants among Greek melanoma-prone families highlights the value of genetic counseling and testing, while medical advice on healthy lifestyle and prompt screening for other cancers is essential. The age of at melanoma diagnosis was shifted a decade earlier in carriers of CDKN2A variants compared with CDKN2A wild­type patients, underscoring the need for intense vigilance in these individuals from a young age.
Pages: 862-866
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INVESTIGATIVE REPORT
Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo
Antony R. Young, Jessica Greenaway, Graham I. Harrison, Karl P. Lawrence, Robert Sarkany, Thierry Douki, France Boyer, Gwendal Josse, Emmanuel Questel, Camille Monteil, Ana B. Rossi
A sunscreen’s labelled SPF is determined at 2mg/cm2 skin but actual SPF depends on application thickness (see figure). This was also the case for protection against epidermal DNA photodamage with acute and repeated daily exposures of high dose solar simulated radiation (SSR). However, even at an application thickness of 0.75mg/cm2, that represents “typical” sunscreen use, there was significant protection against DNA lesions (assessed by HPLC-MS-MS) from 5 consecutive days of SSR exposure. The study supports the use of a very high SPF sunscreen in the prevention of skin cancer.
Pages: 880-887
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All articles

EDITORIAL
Changes in Editorial Board of Acta Dermato-Venereologica
Artur Schmidtchen, Anders Vahlquist
Abstract is missing (Editorial)
Page: 828
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CLINICAL REPORT
Safety Profile of Secukinumab in Treatment of Patients with Psoriasis and Concurrent Hepatitis B or C: A Multicentric Prospective Cohort Study
Hsien-Yi Chiu, Rosaline Chung-yee Hui, Yu-Huei Huang, Ruey-Yun Huang, Kai-Lung Chen, Ya-Chu Tsai, Po-Ju Lai, Ting-Shun Wang, Tsen-Fang Tsai
Safety data for secukinumab in patients with psoriasis and viral hepatitis are lacking. The aim of this study is to investigate the risk of reactivation of hepatitis B virus (HBV)/hepatitis C virus (HCV) in patients with psoriasis who are receiving secukinumab therapy. This multicentre study screened 284 patients with psoriasis with available HBV and HCV serological data and 63 patients with concu ...
Pages: 829-834
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CLINICAL REPORT
Aggressive Rare T-cell Lymphomas with Manifestation in the Skin: A Monocentric Cross-sectional Case Study
Marie-Charlotte Brüggen, Katrin Kerl, Eugenia Haralambieva, Urs Schanz, Yun-Tsan Chang, Desislava Ignatova, Reinhard Dummer, Antonio Cozzio, Wolfram Hoetzenecker, Lars E. French, Emmanuella Guenova
Rare T- or NK-cell lymphomas with cutaneous manifestation may display a highly aggressive clinical course and major diagnostic/therapeutic challenges. This report describes our experiences with different lymphomas of this rare category and the therapeutic options used. This retrospective, descriptive, monocentric, cross-sectional case study, identified 4 rare aggressive T-/NK-cell lymphomas with m ...
Pages: 835-841
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CLINICAL REPORT
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options
Emma Gardette, Philippe Moguelet, Jean-David Bouaziz, Dan Lipsker, Olivier Dereure, Francois Le Pelletier, Catherine Lok, Thierry Maisonobe, Didier Bessis, Jacqueline Conard, Camille Francès, Stéphane Barete
Livedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid vasculopathy and the efficacy of treatments. Patients enrolled had typical livedoid vasculopathy both clinically and histologically. Investigation of thrombophilia was performed. Electromyography was undertaken in the presence of symptoms suggestin ...
Pages: 842-847
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CLINICAL REPORT
Longer Duration of Untreated Psychosis is Associated with Poorer Outcomes for Patients with Delusional Infestation
Dmitry V. Romanov, Peter Lepping, Anthony Bewley, Markus Huber, Roland W. Freudenmann, Andrey Lvov, Stephen Bertel Squire, Eric O. Noorthoorn
We examined the association between the duration of untreated psychosis and outcome for patients with delusional infestation. This multi-centre international study included 211 consecutive patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at baseline and follow-up. A regression analysis showed a clear clinical a ...
Pages: 848-854
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INVESTIGATIVE REPORT
Modulation of Itch by Localized Skin Warming and Cooling
Kristen M. Sanders, Takashi Hashimoto, Kent Sakai, Tasuku Akiyama
Skin thermal changes modulate itch sensitivity. However, the mechanisms of this modulation are still unclear. Using mouse models of acute and chronic itch, we investigated whether local innocuous thermal stimulation of the skin alters itch sensitivity and if blockade of thermosensitive transient receptor potential (TRP) channels can reduce these changes. Localized thermal changes were achieved by ...
Pages: 855-861
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INVESTIGATIVE REPORT
CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters
Fani Karagianni, Ching-Ni Njauw, Katerina P. Kypreou, Aravela Stergiopoulou, Michaela Plaka, Dorothea Polydorou, Vasiliki Chasapi, Leontios Pappas, Ioannis A. Stratigos, Gregory Champsas, Peter Panagiotou, Helen Gogas, Evangelos Evangelou, Hensin Tsao, Alexander J. Stratigos, Irene Stefanaki
Approximately 5–10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correlate the mutational status with specific clinico-epidemiological characteristics. A cross-sectional study was conducted by genotyping CDKN2A/CDK4 varian ...
Pages: 862-866
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INVESTIGATIVE REPORT
Overexpression of Androgen, Oestrogen and Progesterone Receptors in Skin Lesions of Becker’s Naevus
Ping Sheng, Yun-Long Cheng, Chuan-Chuan Cai, Ya-Yun Wu, Ge Shi, Ying Zhou, Yi-Ming Fan
Becker’s naevus is androgen-dependent. The aim of this study was to investigate whether oestrogen and progesterone receptors are involved in this disorder. Immunohistochemistry showed that epidermal expression of androgen receptors, oestrogen receptors (α, β) and progesterone receptors was higher in skin lesions of Becker’s naevus than in perilesional and control skin. Androgen receptor over ...
Pages: 867-872
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INVESTIGATIVE REPORT
Genotype–Phenotype Correlations of Dystrophic Epidermolysis Bullosa in India: Experience from a Tertiary Care Centre
Vamsi K. Yenamandra, Shamsudheen K. Vellarikkal, Madhumita R. Chowdhury, Rijith Jayarajan, Ankit Verma, Vinod Scaria, Sridhar Sivasubbu, Subrata Basu Ray, Amit K. Dinda, Madhulika Kabra, Vinod K. Sharma, Gomathy Sethuraman
Recent advances in the field of genomics have seen the successful implementation of whole exome sequencing as a rapid and efficient diagnostic strategy in several genodermatoses. The aim of this study was to explore the potential of molecular studies in dystrophic epidermolysis bullosa (DEB) in India. Whole exome sequencing was performed using genomic DNA from each case of epidermolysis bullosa, f ...
Pages: 873-879
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INVESTIGATIVE REPORT
Sub-optimal Application of a High SPF Sunscreen Prevents Epidermal DNA Damage in Vivo
Antony R. Young, Jessica Greenaway, Graham I. Harrison, Karl P. Lawrence, Robert Sarkany, Thierry Douki, France Boyer, Gwendal Josse, Emmanuel Questel, Camille Monteil, Ana B. Rossi
The cyclobutane pyrimidine dimer (CPD) is a potentially mutagenic DNA photolesion that is the basis of most skin cancers. There are no data on DNA protection by sunscreens under typical conditions of use. The study aim was to determine such protection, in phototypes I/II, with representative sunscreen-user application. A very high SPF formulation was applied at 0.75, 1.3 and 2.0 mg/cm2. Unprotecte ...
Pages: 880-887
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INVESTIGATIVE REPORT
Methotrexate Exposure and Risk of Cutaneous Malignant Melanoma: No Evidence of a Dose-response Relationship
Sam Polesie, Martin Gillstedt, John Paoli, Amra Osmancevic
Methotrexate treatment has been linked with an increased risk of melanoma. However, a possible dose-response relationship with respect to methotrexate exposure and melanoma has not been addressed. The aim of the present study was to investigate whether higher accumulated doses of methotrexate correlate with an increased risk of melanoma, which would further support a possible association. A nation ...
Pages: 888-895
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SHORT COMMUNICATION
Nanostring Analysis of Skin Biopsies from Patients with Henoch-Schönlein Purpura Reveals Genes Associated with Pathology and Heterogeneity in the Disease Process
Yingrou Tan, Jackson Liang Yao Li, Bernett Teck Kwong Lee, Josephine Lum, Zacharias Aloysius Dwi Pramono, Maximilien Evrard, Michael Poidinger, Hong Liang Tey, Lai Guan Ng
Abstract is missing (Short communication)
Pages: 896-897
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SHORT COMMUNICATION
Chlamydiales Bacterial Sequences in Lesional and Healthy Skin of Patients with Parapsoriasis
Kati Hokynar, Alexander Salava, Eero Vesterinen, Antti Lauerma, Annamari Ranki, Mirja Puolakkainen
Abstract is missing (Short communication)
Pages: 898-899
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SHORT COMMUNICATION
Methotrexate for the Treatment of Recalcitrant Primary Localized Cutaneous Amyloidosis: A Case Series
Carolyn M. Stull, Hong Liang Tey, Gil Yosipovitch
Abstract is missing (Short communication)
Pages: 900-901
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SHORT COMMUNICATION
Effects of Film Dressings on Itch Hypersensitivity Using Murine Dry Skin Models
Tomoyuki Iwanaga, Mitsutoshi Tominaga, Yui Hirata, Hironori Matsuda, Tomomasa Shimanuki, Hideoki Ogawa, Kenji Takamori
Abstract is missing (Short communication)
Pages: 902-903
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SHORT COMMUNICATION
Efficacy of Oral Ruxolitinib in a Patient with Refractory Chronic Spontaneous Urticaria
Atsushi Fukunaga, Mitsuhiro Ito, Chikako Nishigori
Abstract is missing (Short communication)
Pages: 904-905
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SHORT COMMUNICATION
Alopecia Areata-like Hair Loss Accompanying Toxic Epidermal Necrolysis
Emi Mashima, Yu Sawada, Akiha Inoue, Natsuko Saito-Sasaki, Takashi Yamaguchi, Haruna Yoshioka, Shun Ohmori, Sanehito Haruyama, Manabu Yoshioka, Etsuko Okada, Motonobu Nakamura
Abstract is missing (Short Communication)
Pages: 906-907
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SHORT COMMUNICATION
A Nodular Hidradenoma of Atypical Location in Pregnancy
Chen Yao, Michael G. Swaby, Michael R. Migden, Sirunya Silapunt
Abstract is missing (Short Communication)
Pages: 908-909
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SHORT COMMUNICATION
Squamous Cell Carcinoma and Multiple Familial Trichoepitheliomas: A Recurrent Association
Anna Dubois, Tiago Mestre, Thomas Oliphant, Akhtar Husain, Neil Rajan
Abstract is missing (Short communication)
Pages: 910-911
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SHORT COMMUNICATION
Premature Aging Syndrome, Penttinen Type: Report of a Chinese Case with a PDGFRB Mutation
Zhiyong Zhang, Shuguang Zheng, Song Zheng, Yanyan Wang, Xue-Gang Xu, Xing-Hua Gao, Hong-Duo Chen
Abstract is missing (Short communication)
Pages: 912-913
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SHORT COMMUNICATION
Disfiguring Leukoderma Caused by Banned Cosmetics: A Quiz
Laura Atzori, Ramona Zanniello, Giorgia Sarais, Viviana Piras, Luca Pilloni, Myriam Zucca, Maria Angela Brundu, Franco Rongioletti
Abstract is missing (Quiz)
Pages: 914-915
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