Content

Content - Volume 101, January

Editor's choice in this issue

CLINICAL REPORT
Response to Biologics During the First Six Months of Therapy in Biologic-naïve Patients with Psoriasis Predicts Risk of Disease Flares: A Danish Nationwide Study
Nikolai Loft, Alexander Egeberg, Mads Kirchheiner Rasmussen, Lars Erik Bryld, Christoffer V. Nissen, Tomas Norman Dam, Kawa Khaled Ajgeiy, Lars Iversen, Lone Skov
We performed this study as treatment of psoriasis with biologics is often based on short-term response criteria, but patients are often treated long-term, and knowledge about long-term outcome of these response criteria is limited. We found that response early in the treatment predicted risk of drug discontinuation and risk of disease flares, i.e. a low PASI in the first six months is associated with lower risk of disease discontinuation and flares. We feel this paper is important as it provides evidence for guidelines in treatment of psoriasis with biologics.
Pages: 1-7
Abstract  HTML  PDF

All articles

SPECIAL REPORT
NEWSLETTER (January 2021)
Pages: 1-2
Abstract  PDF
QUIZ
Concentric Skin Rings, Fever and Arthritis: A Quiz
Martina Yaneva, Zdravka Demerdjieva, Miroslava Kadurina, Razvigor Darlenski
Abstract is missing (Quiz)
Pages: 1-2
Abstract  HTML  PDF
SHORT COMMUNICATION
High Expression of Lactate Dehydrogenase A is a Potential Promoter of Malignant Behaviour in Extramammary Paget’s Disease
Kohei Ogawa, Keiji Shimada, Toshihiro Takai, Yasuhiro Mitsui, Masamitsu Kuwahara, Hideo Asada
Abstract is missing (Short communication)
Pages: 1-2
Abstract  HTML  PDF
CORRESPONDENCE
Geosocial Dating Applications Mirror the Increase in Sexually Transmitted Diseases
Kasper Køhler Alsing, Tobias Steen Sejersen, Gregor B.E. Jemec
Abstract is missing (Correspondence)
Pages: 1-2
Abstract  HTML  PDF
REVIEW
Bullous Pemphigoid Associated with Anti-programmed Cell Death Protein 1 and Anti-programmed Cell Death Ligand 1 Therapy: A Review of the Literature
Aikaterini Tsiogka, Johann W. Bauer, Aikaterini Patsatsi
Bullous pemphigoid constitutes a rare dermatological immune-related adverse event of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors. Herein, we review all published cases of anti-PD-1/PD-L1 related bullous pemphigoid and discuss current knowledge on this condition. Clinical and diagnostic findings were found to resemble those of classic bullous pemphigoid. ...
Pages: 1-7
Abstract  HTML  PDF
CLINICAL REPORT
Risk of Hidradenitis Suppurativa Comorbidities Over Time: A Prospective Cohort Study of Danish Blood Donors
Rune Kjærsgaard Andersen, Isabella Charlotte Loft, Kristoffer Burgdorf, Christian Erikstrup, Ole B. Pedersen, Gregor B.E. Jemec
Hidradenitis suppurativa is a common recurrent inflammatory skin disease. It is associated with multiple comorbidities whose temporal relationships are unknown due to long diagnostic delays. This study of otherwise healthy blood donors with self-reported symptoms of hidradenitis suppurativa investigated the temporal relationships of comorbidities. A prospective survival analysis on a nationwide co ...
Pages: 1-6
Abstract  HTML  PDF
SHORT COMMUNICATION
Dermal Periostin: A New Player in Itch of Prurigo Nodularis
Takashi Hashimoto, Leigh A. Nattkemper, Hei Sung Kim, Christina D. Kursewicz, Emilie Fowler, Serena M. Shah, Sonali Nanda, Rachel A. Fayne, Paolo Romanelli, Gil Yosipovitch
Abstract is missing (Short communication)
Pages: 1-2
Abstract  HTML  PDF
CLINICAL REPORT
Alteration in the Skin Microbiome in Cutaneous Graft Versus Host Disease
Ying Gu, Jing Sun, Kun Li, Xia Wu, Jianzhong Zhang
Graft versus host disease (GVHD) is a common complication of haematopoietic stem cell transplantation. This study examined the cutaneous microbiome in relation to the pathogenesis of cutaneous GVHD. Bacterial swabs were taken from several sites on 12 patients with cutaneous GVHD. Microbiotas were characterized by sequencing 16S rRNA bacterial genes on the MiSeq platform. Microbiome diversity in pa ...
Pages: 1-7
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Proposal for Cut-off Scores for Sensitive Skin on Sensitive Scale-10 in a Group of Adult Women
Cécile Legeas, Laurent Misery, Joachim W. Fluhr, Alain-Claude Roudot, Anne-Sophie Ficheux, Emilie Brenaut
Sensitive skin is commonly assessed on the basis of self-reports from patients, and sometimes questionnaires, such as the Sensitive Scale-10, are used. The severity of sensitive skin follows a continuum, from the absence of sensitive skin to very sensitive skin. The aims of this cross-sectional study were to compare subjects with and without symptomatic sensitive skin and to propose diagnostic cri ...
Pages: 1-6
Abstract  HTML  PDF
SHORT COMMUNICATION
Association of Development of Solar Elastosis with Increased Expression of Fibrillin-1, LTBP-2 and Fibulin-4 in Combination with Decreased Expression of LTBP-4
Teruhiko Makino, Ko Kagoyama, Chisato Murabe, Tomoyuki Nakamura, Tadamichi Shimizu
Abstract is missing (Short communication)
Pages: 1-2
Abstract  HTML  PDF
QUIZ
A Woman with Gradually Enlarging Brownish Confluent Papules on the Left Thigh: A Quiz
Arcadi Altemir, Elena Canal-Garcia, Ramon M. Pujol
Abstract is missing (Quiz)
Pages: 1-2
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Nocebo Effects on Cowhage-evoked Itch: A Randomized Controlled Trial of Classical Conditioning and Observational Learning
Joseph S. Blythe, Kaya J. Peerdeman, Dieuwke S. Veldhuijzen, Myrthe M.E. van Schothorst, Mia A. Thomaïdou, Antoinette I.M. van Laarhoven, Andrea W.M. Evers
To investigate learning processes underlying nocebo effects on itch, this study measured the efficacy of classical conditioning and observational learning for inducing nocebo effects on cowhage-evoked itch and scratching behaviour. A total of 58 healthy female participants were assigned to classical conditioning, observational learning, or sham conditioning groups. In the classical conditioning gr ...
Pages: 1-6
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Tumour Necrosis Factor Alpha-induced Protein 3 Negatively Regulates Cutibacterium acnes-induced Innate Immune Events in Epidermal Keratinocytes
Lilla Erdei, Beáta Szilvia Bolla, Renáta Bozó, Gábor Tax, Edit Urbán, Katalin Burián, Lajos Kemény, Kornélia Szabó
Human epidermal keratinocytes sense the presence of human skin microbiota through pathogen recognition receptors, such as toll-like receptors, and induce innate immune and inflammatory events. In healthy epidermis there is an absence of inflammation despite the continuous presence of cutaneous microbes, which is evidence of an effective immune regulatory mechanism. The aim of this study was to inv ...
Pages: 1-10
Abstract  HTML  PDF
SHORT COMMUNICATION
Are Infants and Toddlers with Moderate-to-severe Atopic Dermatitis Undertreated? Experiences of a Finnish Tertiary Care Hospital
Andreas Antti, Alexander Salava, Miia Perälä, Anna S. Pelkonen, Mika J. Mäkelä, Anita Remitz
Abstract is missing (Short communication)
Pages: 1-3
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Deficiency of Cathelicidin-related Antimicrobial Peptide Promotes Skin Papillomatosis in Mus musculus Papillomavirus 1-infected Mice
Sonja Dorfer, Katharina Strasser, Siegfried Reipert, Michael B. Fischer, Saeed Shafti-Keramat, Michael Bonelli, Georg Schröckenfuchs, Wolfgang Bauer, Stefanie Kancz, Lena Müller, Alessandra Handisurya
Cathelicidins have been reported to inhibit human papillomavirus infection in vitro; however, nothing is known about their activity in vivo. In this study, experimental skin infection with Mus musculus papillomavirus 1 resulted in robust development of cutaneous papillomas in cyclosporine A-treated C57BL/6J mice deficient for the murine cathelicidin-related antimicrobial peptide (CRAMP), in contra ...
Pages: 1-7
Abstract  HTML  PDF
SHORT COMMUNICATION
Cutaneous Hyperaesthesia in SARS-CoV-2 Infection: Rare but not Unique Clinical Manifestation
Piotr K. Krajewski, Joanna Maj, Jacek C. Szepietowski
Abstract is missing (Short communication)
Pages: 1-2
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Methotrexate Use for Patients with Psoriasis and Risk of Cutaneous Squamous Cell Carcinoma: A Nested Case-control Study
Filippos Giannopoulos, Martin Gillstedt, Marta Laskowski, Kasper Bruun Kristensen, Sam Polesie
An association between methotrexate use and risk of cutaneous squamous cell carcinoma has been reported in patients with rheumatoid and psoriatic arthritis. A nested case-control study was performed to investigate if methotrexate use among patients with psoriasis was associated with increased risk of cutaneous squamous cell carcinoma. Data were obtained from Swedish registers and included 623 pati ...
Pages: 1-6
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Pain in Hidradenitis Suppurativa: A Cross-sectional Study of 1,795 Patients
Piotr K. Krajewski, Łukasz Matusiak, Esther von Stebut, Michael Schultheis, Uwe Kirschner, Georgios Nikolakis, Jacek C. Szepietowski
Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects the pilosebaceous unit of the intertriginous body areas. Pain is one of the most important problems in patients with hidradenitis suppurativa. The aim of this study, which included 1,795 patients, was to evaluate the prevalence and characteristics of pain. The intensity of pain was assessed with a numerical rating scale ...
Pages: 1-4
Abstract  HTML  PDF
CLINICAL REPORT
Malignant Eccrine Porocarcinoma in Finland During 2007 to 2017
Anna-Stiina Meriläinen, Eero Pukkala, Tom Böhling, Virve Koljonen
Malignant eccrine porocarcinoma is a rare skin adnexal cancer arising from the sweat glands. Little is known about the epidemiology and incidence of eccrine porocarcinoma. This registry-based study examined the epidemiology and incidence data for eccrine porocarcinoma from the Finnish Cancer Registry. The study included all persons diagnosed with eccrine porocarcinoma in 2007 to 2017. There were 6 ...
Pages: 1-4
Abstract  HTML  PDF
SHORT COMMUNICATION
Avapritinib for Cutaneous Mastocytosis
Hannah Lee, Tian Li, Joshua Wisell, Jeffrey Schowinsky, William A. Robinson
Abstract is missing (Short communication)
Pages: 1-2
Abstract  HTML  PDF
QUIZ
Enlarging Alopecic Plaque on the Scalp: A Quiz
Yujie Wen, Shuxia Yang, Yang Wang
Abstract is missing (Quiz)
Pages: 1-2
Abstract  HTML  PDF
CORRESPONDENCE
How to Triple Pocket Dermatoscopy Device Magnification and Avoid Digital Interpolation
Calogero Pagliarello, Carlo Renè Girardelli
Abstract is missing (Correspondence)
Pages: 1-1
Abstract  HTML  PDF
SHORT COMMUNICATION
Are the Recommended Excision Margins for Basal Cell Carcinoma Too Defensive? A Retrospective Chart Study and Evaluation of the Dutch Guideline
Eva van Loo, Patty J. Nelemans, Corine Peters, Myrurgia Abdul-Hamid, Nicole W.J. Kelleners-Smeets
Abstract is missing (Short communication)
Pages: 1-3
Abstract  HTML  PDF
CLINICAL REPORT
Systematic Literature Review and Network Meta-analysis of the Efficacy and Acceptability of Interventions in Actinic Keratoses
Khaled Ezzedine, Caroline Painchault, Melanie Brignone
A systematic literature review was conducted to identify and qualitatively assess randomized controlled trials in immunocompetent patients ≥ 18 years with head- region lesions of actinic keratoses who were treated with field-directed, lesion-directed and other therapies. Network meta-analysis was used to quantitatively evaluate field-directed therapies (5-fluorouracil formulations, diclofenac ...
Pages: 1-8
Abstract  HTML  PDF
CLINICAL REPORT
Response to Biologics During the First Six Months of Therapy in Biologic-naïve Patients with Psoriasis Predicts Risk of Disease Flares: A Danish Nationwide Study
Nikolai Loft, Alexander Egeberg, Mads Kirchheiner Rasmussen, Lars Erik Bryld, Christoffer V. Nissen, Tomas Norman Dam, Kawa Khaled Ajgeiy, Lars Iversen, Lone Skov
Early response to treatment with biologics might be important for the stability of psoriasis and long-term outcome. The aim of this study was therefore to assess whether risk of flares and drug survival are associated with disease activity in the first 6 months of treatment of psoriasis with biologics. Biologic-naïve patients from the Danish nationwide registry, DERMBIO, were grouped based on abs ...
Pages: 1-7
Abstract  HTML  PDF
CLINICAL REPORT
Sex-associated Risk Factors for Co-infection with Chlamydia trachomatis and Neisseria gonorrhoea among Patients Presenting to a Sexually Transmitted Infection Clinic
Farnam Barati Sedeh, Simon F. Thomsen, Helle K. Larsen, Henrik Westh, Kirsten Salado-Rasmussen
The aim of this study was to investigate the characteristics of patients co-infected with Chlamydia trachomatis and Neisseria gonorrhoea. A retrospective case-control study was performed, which included 399 co-infected patients seen at a sexually transmitted infection clinic in Copenhagen, Denmark. Case-control groups included 300 patients who tested positive only for N. gonorrhoea, 300 who tested ...
Pages: 1-7
Abstract  HTML  PDF
CLINICAL REPORT
Repetitive Daylight Photodynamic Therapy versus Cryosurgery for Prevention of Actinic Keratoses in Photodamaged Facial Skin: A Prospective, Randomized Controlled Multicentre Two-armed Study
Sigrid Karrer, Rolf-Markus Szeimies, Wolfgang G. Philipp-Dormston, Peter A. Gerber, Welf Prager, Elisabeth Datz, Florian Zeman, Karolina Müller, Michael Koller
Actinic keratoses are a chronic condition in ultraviolet-damaged skin, with a risk of progressing to invasive skin cancer. The aim of this study was to investigate the preventive potential of field-directed repetitive daylight photodynamic therapy for actinic keratoses. A randomized trial was performed, including 58 patients with ≥5 actinic keratoses on photodamaged facial skin, who received eit ...
Pages: 1-9
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Effect of Sex in Systemic Psoriasis Therapy: Differences in Prescription, Effectiveness and Safety in the BIOBADADERM Prospective Cohort
Carlos Pelayo Hernández-Fernández, Gregorio Carretero, Raquel Rivera, Carlos Ferrándiz, Esteban Daudén, Pablo de la Cueva, Isabel Belinchón, Francisco Javier Gómez-García, Enrique Herrera-Acosta, Diana P. Ruiz-Genao, Marta Ferrán, Mercé Alsina, Ofelia Baniandrés-Rodríguez, José Luis Sánchez-Carazo, Rafael Botella-Estrada, Antonio Sahuquillo-Torralba, Lourdes Rodríguez, Jaime Vilar-Alejo, Carmen García-Donoso, José M. Carrascosa, Mar Llamas-Velasco, Enrique Herrera-Ceballos, Jose Luis López-Estebaranz, Conrad Pujol-Marco, Miguel Angel Descalzo, Ignacio Garcia-Doval, and the BIOBADADERM Study Group
The effect of sex on systemic therapy for psoriasis has not been well studied. The aim of this study was to analyse a large multicentre Spanish cohort of 2,881 patients with psoriasis (58.3% males), followed from January 2008 to November 2018, to determine whether sex influences prescription, effectiveness of therapy, and the risk of adverse events. The results show that women are more likely than ...
Pages: 1-8
Abstract  HTML  PDF
CLINICAL REPORT
Characterization of Basosquamous Cell Carcinoma: A Distinct Type of Keratinizing Tumour
Giulio Gualdi, Simone Soglia, Marta Fusano, Paola Monari, Federica Giuliani, Annamaria Porreca, Marta Di Nicola, Piergiacomo Calzavara-Pinton, Paolo Amerio
Basosquamous carcinoma is a rare clinical entity, which comprises 1.7–2.7% of all skin carcinomas. It is described as a basal cell carcinoma with features of squamous differentiation. To date, studies of the epidemiology of basosquamous carcinoma have been few and small in size. We report here the most extensive series of basosquamous carcinomas published to date, highlighting the differences be ...
Pages: 1-5
Abstract  HTML  PDF
SHORT COMMUNICATION
Hypohidrotic Ectodermal Dysplasia with c.28delG Mutation in Ectodysplasin A Gene and Severe Atopic Dermatitis Treated Successfully with Tofacitinib
Xiangqian Li, Xia Wu, Dirk M. Elston, Jianzhong Zhang, Cheng Zhou
Abstract is missing (Short communication)
Pages: 1-2
Abstract  HTML  PDF