Content

Content - Volume 97, Issue 1

Editors choice in this issue

EDITORIAL
A New Look for ActaDV with More Rapid Publication
Anders Vahlquist, Artur Schmidtchen, Agneta Andersson
Abstract is missing (Editorial)
Page: 3
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INVESTIGATIVE REPORT
Inverse Association Between Atopy and Melanoma: A Case-control Study
Vivien Marasigan, Marie-Anne Morren, Julien Lambert, Karen Medaer, Steffen Fieuws, Tamar Nijsten, Marjan Garmyn
Heightened cutaneous immune surveillance in atopic patients may inhibit development of melanoma. The aim of this study was to analyse the association between atopy and melanoma (development and outcome). A total of 188 cases of melanoma and 596 healthy controls were interviewed by telephone with a standardized questionnaire on atopic, demographic and melanoma characteristics. Cases were matched wi ...
Pages: 54-57
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SHORT COMMUNICATION
Whole-Exome-Sequencing Reveals Small Deletions in CASP14 in Patients with Autosomal Recessive Inherited Ichthyosis
Peter Kirchmeier, Andreas Zimmer, Bakar Bouadjar, Bernd Rösler, Judith Fischer
Abstract is missing (Short communication)
Pages: 102-104
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All articles

EDITORIAL
A New Look for ActaDV with More Rapid Publication
Anders Vahlquist, Artur Schmidtchen, Agneta Andersson
Abstract is missing (Editorial)
Page: 3
Abstract  HTML  PDF
SPECIAL REPORT
Definition of Sensitive Skin: An Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch
Laurent Misery, Sonja Ständer, Jacek C. Szepietowski, Adam Reich, Joanna Wallengren, Andrea W.M. Evers, Kenji Takamori, Emilie Brenaut, Christelle Le Gall-Ianotto, Joachim Fluhr, Enzo Berardesca, Elke Weisshaar
Sensitive skin is a frequent complaint in the general population, in patients, and among subjects suffering from itch. The International Forum for the Study of Itch (IFSI) decided to initiate a special interest group (SIG) on sensitive skin. Using the Delphi method, sensitive skin was defined as “A syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus, an ...
Pages: 4-6
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SPECIAL REPORT
Acne and Nutrition: A Systematic Review
Friederike Fiedler, Gabriele I. Stangl, Eckhard Fiedler, Klaus-Michael Taube
Few well-defined, evidence-based nutritional recommendations for people with skin diseases have been published in the scientific literature and standard dermatological textbooks. Using a systematic review of acne vulgaris as an example, the aim of this study was to determine whether there are systematic studies on the topic and, if so, of what quality. Four evidence levels were defined: (A) double ...
Pages: 7-9
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INVESTIGATIVE REPORT
Transforming Growth Factor Beta Gene Signatures are Spatially Enriched in Keloid Tissue Biopsies and Ex vivo-Cultured Keloid Fibroblasts
Adam Taylor, David C. Budd, Barbara Shih, Oliver Seifert, Andrew Beaton, Tracey Wright, Maria Dempsey, Fiona Kelly, Julia Egerton, Richard P. Marshall, Nicola Aston, Ardeshir Bayat
The keloid lesion is recognised as a spatially heterogeneous mass both in cellular and acellular composition and biological activity. Here, we have utilised a bioinformatic approach to determine whether this spatial heterogeneity is also evident at the molecular level and to identify key upstream regulators of signalling pathways enriched in the lesion in a spatially-restricted manner. Differentia ...
Pages: 10-16
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INVESTIGATIVE REPORT
Expression of SOX18 in Mycosis Fungoides
Alina Jankowska-Konsur, Christopher Kobierzycki, Adam Reich, Aleksandra Piotrowska, Agnieszka Gomulkiewicz, Mateusz Olbromski, Marzena Podhorska-Okołów, Piotr Dzięgiel, Jacek C. Szepietowski
SOX18 is a transcription factor involved in the development of hair follicle, blood and lymphatic vessels, as well as regenerative processes. In addition, accumulated data indicate the role of SOX18 in tumourigenesis. So far, no studies on the role of SOX18 expression in mycosis fungoides (MF), the most common primary cutaneous T-cell lymphoma, have been performed. Therefore, we evaluated SOX18 ex ...
Pages: 17-23
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INVESTIGATIVE REPORT
The Reliability, Validity and Responsiveness of Two Disease Scores (BPDAI and ABSIS) for Bullous Pemphigoid: Which One to Use?
Asri Wijayanti, Cathy Y. Zhao, David Boettiger, Yi Z. Chiang, Norito Ishii, Takashi Hashimoto, Dedee F. Murrell
A significant obstacle in guiding evidence-based management of bullous pemphigoid (BP) is the lack of a standardised, validated scoring system for the condition. The aim of this study is to evaluate the suitability of the Bullous Pemphigoid Disease Area Index (BPDAI) and the Autoimmune Bullous Skin disorder Intensity Score (ABSIS) as outcome measures for BP in clinical trials. Thirty-two BP patien ...
Pages: 24-31
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INVESTIGATIVE REPORT
Bullous Pemphigoid: Validation of the National Patient Register in Two Counties in Sweden, 2001 to 2012
Carina Grönhagen, Karin Nilzén, Oliver Seifert, Kristofer Thorslund
Bullous pemphigoid (BP) is the most common autoimmune blistering disease. Since 2001, data from all specialized outpatient and inpatient care institutions in Sweden, have been registered with the National Patient Register (NPR), based on a unique personal identification number. Previous validations of the register have shown high accuracy for various non-dermatological autoimmune diseases. In orde ...
Pages: 32-35
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INVESTIGATIVE REPORT
Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype
Magdalena Trzeciak , Monika Sakowicz-Burkiewicz, Martyna Wesserling, Daria Dobaczewska, Jolanta Gleń, Roman Nowicki, Tadeusz Pawelczyk
Changes in the expression of cornified envelope (CE) proteins are thought to affect the development and course of atopic dermatitis (AD). The aim of this study was to examine the expression level of CE proteins in order to identify new molecular markers of the AD phenotype. Expression levels of CE proteins were evaluated in the skin of patients with AD (38 biopsies) and healthy subjects (26 biopsi ...
Pages: 36-41
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INVESTIGATIVE REPORT
Atopic Eczema and Stress among Single Parents and Families: An Empirical Study of 96 Mothers
Uwe Gieler, Stefanie Schoof, Tanja Gieler, Sibylle Scheewe, Christina Schut, Jörg Kupfer
This study investigated the extent to which single mothers of children with atopic eczema experience disease-related stress. A total of 96 mothers were divided into 4 groups: mothers living with a partner, who had or did not have a child with atopic eczema, and single mothers, who had or did not have a child with atopic eczema. The following questionnaires were used to assess psychological burden: ...
Pages: 42-46
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INVESTIGATIVE REPORT
Interleukin-31 Polymorphisms and Serum IL-31 Level in Patients with Mastocytosis: Correlation with Clinical Presen­tation and Pruritus
Magdalena Lange, Jolanta Gleń, Monika Zabłotna, Bogusław Nedoszytko, Małgorzata Sokołowska-Wojdyło, Krzysztof Rębała, Hanna Ługowska-Umer , Marek Niedoszytko, Aleksandra Górska, Monika Sikorska, Agata Zawadzka, Roman Nowicki
Data on interleukin-31 (IL-31) involvement in the patho-genesis of mastocytosis, and its impact on pruritus development in the disease, are limited. The aim of this study was to analyse distinct IL-31 gene polymorphisms in 127 patients (age 0.5–76 years) with mastocytosis and their correlation with clinical presentation, pruritus and serum IL-31 levels. In patients with mastocytosis, the frequen ...
Pages: 47-53
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INVESTIGATIVE REPORT
Inverse Association Between Atopy and Melanoma: A Case-control Study
Vivien Marasigan, Marie-Anne Morren, Julien Lambert, Karen Medaer, Steffen Fieuws, Tamar Nijsten, Marjan Garmyn
Heightened cutaneous immune surveillance in atopic patients may inhibit development of melanoma. The aim of this study was to analyse the association between atopy and melanoma (development and outcome). A total of 188 cases of melanoma and 596 healthy controls were interviewed by telephone with a standardized questionnaire on atopic, demographic and melanoma characteristics. Cases were matched wi ...
Pages: 54-57
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CLINICAL REPORT
Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study
Camilla Pasternack, Katri Kaukinen, Kalle Kurppa, Markku Mäki, Pekka Collin, Kaisa Hervonen, Timo Reunala, Heini Huhtala, Leila Kekkonen, Teea Salmi
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease. The burden of illness in untreated coeliac disease is known to be considerable, but corresponding evidence for DH is lacking. In this study the burden of DH was evaluated prospectively in 52 patients newly diagnosed with DH using a study questionnaire and a validated Psychological General Well-Being (PGWB) questi ...
Pages: 58-62
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CLINICAL REPORT
Antipruritic Effect of Cold-induced and Transient Receptor Potential-agonist-induced Counter-irritation on Histaminergic Itch in Humans
Hjalte H. Andersen, Camilla Melholt, Sigurd D. Hilborg, Anne Jerwiarz, Amalie Randers, Amalie Simoni, Jesper Elberling, Lars Arendt-Nielsen
A frequent empirical observation is that cold-induced counter-irritation may attenuate itch. The aim of this randomized, single-blinded, exploratory study was to evaluate the counter-irritation effects of cold-stimulation and topical application of transient receptor potential TRPA1/M8-agonists (trans-cinnamaldehyde/L-menthol, respectively), on histamine-induced itch, wheals and neurogenic inflamm ...
Pages: 63-70
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CLINICAL REPORT
Cost-effectiveness of an 8% Capsaicin Patch in the Treatment of Brachioradial Pruritus and Notalgia Paraesthetica, Two Forms of Neuropathic Pruritus
Sabine Steinke, Mandy Gutknecht, Claudia Zeidler, Anette Maria Dieckhöfer, Olga Herrlein, Hannah Lüling, Sonja Ständer, Matthias Augustin
In brachioradial pruritus and notalgia paraesthetica, the 8% capsaicin patch is a novel and effective, but cost-intense, therapy. Routine data for 44 patients were collected 6 months retrospectively and prospectively to first patch application. The cost to health insurance and the patient, and patient-reported outcomes were analysed (visual analogue scale, numerical rating scale, verbal rating sca ...
Pages: 71-76
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CLINICAL REPORT
Association Between Metabolic Syndrome and Atopic Dermatitis in Korean Adults
Ji Hyun Lee, Han Mi Jung, Kyung Do Han, Seung-Hwan Lee, Jun Young Lee, Yong Gyu Park, Young Min Park
Whether metabolic syndrome (MetS) and its components are risk factors for atopic dermatitis (AD) remains unclear. This study investigated the association between MetS and AD in Korean adults. Nationally representative data for 5,007 Korean adults, aged 19–40 years, from the cross-sectional Korea National Health and Nutrition Examination Survey 2010–2011 were analysed. AD in female patients was ...
Pages: 77-80
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CLINICAL REPORT
Living with Chronic Spontaneous Urticaria in Italy: A Narrative Medicine Project to Improve the Pathway of Patient Care
Antonietta Cappuccio, Tommaso Limonta, Aurora Parodi, Antonio Cristaudo, Filomena Bugliaro, Serafinella P. Cannavò, Oliviero Rossi, Carlotta Gurioli, Alice Vignoli, Roberta Parente, Enrico Iemoli, Giacomo Caldarola, Ornella De Pità, Sergio Di Nuzzo, Mauro Cancian, Concetta Potenza, Marco Caminati, Luca Stingeni, Rosita Saraceno, Sara Trevisini, Angelo Piccirillo, Claudio Sciarrone, Rosanna Panebianco, Massimo Gola, Antonio Costanzo, Teresa Grieco, Katia Massaroni, Luigi Reale, Maria G. Marini
Chronic spontaneous urticaria (CSU) is perceived as a difficult to manage disease with negative impact on quality of life. The aim of this study was to highlight how to improve the care of people with CSU, using the methodology of narrative medicine. From June 2014 to March 2015, CSU-diagnosed patients and their physicians were asked to record their experiences of the condition in writing. Fourtee ...
Pages: 81-85
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CLINICAL REPORT
What Factors are Important to Patients when Assessing Treatment Response: An International Cross-sectional Survey
Laura B. von Kobyletzki, Kim S. Thomas, Jochen Schmitt, Joanne R. Chalmers, Stefanie Deckert, Valeria Aoki, Elke Weisshaar, Jumoke Ahubelem Ojo, Åke Svensson
This study investigated the perspective of international patients on individual symptoms of atopic dermatitis (eczema) in determining treatment response. A questionnaire was developed to evaluate the importance of symptoms from the patient’s perspective. Patients were asked: “How important are these features in deciding whether or not a treatment is working?”, and rated symptoms on a 5-point ...
Pages: 86-90
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CLINICAL REPORT
Gender, Body Image and Social Support: Biopsychosocial Deter­minants of Depression Among Patients with Psoriasis
Ewa Wojtyna, Patryk Łakuta, Kamil Marcinkiewicz, Beata Bergler-Czop, Ligia Brzezińska-Wcisło
The aim of this study was to examine the importance of psychosocial factors, such as emotional and instrumental social support, distress, and assumptions about appearance and its salience to one’s self-worth, and to relate these factors to depressive symptoms in patients with psoriasis, according to gender. A group of 219 patients with psoriasis, aged 18–70 years completed the Beck Depression ...
Pages: 91-97
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CLINICAL REPORT
Exploring the Psychological Profile of Patients with Delusional Infestation
Reena Shah, Ruth E. Taylor, Anthony Bewley
Delusional infestation (DI) is an uncommon psychiatric disorder in which patients present with the false and fixed belief (i.e. a delusion) that their skin and/or their environment is infested despite objective evidence to the contrary. Within psychodermatology specialist clinics there is a high rate of DI referrals. What is not known is the level of psychiatric and psychological co-morbidities as ...
Pages: 98-101
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SHORT COMMUNICATION
Whole-Exome-Sequencing Reveals Small Deletions in CASP14 in Patients with Autosomal Recessive Inherited Ichthyosis
Peter Kirchmeier, Andreas Zimmer, Bakar Bouadjar, Bernd Rösler, Judith Fischer
Abstract is missing (Short communication)
Pages: 102-104
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SHORT COMMUNICATION
In-frame Exon Skipping in KRT5 due to Novel Intronic Deletion Causes Epidermolysis Bullosa Simplex, Generalized Severe
Katarzyna B. Gostyńska, Jeroen Bremer, Krista K. van Dijk-Bos, Richard Sinke, Anna Maria G. Pasmooij, Marcel F. Jonkman
Abstract is missing (Short communication)
Pages: 105-107
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SHORT COMMUNICATION
Hyaline Fibromatosis Syndrome: A Novel Mutation and Recurrent Founder Mutation in the CMG2/ANTXR2 Gene
Leila Youssefian, Hassan Vahidnezhad, Yahya Aghighi, Vahid Ziaee, Sirous Zeinali, Maryam Abiri, Jouni Uitto
Abstract is missing (Short communication)
Pages: 108-109
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SHORT COMMUNICATION
MEND Syndrome: A Case Report with Scanning Electron Microscopy Findings of the Collodion Membrane
Hiram de Almeida Jr, Cristina Has, Greice Rampon, Henrique Isaacsson, Luis Antonio Suita de Castro
Abstract is missing (Short communication)
Pages: 110-111
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SHORT COMMUNICATION
AT-rich Interaction Domain-containing Protein 3B is a New Tumour Marker for Melanoma
Satoshi Nakahara, Satoshi Fukushima, Junji Yamashita, Yosuke Kubo, Aki Tokuzumi, Azusa Miyashita, Miho Harada, Kayo Nakamura, Masatoshi Jinnin, Hironobu Ihn
Abstract is missing (Short communication)
Pages: 112-114
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SHORT COMMUNICATION
Eruptive Melanocytic Naevi Caused by Radotinib Therapy in Patients with Chronic Myeloid Leukaemia: 10 cases and a literature Review
Miri Kim, Young Hoon Yoon, Ji Hyun Lee, Dong Wook Kim, Hyun Jeong Park
Abstract is missing (Short communication)
Pages: 115-116
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SHORT COMMUNICATION
Dermoscopic Ulceration is a Predictor of Basal Cell Carcinoma Response to Imiquimod: A Retrospective Study
Marta Urech, Athanassios Kyrgidis, Giuseppe Argenziano, Camilla Reggiani, Elvira Moscarella, Caterina Longo, Roberto Alfano, Iris Zalaudek, Aimilios Lallas
Abstract is missing (Short communication)
Pages: 117-119
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SHORT COMMUNICATION
Long-term Outcome of Low-concentration Hexyl-5-aminolaevulinate Daylight Photodynamic Therapy for Treatment of Actinic Keratoses
Noora Neittaanmäki-Perttu, Toni Tapani Karppinen, Taneli Tani, Erna Snellman, Mari Grönroos
Abstract is missing (Short communication)
Pages: 120-121
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SHORT COMMUNICATION
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation
Yumeng Qi, Li Qiu, Song Zheng, Songbai LI, Ting Xiao
Abstract is missing (Short communication)
Pages: 122-123
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SHORT COMMUNICATION
Secukinumab in the Treatment of Generalized Pustular Psoriasis: A Case report
Sam Polesie, Anette Gente Lidholm
Abstract is missing (Short communication)
Pages: 124-125
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SHORT COMMUNICATION
Diagnosis and Treatment of Blau Syndrome/Early-onset Sarcoidosis, an Autoinflammatory Granulomatous Disease, in an Infant
Kristian B. Arvesen, Troels Herlin, Dorthe A. Larsen, Uffe Koppelhus, Mette Ramsing, Anne-Bine Skytte, Mette Sommerlund
Abstract is missing (Short communication)
Pages: 126-127
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SHORT COMMUNICATION
Value of BIOCHIP Technology in the Serological Diagnosis of Pemphigoid Gestationis
Christian D. Sadik, Hendri H. Pas, Michael K. Bohlmann, Sadegh Mousavi, Sandrine Benoit, Miklós Sárdy, Jorrit B. Terra, Ana L. Lima, Christoph M. Hammers, Nina van Beek, Christine Bangert, Detlef Zillikens, Enno Schmidt
Abstract is missing (Short communication)
Pages: 128-130
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SHORT COMMUNICATION
Clinical Outcomes of Punch-grafting for Chronic Leg and Foot Ulcers: A Retrospective Non-comparative Cohort Study
Lisa Groening, Livia Dunér Holthuis, Sam Polesie, Henrik H. Sönnergren
Abstract is missing (Short communication)
Pages: 131-132
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SHORT COMMUNICATION
Angiofibroma of Soft Tissue on the Cheek: Diagnosis Confirmed by Gene Rearrangement in NCOA2
Jin-Wook Jeong, Michihiro Kono, Yoshie Hasegawa-Murakami, Toru Motoi, Kenji Yokota, Takaaki Matsumoto, Kaori Kaibuchi-Ando, Yoichi Kato, Toyohiro Tada, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 133-134
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SHORT COMMUNICATION
Solitary Cutaneous Epithelioid Angiomatous Nodule Associated with Unilateral Capillary Malformation
Anastasiya A. Chokoeva, Georgi K. Maximov, Uwe Wollina, James W. Patterson, Georgi Tchernev
Abstract is missing (Short communication)
Pages: 135-136
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SHORT COMMUNICATION
Papulonecrotic Tuberculid: A Rare Skin Manifestation in a Child with Mesenteric Tuberculous Lymphadenopathy
Soo Hyeon Bae , Sook Jung Yun, Jee-Bum Lee, Seong-Jin Kim, Seung-Chul Lee, Young Ho Won
Abstract is missing (Short communication)
Pages: 137-138
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SHORT COMMUNICATION
Darier Disease Complicated by Terbinafine-resistant Trichophyton rubrum: A Case Report
Sanna S. Wingfield Digby, Marianne Hald, Maiken C. Arendrup, Sofie V. Hjort, Kristian Kofoed
Abstract is missing (Short communication)
Pages: 139-140
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SHORT COMMUNICATION
Usefulness of Serum Procalcitonin for Early Discrimination Between Necrotizing Fasciitis and Cellulitis
Takeshi Kato, Noriki Fujimoto, Shinichiro Honda, Norikazu Fujii, Masae Shirai, Takeshi Nakanishi, Gen Nakanishi, Toshihiro Tanaka
Abstract is missing (Short communication)
Pages: 141-142
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QUIZ
Silvery and Keratotic Plaque on the Glans Penis: A Quiz
Anaisa A.V. de Souza, Marcello M.S. Nico
Abstract is missing (Quiz)
Pages: 143-144
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LETTER TO THE EDITOR
Commentary on “Phimosis with Preputial Fissures as a Predictor of Undiagnosed Type 2 Diabetes in Adults”
Elisabet Nylander, Petra Tunbäck
Abstract is missing (Correspondence)
Pages: 145-146
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