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Content - Volume 101, May

Editor's choice in this issue

INVESTIGATIVE REPORT
Differentiating Arteriolosclerotic Ulcers of Martorell from Other Types of Leg Ulcers Based on Vascular Histomorphology
Julia Deinsberger, Jonas Brugger, Philipp Tschandl, Barbara Meier-Schiesser, Florian Anzengruber, Simon Bossart, Stanislava Tzaneva, Peter Petzelbauer, Kornelia Böhler, Helmut Beltraminelli, Jürg Hafner, Benedikt Weber
We performed this study because the differential diagnosis of the arteriolosclerotic ulcer of Martorell is challenging, due to a lack of clearly affirmative instrument based diagnostic criteria. Our main goal was to provide quantitative histomorphological information on arteriolar wall changes in patients suffering from an arteriolosclerotic ulcer of Martorell, in comparison with ulcerative or non-ulcerative controls. This information may facilitate the histological diagnosis, differentiating Martorell ulcers from other types of leg ulcers, and may also contribute to a better understanding of the aetiopathogenesis of this disease.
Pages: 1-8
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SPECIAL REPORT
NEWSLETTER (May 2021)
Pages: 1-2
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SHORT COMMUNICATION
French Teledermatologists: Activity and Motivations Prior to the COVID-19 Pandemic
Mathieu Bataille, Emmanuel Mahé, Valérie Dorizy-Vuong, Charbel Skayem, Anne Dompmartin, Marie-Aleth Richard, Jean Friedel, Florence Ottavy, Marie-Sophie Gautier, Priscille Carvalho, Tu Anh Duong on behalf of the Groupe de Télé-Dermatologie & e-Santé de la Société Française de Dermatologie (TELDES)
Abstract is missing (Short communication)
Pages: 1-2
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CLINICAL REPORT
Microbiome Profile in Patients with Adult Balanoposthitis: Relationship with Redundant Prepuce, Genital Mucosa Physical Barrier Status and Inflammation
Meng Li, Jian-Xun Mao, Hang-Hang Jiang, Chun-Ming Huang, Xing-Hua Gao, Li Zhang
Balanoposthitis is a common inflammatory condition of male genitalia, while the overall microbiota spectrum and its relevance to contributing factors have yet to be determined. This case-control study included patients with balanoposthitis (n = 26) and matched healthy controls (n = 29), both uncircumcised. Overt fungal infection in balanoposthitis was excluded, swab samples were collected, ...
Pages: 1-6
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SHORT COMMUNICATION
Topical Zinc Oxide Assessed in Two Human Wound-healing Models
Magnus S. Ågren, Natthawut Phothong, Ewa A. Burian, Mette Mogensen, Merete Hædersdal, Lars N. Jorgensen
Abstract is missing (Short communication)
Pages: 1-2
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QUIZ
Round Granulomatous Lesions in a Young Girl: A Quiz
Fuh-Miin Liang, Xiaobo Feng, Li Li, Qiangqiang Zhang, Junhao Zhu, Mei Zeng, Ferry Hagen, Liping Zhu, Min Zhu
Abstract is missing (Quiz)
Pages: 1-3
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CLINICAL REPORT
Evaluation of a One-step Dose Reduction Strategy of Adalimumab, Etanercept and Ustekinumab in Patients with Psoriasis in Daily Practice
Selma Atalay, Lara S. van der Schoot, Laura Vandermaesen, Lieke J. van Vugt, Mascha Eilander, Juul M.P.A. van den Reek, Elke M.G.J. de Jong
Dose reduction of biologics for psoriasis could contribute to lower drug exposure. This study evaluated a one-step, tightly controlled, biologic dose reduction strategy in a prospective daily practice cohort. In patients with psoriasis with low disease activity using adalimumab, etanercept or ustekinumab for at least 6 months, the dosing interval was prolonged with 33%. Patients could return to th ...
Pages: 1-7
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CLINICAL REPORT
Evaluation of Psoriasis Area and Severity Index as a Proxy for Bio­markers of Systemic Disease under Treatment with Tumour Necrosis Factor-alpha and Interleukin 12/23 Antagonists in Patients with Psoriasis: A Retrospective Cohort Study of 186 Treatment Cycles
Jochen H.O. Hoffmann, Christian Knoop, Knut Schäkel, Alexander H. Enk, Eva N. Hadaschik
The efficacy of psoriasis treatments is usually evaluated using the Psoriasis Area and Severity Index (PASI). However, there is a lack of systematic statistical assessments of PASI as a proxy for systemic disease in individual patients. Therefore, a retrospective study of 186 treat­ments with adalimumab, etanercept, and ustekinumab for psoriasis (341 patient-years) was performed. While PASI signi ...
Pages: 1-7
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SHORT COMMUNICATION
Establishment of a Nationwide Patient Database for Clinical Trial Recruitment in Dermatology: Concept and Patient Characteristics
Dorra Bouazzi, Anette Bygum, Lone Skov, Mikkel Lindskov Sachs, Lars Iversen, Merete Hædersdal, Gregor B.E. Jemec, Simon F. Thomsen
Abstract is missing (Short communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Diagnostic Value of Genotypic Analysis in Primary Cutaneous Lymphomas using Standardized BIOMED-2 Polymerase Chain Reaction Protocols: Experience in Daily Clinical Practice
Daniel López Aventín, Fernando Gallardo, Luis Colomo, Ester Moragón, María Carmen Vela, Xavier Duran Jordà, Beatriz Bellosillo, Ramon M. Pujol
BIOMED-2 Concerted Action BMH4-CT98-3936 (BIOMED-2) PCR protocols are an important diagnostic tool in the evaluation of cutaneous lymphomas. The aim of this study was to assess the diagnostic value of the genotyping results obtained by these techniques in daily clinical practice. A total of 360 paraffin-embedded skin samples were retrospectively reviewed from 114 cutaneous T-cell lymphomas and 35 ...
Pages: 1-7
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INVESTIGATIVE REPORT
Internal Migration and Leprosy in Shanghai from 2000 to 2019: an Epidemiological Study of New Cases
Jianyu Zhu, Chao Shi, Degang Yang, Yeqiang Liu, Jia Chen, Meiping Ye, Chunjie Liao, Zhichun Jing, Pingyu Zhou
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Massive internal migration from rural to urban areas poses new challenges for leprosy control in Shanghai, China. This retrospective epidemiological study examined new cases of leprosy diagnosed in Shanghai from 2000 to 2019, with emphasis on internal migration cases. There were 145 cases of leprosy in the study period; the ma ...
Pages: 1-6
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INVESTIGATIVE REPORT
Investigation of Genetic Mutations in High-risk and Low-risk Basal Cell Carcinoma in a Non-Caucasian Population by Whole Exome Sequencing
Hyun Jee Kim, Minho Lee, Young Bok Lee, Dong Soo Yu
This study analysed genomic mutations in basal cell carcinoma using whole exome sequencing of DNA specimens obtained from 20 Korean patients. Histological evaluation determined that 15 (75%) were low-risk basal cell carcinomas, and 5 (25%) were high-risk basal cell carcinomas. Seventy-five percent of the basal cell carcinomas harboured somatic mutations in hedge­hog pathway genes (PTCH1, 40% and ...
Pages: 1-6
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SHORT COMMUNICATION
Diagnostic Challenge of Bilateral Martorell Hypertensive Ischaemic Leg Ulcers
Lea F. Kraus, Katrin Elsharkawi-Welt, Thorsten Peters, Sabine Kastler, Diana Crisan, Anna Lipke, Codruta Tncau, Elisabeth Lormes, Michael Mühlberger, Karin Scharffetter-Kochanek
Abstract is missing (Short communication)
Pages: 1-2
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REVIEW
Patient-reported Outcome Measures for Angioedema: A Literature Review
Anna Trier Heiberg Brix, Henrik Balle Boysen, Karsten Weller, Teresa Caballero, Anette Bygum
Angioedema and hereditary angioedema are characterized by swelling of the subcutaneous and/or submucosal tissue, resulting in localized oedema. The rarity, but also the diverse clinical presentation, of these conditions can be challenging regarding diagnosis, treatment, and management. Patient-reported outcome measures (PROMs) are data received directly from the patient, providing the patient’s ...
Pages: 1-5
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CLINICAL REPORT
Long-term Mortality among Patients with Chronic Ulcers
Jenni E. Salenius, Minna Suntila, Tiina Ahti, Heini Huhtala, Annikki Vaalasti, Teea T. Salmi, Teija Kimpimäki
Chronic ulcers cause a significant burden to patients and society. This study evaluated long-term mortality among patients with chronic ulcers diagnosed at a dermatology clinic between 1980 and 2010. The mortality risk and causes of death of 3,489 patients with ulcers were compared with a matched reference group of 10,399 individuals, and factors associated with increased mortality risk were exami ...
Pages: 1-6
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INVESTIGATIVE REPORT
Contact Allergy to Oxidized Linalool and Oxidized Limonene is Over-represented in Individuals with Photocontact Allergy to Ketoprofen
Magnus Bruze, Victoria Marmgren, Annarita Antelmi, Monica Hindsén Stenström, Cecilia Svedman, Erik Zimersson, Martin Mowitz
Simultaneous contact allergies are common in individuals with photocontact allergy to ketoprofen. The rate of contact allergy to the fragrance substances oxidized linalool and oxidized limonene in ketoprofen-photo­allergic individuals were investigated in comparison with the corresponding rates in individuals without photo­contact allergy to ketoprofen, using Fisher’s exact test. A total of 4, ...
Pages: 1-6
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CLINICAL REPORT
Psoriasis on the Leg: Site-specific Histopathological and Immuno­histochemical Features and Diagnostic Difficulties
Mihaela Fülle, Dieter Metze, Almut Böer-Auer, Nani Osada, Stephan A. Braun
The histopathology of psoriasis can lack classical features on certain anatomical sites. The aim of this study was to detail the histopathology and immunophenotype of psoriasis on the legs, in order to differentiate it from other inflammatory dermatoses, such as stasis dermatitis. The histopathology of psoriasis on the legs was retrospectively compared with psoriasis on the trunk and stasis dermat ...
Pages: 1-8
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SHORT COMMUNICATION
Lambert-Eaton Myasthenic Syndrome and Paraneoplastic Cerebellar Degeneration Associated with Merkel Cell Carcinoma with Unknown Primary: A Case Report
Andrea Agostini, Martina Merli, Gianluca Avallone, Lorenza Burzi, Luca Mastorino, Mattia Parisi, Davide Bertuzzo, Bruno Ferrero, Marzia Cerrato, Serena Badellino, Luca Molinaro, Leonardo Lopiano, Simone Ribero, Pietro Quaglino
Abstract is missing (Short communication)
Pages: 1-2
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SHORT COMMUNICATION
Lower Eyelid Nodule: Chalazion or Idiopathic Facial Aseptic Granuloma? A Case Series
Anais Zanella, Flora Dresco, François Aubin, Eve Puzenat
Abstract is missing (Short communication)
Pages: 1-2
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QUIZ
Steroid Refractory Figurate Eruption with Eosinophilia in a Young Adult Man: A Quiz
Gabriela Żuk, Dominik Samotij, Justyna M. Szczęch, Adam Reich
Abstract is missing (Quiz)
Pages: 1-3
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INVESTIGATIVE REPORT
Differentiating Arteriolosclerotic Ulcers of Martorell from Other Types of Leg Ulcers Based on Vascular Histomorphology
Julia Deinsberger, Jonas Brugger, Philipp Tschandl, Barbara Meier-Schiesser, Florian Anzengruber, Simon Bossart, Stanislava Tzaneva, Peter Petzelbauer, Kornelia Böhler, Helmut Beltraminelli, Jürg Hafner, Benedikt Weber
Clinical differential diagnosis of arteriolosclerotic ulcers of Martorell is challenging due to the lack of clearly affirmative instrument-based diagnostic criteria. The aim of this study was to develop vascular histomorphological diagnostic criteria differentiating Martorell ulcers from other types of leg ulcers. The histomorphology of patients diagnosed with arteriolosclerotic ulcers of Martorel ...
Pages: 1-8
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INVESTIGATIVE REPORT
DNA Copy Number Variation Associated with Anti-tumour Necrosis Factor Drug Response and Paradoxical Psoriasiform Reactions in Patients with Moderate-to-severe Psoriasis
Ancor Sanz-Garcia, Alejandra Reolid, Laura H. Fisas, Ester Muñoz-Aceituno, Mar Llamas-Velasco, Antonio Sahuquillo-Torralba, Rafael Botella-Estrada, Jorge García-Martínez, Raquel Navarro, Esteban Daudén, Francisco Abad-Santos, Maria C. Ovejero-Benito
Biological drugs targeting tumour necrosis factor are effective for psoriasis. However, 30–50% of patients do not respond to these drugs and may even develop paradoxical psoriasiform reactions. This study search­ed for DNA copy number variations that could predict anti-tumour necrotic factor drug response or the appearance of anti-tumour necrotic factor induced psoriasiform reactions. Periphera ...
Pages: 1-7
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