Content

Content - Volume 98, Issue 3

Editor's choice in this issue

REVIEW
Treatment of Cutaneous Pseudolymphoma: A Systematic Review
Diana Miguel, Melanie Peckruhn, Peter Elsner
Cutaneous pseudolymphoma is a reactive polyclonal T- or B-cell lymphoproliferative process which may appear as a single lesion or disseminated. It can be classified based on its clinical features and while most cases are idiopathic, they can also be triggered by diverse extern factors. Prognosis is usually good, but if an antigenic stimulus is identified, it should be removed. We performed a systematic review summarizing all reported treatments for CPL.
Pages: 310-317
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INVESTIGATIVE REPORT
Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut
Minna Hietikko, Kaisa Hervonen, Tuire Ilus, Teea Salmi, Heini Huhtala, Kaija Laurila, Tiina Rauhavirta, Timo Reunala, Katri Kaukinen, Katri Lindfors
Coeliac disease and its cutaneous manifestation dermatitis herpetiformis (DH) are characterised by antibody responses against the major autoantigens transglutaminase (TG) 2 and its epidermal isoform, TG3, respectively. In this study, we investigated the different antibody responses in serum and small-intestinal mucosal biopsies obtained from DH and coeliac disease patients with active disease and in remission. We show that similarly to TG2 antibodies, TG3 antibodies can be detected not only in the serum but also in the organ culture medium of small-intestinal mucosal biopsies. Moreover, our results demonstrate the presence of TG3 antibody positive cells in the small bowel mucosa, suggesting that similarly to TG2 antibodies, TG3 antibody secretion also occurs in the small intestinal level, especially in active DH.
Pages: 366-372
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All articles

COMMENTARY
Classical Hand, Foot and Mouth Disease Replaced by Atypical Hand, Foot and Mouth Disease
Regina Fölster-Holst
Abstract is missing (Commentary)
Pages: 303-303
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COMMENTARY
Matrix-Assisted Laser Desorption/Ionisation Time-Of-Flight (MALDI-TOF) Mass Spectrometry in Dermatology
David Chandler, Roderick J. Hay
Abstract is missing (Commentary)
Pages: 304-304
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REVIEW
Treatment of Scleroedema Adultorum Buschke: A Systematic Review
Diana Miguel, Sibylle Schliemann, Peter Elsner
Scleroedema adultorum Buschke is a rare skin disease, which can be divided into 3 subtypes: classic type, occurring after respiratory infections; a type lacking association with infections; and a type associated with diabetes. Scleroedema adultorum Buschke is characterized by thickening and tightening of the skin, which typically starts at the neck. In half of patients, spontaneous remission may o ...
Pages: 305-309
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REVIEW
Treatment of Cutaneous Pseudolymphoma: A Systematic Review
Diana Miguel, Melanie Peckruhn, Peter Elsner
Cutaneous pseudolymphoma (CPL) is a reactive polyclonal T- or B-cell lymphoproliferative process. CPL may appear as localized or disseminated skin lesions. While most cases of CPL are idiopathic, they may also occur as a response to, for example, contact dermatitis, arthropod reactions, and bacterial infections. CPL can be classified based on its clinical features, but all variants have similar hi ...
Pages: 310-317
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REVIEW
Prostanoids and Hair Follicles: Implications for Therapy of Hair Disorders
Xue-Gang Xu, Hong-Duo Chen
Prostanoids, including prostaglandins (PGs) and thromboxane A2 (TXA2), are a family of lipid-derived autacoids that modulate many physiological systems and pathological contexts. Prostanoids are generated by sequential metabolism of arachidonic acid, catalysed by cyclo-oxygenase, to PGH2, which is then converted to PGD2, PGE2, PGF2α, PGI2 and TXA2, catalysed by their specific synthases. Recent ev ...
Pages: 318-323
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CLINICAL REPORT
Substance P Antagonist Aprepitant Shows no Additive Effect Compared with Standardized Topical Treatment Alone in Patients with Atopic Dermatitis
Louise Lönndahl, Mikael Holst, Maria Bradley, Hassan Killasli, Johan Heilborn, Martin A. Hall, Elvar Theodorsson, Jadwiga Holmberg, Klas Nordlind
Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus. Aprepitant is a NK-1 receptor antagonist. This open randomized trial evaluated the effect of aprepitant added to topical treatment in adult patients with moderate–severe AD. The treatment g ...
Pages: 324-328
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CLINICAL REPORT
Effects of a Hybrid Education Programme for Korean Mothers of Children with Atopic Dermatitis
Je-Bog Yoo, Jennie C. De Gagne, Seung-Hyeon S. Jeong, Chan-Woo Jeong
Atopic dermatitis (AD), a common childhood skin disorder, can limit a child’s learning and physical activities. South Korean mothers, as primary caregivers, experience anxiety and helplessness when caring for their ill children. The aim of this study was to develop a hybrid AD education programme (consisting of a face-to-face session followed by 8 online sessions) and evaluate its effects on anx ...
Pages: 329-334
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CLINICAL REPORT
Correlation Between Dermatology Life Quality Index and Psoriasis Area and Severity Index in Patients with Psoriasis Treated with Ustekinumab
Jeanette Halskou Hesselvig, Alexander Egeberg, Nikolai Dyrberg Loft, Claus Zachariae, Kristian Kofoed, Lone Skov
Monitoring of biological treatment efficacy for psoriasis is based on clinical evaluation and patient’s quality of life. However, long-term correlation between Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) in real life has not been studied in patients treated with ustekinumab. All patients with psoriasis treated with ustekinumab at our department were include ...
Pages: 335-339
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CLINICAL REPORT
Validation of the Itch Severity Item as a Measurement Tool for Pruritus in Patients with Psoriasis: Results from a Phase 3 Tofacitinib Program
Sonja Ständer, Thomas Luger, Joseph C. Cappelleri, Andrew G. Bushmakin, Carla Mamolo, Michael A. Zielinski, Anna M Tallman, Gil Yosipovitch
Tofacitinib is an oral Janus kinase inhibitor. This post-hoc analysis aimed to investigate the psychometric properties of the Itch Severity Item (ISI), a numeric rating scale from 0 (no itching) to 10 (worst possible itching) for pruritus in psoriasis, and review the effect of tofacitinib on pruritus in patients with psoriasis participating in Phase 3 studies (N = 3,641). The ISI showed high t ...
Pages: 340-345
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CLINICAL REPORT
Pain Quality Assessment Scale for Epidermolysis Bullosa
Nicholas H.B. Schräder, Wing Y. Yuen, Marcel F. Jonkman
Pain is one of the most debilitating symptoms in epidermolysis bullosa (EB) leading to reduced quality of life. Pain in EB comprises both neuropathic and non-neuropathic qualities. An assessment of pain qualities has not formerly been completed in EB. The Pain Quality Assessment Scale (PQAS) is an adjusted version of the validated Neuropathic Pain Scale and includes 20 pain qualities and descripto ...
Pages: 346-349
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CLINICAL REPORT
Atypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker
Hans-Henrik Horsten, Michael Kemp, Thea K. Fischer, Kim H. Lindahl, Anette Bygum
Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Derma ...
Pages: 350-354
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CLINICAL REPORT
Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria
Lauri Tolkki, Kati Hokynar, Seppo Meri, Jaana Panelius, Mirja Puolakkainen, Annamari Ranki
A retrospective study of 109 skin biopsies with granuloma annulare (GA) or morphea histology from patients with suspected tick bite was performed. Biopsies were tested for cutaneous Borrelia burgdorferi DNA using PCR. The same biopsies were analysed for tick-borne novel agents, Chlamydia-related bacteria (members of the Chlamydiales order), using a PCR-based method. Borrelia DNA was detected in 7/ ...
Pages: 355-360
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CLINICAL REPORT
Localized Scleroderma, Systemic Sclerosis and Cardiovascular Risk: A Danish Nationwide Cohort Study
Jeanette Halskou Hesselvig, Kristian Kofoed, Jashin J. Wu, Lene Dreyer, Gunnar Gislason, Ole Ahlehoff
Recent findings indicate that patients with systemic sclerosis have an increased risk of cardiovascular disease. To determine whether patients with systemic sclerosis or localized scleroderma are at increased risk of cardiovascular disease, a cohort study of the entire Danish population aged ≥ 18 and ≤ 100 years was conducted, followed from 1997 to 2011 by individual-level linkage of natio ...
Pages: 361-365
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INVESTIGATIVE REPORT
Ex vivo Culture of Duodenal Biopsies from Patients with Dermatitis Herpetiformis Indicates that Transglutaminase 3 Antibody Production Occurs in the Gut
Minna Hietikko, Kaisa Hervonen, Tuire Ilus, Teea Salmi, Heini Huhtala, Kaija Laurila, Tiina Rauhavirta, Timo Reunala, Katri Kaukinen, Katri Lindfors
Coeliac disease and dermatitis herpetiformis (DH) are characterized by autoantibodies targeting transglutaminase (TG)2 and TG3, respectively. Previous studies show that TG2 antibodies are produced in the gut and can be assessed in organ culture of small-intestinal biopsies from patients with coeliac disease. Thus far, no studies have investigated TG3 antibodies in organ culture of biopsies from pa ...
Pages: 366-372
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SHORT COMMUNICATION
Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema
Floor M. Garritsen, Jorien van der Schaft, Marlies de Graaf, Dirk Jan Hijnen, Carla A.F. Bruijnzeel-Koomen, Marcel P.H. van den Broek, Marjolein S. De Bruin-Weller
Abstract is missing (Short communication)
Pages: 373-375
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SHORT COMMUNICATION
Generalized Bullous Fixed Drug Eruption Following Metamizole (Re-)Exposure: A Medical Error-analytic Case Study
Peter Elsner, Maja Mockenhaupt
Abstract is missing (Short communication)
Pages: 376-377
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SHORT COMMUNICATION
Infectious Cellulitis Caused by Streptococcus halichoeri
Pascal Del Giudice, Céline Plainvert, Thomas Hubiche, Asmaa Tazi, Agnès Fribourg, Claire Poyart
Abstract is missing (Short communication)
Pages: 378-379
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SHORT COMMUNICATION
The Regibul Register: A Tool for Monitoring the Distribution and Incidence of Autoimmune Bullous Dermatoses in Three French Regions, 2010 to 2015
Jeffrey Loget, Coralie Barbe, Sophie Duvert-Lehembre, Christophe Bédane, Michaël Maizières, Pascal Joly, Amélie Couraud, Julie Plée, Philippe Bernard
Abstract is missing (Short communication)
Pages: 380-381
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SHORT COMMUNICATION
Incidence of Actinic Keratosis and Risk of Skin Cancer in Subjects with Actinic Keratosis: A Population-based Cohort Study
Ji Hyun Lee, Yeong Ho Kim, Kyung Do Han, Young Min Park, Jun Young Lee, Yong Gyu Park, Young Bok Lee
Abstract is missing (Short communication)
Pages: 382-383
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QUIZ
A Rapidly Expanding Ulcer in the Armpit of a 48-year-old Man: A Quiz
Yael Renert-Yuval, Sharon Merims, Alexander Maly, Yuval Ramot
Abstract is missing (Quiz)
Pages: 384-385
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QUIZ
Acquired Transverse Stripes on the Fingernails: A Quiz
Alya Alkhars, Marion Delaplace, Muriel Ouedraogo, Laurent Machet
Abstract is missing (Quiz)
Pages: 386-387
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