Content

Content - Volume 97, Issue 5

Editor's choice in this issue

INVESTIGATIVE REPORT
Opioid Receptors in Psoriatic Skin: Relationship with Itch
Piotr Kupczyk, Adam Reich, Marcin Hołysz, Mariusz Gajda, Edyta Wysokińska, Anna Kobuszewska, Dmitry Nevozhay, Beata Nowakowska, Leon Strzadała, Paweł Poitr Jagodziński, Jacek C. Szepietowski
Psoriasis is an inflammatory immunogenetic skin disease, often accompanied by itch. Opioid receptors are known regulators of itch sensation in the central nervous system. In the brain, μ-opioid receptors may potentiate itch, while activation of κ-opioid receptors may reduce or even alleviate itch; however, the role of opioid receptors in itch perception in the skin is poorly understood. ...
Pages: 564-570
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CLINICAL REPORT
Gallstone Risk in Adult Patients with Atopic Dermatitis and Psoriasis: Possible Effect of Overweight and Obesity
Alexander Egeberg, Yuki M.F. Andersen, Gunnar H. Gislason, Lone Skov, Jacob P. Thyssen
Adult atopic dermatitis (AD) is associated with overweight, obesity and cardiovascular diseases (CVD) in Americans, similarly to psoriasis, but no increased risk of CVD has been shown in European patients with AD. This study investigated the prevalence and risk of gallstones in adults with AD and in those with psoriasis as a proxy for obesity using nationwide data for all Danish citizens ≥&# ...
Pages: 627-631
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CLINICAL REPORT
Vascular Patterns in Cutaneous Ulcerated Basal Cell Carcinoma: A Retrospective Blinded Study Including Dermoscopy
Nicola Arpaia, Angela Filoni, Domenico Bonamonte, Giuseppe Giudice, Margherita Fanelli, Michelangelo Vestita
The aim of this retrospective study was to determine the type and prevalence of vascular patterns in the ulcerated and non-ulcerated portions of histologically proven basal cell carcinomas (BCCs) and correlate them with other dermoscopic and clinical features, including the clinically supposed diagnosis. Three authors retrospectively collected 156 clinical and 156 dermoscopic digital images of ulc ...
Pages: 612-616
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All articles

SPECIAL REPORT
Health-related Quality of Life in Children and Adolescents with Psoriasis: A Systematic Review and Meta-analysis
Hilde Randa, Tanja Todberg, Lone Skov, Lotte S. Larsen, Robert Zachariae
Studies demonstrating the negative impact of paediatric psoriasis on health-related quality of life (HRQOL) are accumulating, but little is known about moderators of HRQOL. The objectives of this review were to summarize studies on HRQOL in paediatric psoriasis and to explore the potential moderating influences of demographic and clinical variables. Searches were conducted by 2 independent researc ...
Pages: 555-563
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INVESTIGATIVE REPORT
Opioid Receptors in Psoriatic Skin: Relationship with Itch
Piotr Kupczyk, Adam Reich, Marcin Hołysz, Mariusz Gajda, Edyta Wysokińska, Anna Kobuszewska, Dmitry Nevozhay, Beata Nowakowska, Leon Strzadała, Paweł Poitr Jagodziński, Jacek C. Szepietowski
Psoriasis is an inflammatory immunogenetic skin disease, often accompanied by itch. Opioid receptors are known regulators of itch sensation in the central nervous system. In the brain, μ-opioid receptors may potentiate itch, while activation of κ-opioid receptors may reduce or even alleviate itch; however, the role of opioid receptors in itch perception in the skin is poorly understood. ...
Pages: 564-570
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice
Nazgol-Sadat Haddadi, Arash Foroutan, Sattar Ostadhadi, Ehsan Azimi, Nastaran Rahimi, Mehdi Nateghpour, Ethan A. Lerner, Ahmad Reza Dehpour
Intradermal administration of chloroquine (CQ) provokes scratching behavior in mice. Chloroquine-induced itch is histamine-independent and we have reported that the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway is involved in CQ-induced scratching behavior in mice. Previous studies have demonstrated that activation of N-methyl-d-aspartate receptors (NMDARs) induces NO production. ...
Pages: 571-577
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INVESTIGATIVE REPORT
Pre-elafin is Involved in Ultraviolet-induced Keratinocyte Apoptosis via Pro-caspase-3 Activation Associated with Cystatin-A Down­regulation
Hyangmi Kim, Minsoo Noh, Ok-Nam Bae, Chang-Hoon Lee, Ai-Young Lee
Pre-elafin controls keratinocyte integrity via cornified envelope formation and inhibition of desquamation, but its role in ultraviolet (UV)-induced keratinocyte apoptosis is unknown. This study examined the role of pre-elafin in volunteer skin samples and primary cultured normal human keratinocytes irradiated with phototoxic doses of UVA/narrow-band UVB, and in keratinocytes with pre-elafin overe ...
Pages: 578-585
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INVESTIGATIVE REPORT
Placental Growth Factor and Vascular Endothelial Growth Factor Together Regulate Tumour Progression via Increased Vasculature in Cutaneous T-cell Lymphoma
Tomomitsu Miyagaki, Makoto Sugaya, Tomonori Oka, Naomi Takahashi, Makiko Kawaguchi , Hiraku Suga, Hideki Fujita, Ayumi Yoshizaki, Yoshihide Asano, Shinichi Sato
Angiogenesis is regarded as an essential step in supporting tumour growth and metastasis. In haematological malignancies, including cutaneous T-cell lymphoma (CTCL), angiogenesis is increased and serum levels of some pro-angiogenic markers are elevated. The aim of this study was to investigate expression levels of placental growth factor (PlGF) and vascular endothelial growth factor (VEGF)-A in le ...
Pages: 586-592
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INVESTIGATIVE REPORT
Dermal CD271+ Cells are Closely Associated with Regeneration of the Dermis in the Wound Healing Process
Yohei Iwata, Yuichi Hasebe, Seiji Hasegawa, Satoru Nakata, Akiko Yagami, Kayoko Matsunaga, Kazumitsu Sugiura, Hirohiko Akamatsu
Stem cells have recently been shown to play important roles in wound healing. The aim of this study was to investigate the role of dermal CD271+ cells in wound healing. Full-thickness wounds were produced on the backs of 5-year-old and 24-week-old mice, and time-course of wound closure, CD271+ cell counts, and gene expression levels were compared. Delayed wound healing was observed in 24-week-old ...
Pages: 593-600
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INVESTIGATIVE REPORT
ItchApp©: An App-based eDiary for Assessment of Chronic Pruritus in Clinical Trials
Marvin Gernart, Athanasios Tsianakas, Claudia Zeidler, Claudia Riepe, Nani Osada, David Pihan, Sonja Ständer
Performing a reliable assessment of chronic pruritus remains a challenge. Electronic diaries are often used, but many of the scales have not been validated. ItchApp© was developed for Android smartphones in order to address this lack. A total of 40 subjects with chronic pruritus completed questionnaires both on paper and with ItchApp© (verbal rating scale, numerical rating scale, dynamic pruritu ...
Pages: 601-606
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INVESTIGATIVE REPORT
Mortality and Cause of Death in Patients with Pemphigus
Khalaf Kridin, Shira Zelber Sagi, Reuven Bergman
All-cause and cause-specific mortality among patients with pemphigus compared with the general population is yet to be established. This study investigated overall mortality and cause-specific mortality in a large immunopathologically validated cohort of patients with pemphigus. Mortality of patients with pemphigus was compared with age- and gender-matched control subjects in the general populatio ...
Pages: 607-611
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CLINICAL REPORT
Vascular Patterns in Cutaneous Ulcerated Basal Cell Carcinoma: A Retrospective Blinded Study Including Dermoscopy
Nicola Arpaia, Angela Filoni, Domenico Bonamonte, Giuseppe Giudice, Margherita Fanelli, Michelangelo Vestita
The aim of this retrospective study was to determine the type and prevalence of vascular patterns in the ulcerated and non-ulcerated portions of histologically proven basal cell carcinomas (BCCs) and correlate them with other dermoscopic and clinical features, including the clinically supposed diagnosis. Three authors retrospectively collected 156 clinical and 156 dermoscopic digital images of ulc ...
Pages: 612-616
Abstract  HTML  PDF
CLINICAL REPORT
Pretreatment with 5-Fluorouracil Cream Enhances the Efficacy of Daylight-mediated Photodynamic Therapy for Actinic Keratosis
Christoffer V. Nissen, Ida Marie Heerfordt, Stine R. Wiegell, Carsten S. Mikkelsen, Hans Christian Wulf
The efficacy of photodynamic therapy (PDT) with methyl aminolevulinate is reduced when treating actinic keratosis (AK) on the extremities in comparison with the face and scalp. Studies indicate that PDT efficacy can be improved by combining PDT with other treatment modalities. This randomized intra-individual study investigated whether pretreatment with topical 5% 5-fluorouracil (5-FU) enhanced th ...
Pages: 617-621
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CLINICAL REPORT
Diagnostic Value of Linear Fluorescence Along the Basement Membrane of Sweat Gland Ducts in Bullous Pemphigoid
Işın Sinem Bağcı, Orsolya N. Horváth, Enno Schmidt, Thomas Ruzicka, Miklós Sárdy
Linear IgG deposits along the basement membrane of adnexa has been proposed to be useful in the diagnosis of bullous pemphigoid (BP), but no controlled studies have been performed. This study evaluated linear IgG fluorescence of the basement membrane of sweat gland ducts (SGD) and other adnexa in perilesional biopsies from patients with BP (n = 64) and controls (n = 82), us ...
Pages: 622-626
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CLINICAL REPORT
Gallstone Risk in Adult Patients with Atopic Dermatitis and Psoriasis: Possible Effect of Overweight and Obesity
Alexander Egeberg, Yuki M.F. Andersen, Gunnar H. Gislason, Lone Skov, Jacob P. Thyssen
Adult atopic dermatitis (AD) is associated with overweight, obesity and cardiovascular diseases (CVD) in Americans, similarly to psoriasis, but no increased risk of CVD has been shown in European patients with AD. This study investigated the prevalence and risk of gallstones in adults with AD and in those with psoriasis as a proxy for obesity using nationwide data for all Danish citizens ≥&# ...
Pages: 627-631
Abstract  HTML  PDF
CLINICAL REPORT
Socioeconomic Inequalities and Severity of Plaque Psoriasis at a First Consultation in Dermatology Centers
Emmanuel Mahé, Alain Beauchet, Ziad Reguiai, François Maccari, Mireille Ruer-Mulard, Guillaume Chaby, Thierry Le Guyadec, Eric Estève, Catherine Goujon-Henry, Josiane Parier, Hugues Barthelemy, Edouard Bégon , Henri-Georges Steiner, Nathalie Bénéton, Thierry Boyé, Laure Mery-Bossard, Jean-Luc Schmutz, Pierre Bravard, Michèle-Léa Sigal and the GEM RESOPSO
Psoriasis has major physical, psychological, and social impacts: its management should not be restricted by individual financial considerations in Western countries as these have well-structured health systems and social/insurance coverage. We investigated if the socioeconomic characteristics of patients were associated with severity of psoriasis and access to healthcare. In a cross-sectional stud ...
Pages: 632-638
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SHORT COMMUNICATION
Efficacy of Body Lotion Containing N-palmitoylethanolamine in Subjects with Chronic Pruritus due to Dry Skin: A Dermatocosmetic Study
Katharina Visse , Christine Blome, Ngoc Quan Phan, Matthias Augustin, Sonja Ständer
Abstract is missing (Short Communication)
Pages: 639-641
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SHORT COMMUNICATION
Increased Serum Levels of Th2-type Cytokines and Eotaxin in Fibrillar-type Dermatitis Herpetiformis
Teruhiko Makino, Yoko Yoshihisa, Megumi Mizawa, Kiyohiro Tsutsui, Chihiro Nishijima, Makoto Inaoki, Tadamichi Shimizu
Abstract is missing (Short communication)
Pages: 642-643
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SHORT COMMUNICATION
Expression of Antimicrobial Peptides in Nail Psoriasis and Normal Nails
Ieva Saulite, Mara Pilmane, Janis Kisis
Abstract is missing (Short communication)
Pages: 644-645
Abstract  HTML  PDF
SHORT COMMUNICATION
Monitoring Ingenol Mebutate Gel Treatment of Actinic Keratoses by Reflectance Confocal Microscopy
Jose Luis López Estebaranz, Ana Pampín Franco, Reyes Gamo Villegas, Uxúa Floristán
Abstract is missing (Short communication)
Pages: 646-648
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SHORT COMMUNICATION
Ambulatory Photodynamic Therapy for Superficial Basal Cell Carcinoma: An Effective Light Source?
Janneke P.H.M. Kessels, Nedim Dzino, Patty J. Nelemans, Klara Mosterd, Nicole W.J. Kelleners-Smeets
Abstract is missing (Short communication)
Pages: 649-650
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SHORT COMMUNICATION
Telangiectatic Mycosis Fungoides: A New Clinicopathological Presentation Mimicking Acquired Naevoid Telangiectasia
Lidia García-Colmenero, Laia Curto-Barredo, Ignacio Gómez-Martin, Fernando Gallardo, Ramon M. Pujol
Abstract is missing (Short communication)
Pages: 651-652
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SHORT COMMUNICATION
Increased Incidence of Cutaneous Vasculitic Ulcers: 30-year Results from a Population-based Retrospective Study
Teija Kimpimäki, Riitta Huotari-Orava, Jaakko Antonen, Annikki Vaalasti
Abstract is missing (Short communication)
Pages: 653-654
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SHORT COMMUNICATION
Lupus Miliaris Disseminatus Faciei: Not Only a Facial Dermatosis
Marthe-Lisa Schaarschmidt, Michèle Schlich, Janina Staub, Astrid Schmieder, Sergij Goerdt, Wiebke K. Peitsch
Abstract is missing (Short communication)
Pages: 655-656
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SHORT COMMUNICATION
Homozygous Nonsense Mutation and Additional Deletion of an Amino Acid in BPAG1e Causing Mild Localized Epidermolysis Bullosa Simplex
Yinghong He, Juna Leppert, Holger Steinke, Cristina Has
Abstract is missing (Short communication)
Pages: 657-659
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SHORT COMMUNICATION
Borrelia-associated Fasciitis: Two Cases
Caroline Lang, Isabelle Masouyé, Michael Mühlstädt, Sandrine Quenan, Gürkan Kaya, Emmanuel Laffitte
Abstract is missing (Short communication)
Pages: 660-662
Abstract  PDF
SHORT COMMUNICATION
Cost-effectiveness in Psychodermatology: A Case Series
Jonathan M.R. Goulding , Natasha Harper, Liam Kennedy, Kate R. Martin
Abstract is missing (Short communication)
Pages: 663-664
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SHORT COMMUNICATION
Cutaneous Gamma-delta T-cell Lymphoma with an Initially Indolent Course Mimicking Lupus Panniculitis
Johannes Benecke, Cyrill Géraud, Jan P. Nicolay
Abstract is missing (Short communication)
Pages: 665-666
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QUIZ
Sudden Onset of an Itchy Papular Eruption: A Quiz
Manuel P. Pereira, Dieter Metze, Sonja Ständer
Abstract is missing (Quiz)
Pages: 667-668
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QUIZ
Annular Erythematous Scaly Lesions on the Face: A Quiz
Jiu-Hong Li, Xiao-Yi Yang , Jie Cao , Xiao-Lu Wang , Hao Guo, Abdulrahman A.A. Amer
Abstract is missing (Quiz)
Pages: 669-670
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QUIZ
Symmetrical Keratotic Papules on the Hands: A Quiz
Magdalena Zychowska, Aleksandra Batycka-Baran, Zdzisław Woźniak, Anita Hryncewicz-Gwóźdź, Wojciech Baran
Abstract is missing (Quiz)
Pages: 671-672
Abstract  HTML  PDF