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Content - Volume 101, February

All articles

INVESTIGATIVE REPORT
Metabolomic Analysis of Skin Biopsies from Patients with Atopic Dermatitis Reveals Hallmarks of Inflammation, Disrupted Barrier Function and Oxidative Stress
Liis Ilves, Aigar Ottas, Bret Kaldvee, Kristi Abram, Ursel Soomets, Mihkel Zilmer, Viljar Jaks, Külli Kingo
The main objectives of this study were to characterize the metabolomic profile of lesional skin of patients with atopic dermatitis, and to compare it with non- lesional skin of patients with atopic dermatitis and skin of controls with no dermatological disease. Skin-punch biopsies were collected from 15 patients and 17 controls. Targeted analysis of 188 metabolites was conducted. A total of 77 met ...
Pages: 1-8
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SHORT COMMUNICATION
Statin Therapy and Vascular Inflammation Detected by Positron Emission Tomography/Computed Tomography in Patients with Psoriasis
Hannah Kaiser, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Kristoffer Mads Aaris Henningsen, Xing Wang, Christine Becker, Lone Skov, Peter Riis Hansen
Abstract is missing (Short communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Hyperspectral Imaging Reveals Spectral Differences and Can Distinguish Malignant Melanoma from Pigmented Basal Cell Carcinomas: A Pilot Study
Janne Räsänen, Mari Salmivuori, Ilkka Pölönen, Mari Grönroos, Noora Neittaanmäki
Pigmented basal cell carcinomas can be difficult to distinguish from melanocytic tumours. Hyperspectral imaging is a non-invasive imaging technique that measures the reflectance spectra of skin in vivo. The aim of this prospective pilot study was to use a convolutional neural network classifier in hyperspectral images for differential diagnosis between pigment­ed basal cell carcinomas and melanom ...
Pages: 1-8
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CLINICAL REPORT
Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study
Vivian Lindholm, Sari Pitkänen, Marika Schröder, Sonja Hahtola, Helka Sahi, Heini Halme, Kirsi Isoherranen
Previous research presents pulsed dye laser-mediated photodynamic therapy as a promising alternative to conventional red-light photodynamic therapy. In this study, 60 patients with 2 or more actinic keratoses randomly received either of these treatments on each side of the head. A physician blinded to the treatment evaluated treatment response at 6 months for each lesion, as completely, partially ...
Pages: 1-5
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INVESTIGATIVE REPORT
Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction
Manuel P. Pereira, Claudia Zeidler, Joanna Wallengren, Jon Anders Halvorsen, Elke Weisshaar, Simone Garcovich, Laurent Misery, Emilie Brenaut, Ekin Şavk, Nikolay Potekaev, Andrey Lvov, Svetlana Bobko, Jacek C. Szepietowski, Adam Reich, Agnieszka Bozek, Franz J. Legat, Martin Metz, Markus Streit, Esther Serra-Baldrich, Margarida Gonçalo, Michael Storck, Teresa Nau, Vincent Hoffmann, Sabine Steinke, Ina Greiwe, Martin Dugas, Matthias Augustin, Sonja Ständer
Chronic nodular prurigo is characterized by recalcitrant itch. Patient perspectives on therapeutic goals, satisfaction with therapy and efficacy of therapeutic regimens for this condition are unknown. This questionnaire study examined these issues in 406 patients with chronic nodular prurigo from 15 European dermatological centres. Improvements in itch, skin lesions and sleep were the most importa ...
Pages: 1-7
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CLINICAL REPORT
Treat-to-Target in Atopic Dermatitis: An International Consensus on a Set of Core Decision Points for Systemic Therapies
Marjolein De Bruin-Weller, Tilo Biedermann, Robert Bissonnette, Mette Deleuran, Peter Foley, Giampiero Girolomoni, Jana Hercogová, Chih-Ho Hong, Norito Katoh, Andrew E. Pink, Marie-Aleth Richard, Stephen Shumack, Juan F. Silvestre , Stephan Weidinger
Currently no treat-to-target framework to guide systemic treatment in adults with moderate-to-severe atopic dermatitis exists. We sought to reach international consensus through an eDelphi process on a core set of recommendations for such an approach. Recommendations were developed by an international Steering Committee, spanning 3 areas (Guiding Principles, Decision Making, and Outcome Thresholds ...
Pages: 1-7
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INVESTIGATIVE REPORT
Investigator’s Global Assessment of Chronic Prurigo: A New Instrument for Use in Clinical Trials
Claudia Zeidler, Manuel P. Pereira, Matthias Augustin, Mary Spellman, Sonja Ständer
Chronic prurigo is a pruritic disease characterized by the development of pruriginous lesions due to scratching. The number of lesions is representative of the stage of the disease, while the presence of excoriations reflects the scratching activity. Aim of this study was to validate a new developed tool for the objective assessment of chronic prurigo. Investigator’s Global Assessment scales for ...
Pages: 1-5
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QUIZ
Nodules on the Thigh after Brown Recluse Spider Venom Bite: A Quiz
Giacomo Dal Bello, Donatella Schena, Chiara Colato, Giampiero Girolomoni
Abstract is missing (Quiz)
Pages: 1-2
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CORRESPONDENCE
Commentary on “An Isolated Peculiar Gianotti-Crosti Rash in the Course of a COVID-19 Episode”
Stefano Veraldi, Andrea E. Beretta, Dario A. Marletta, Yiran Wei
Abstract is missing (Correspondence)
Pages: 1-2
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SHORT COMMUNICATION
Eruptive Pseudoangiomatosis: Clinicopathological Report of 20 Adult Cases and a Possible Novel Association with Parvovirus B19
Fatima Maqsood, Camilla Vassallo, Federica Derlino, Giorgio Alberto Croci, Christian Ciolfi, Valeria Brazzelli
Abstract is missing (Short communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Porokeratosis Plantaris, Palmaris et Disseminata Caused by Con- genital Pathogenic Variants in the MVD Gene and Loss of Hetero­zygosity in Affected Skin
Sabine Jägle, Hazem A. Juratli, Geoffroy Hickman, Kira Süssmuth, Maria C. Boente, Julia Kopp, Peter Kirchmeier, Andreas Zimmer, Rudolf Happle, Emmanuelle Bourrat, Henning Hamm, Judith Fischer
Porokeratoses are a heterogeneous group of keratinization disorders. For linear porokeratosis and disseminated superficial actinic porokeratosis, a heterozygous pathogenic germline variant in a mevalonate pathway gene and a postzygotic second hit mutation present in affected skin have been shown to be the patho­genetic mechanism for the development of the lesions. However, the molecular mechanism ...
Pages: 1-6
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SHORT COMMUNICATION
Retrospective Study of the Effectiveness of Azithromycin Single Dose Versus One-week Doxycycline for Anorectal Chlamydia in Men Who Have Sex with Men
Premnaath Torayraju, Kiran Kalidindi, Usha Hartgill, Harald Moi
Abstract is missing (Short Communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Assessment of Sclerodermoid Chronic Graft-versus-host Disease with Colour Doppler Ultrasound
Priscila Giavedoni, Carmen Martinez, Sebastian Podlipnik, María Suárez-Lleidó, Ignasi Martí-Martí, Daniel Morgado-Carrasco, Montserrat Rovira, Francesc Fernández-Avilés, Gonzalo Gutiérrez, Laura Rosiñol, Joan Cid, Miquel Lozano, José Manuel Mascaró, Jr.
Sclerodermoid chronic graft-versus-host disease (scGVHD) is a severe complication of allogeneic haema­- topoietic stem cell transplantation. The aim of this study was to investigate the usefulness of high-frequency ultrasound of the skin in assessing the inflammatory patterns and prognosis of patients with scGVHD. A prospective study was carried out with patients who developed scGVHD in the perio ...
Pages: 1-6
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QUIZ
Vesiculopustular Eruption in a Newborn with Down’s Syndrome: A Quiz
Léo Raffy, Clémence Elalouf, Marie-Christine Machet, Annabel Maruani
Abstract is missing (Quiz)
Pages: 1-2
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CLINICAL REPORT
Chlamydia trachomatis in Iceland: Prevalence, Clinico-epidemiological Features and Comparison of Cobas 480 CT/NG and Aptima Combo 2 (CT/NG) for Diagnosis
Ingibjorg Hilmarsdóttir, Eva Mjöll Arnardóttir, Elísabet Reykdal Jóhannesdóttir, Daniel Golparian, Magnus Unemo
The aims of this study were to assess the prevalence of, and risk factors for, Chlamydia trachomatis in attendees recruited prospectively from October 2018 to January 2019 at the only sexually transmitted infections clinic in Iceland (in Reykjavík), and to evaluate the cobas 4800 CT/NG Test and Aptima Combo 2 Assay for C. trachomatis detection in male urine and female vaginal swabs. Prevalence of ...
Pages: 1-6
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INVESTIGATIVE REPORT
Effect of Gentamicin Ointment in Patients with Nagashima-type Palmoplantar Keratosis: A Double-blind Vehicle-controlled Study
Yue Li, Xia Yu, Chaolan Pan, Yumeng Wang, Jianwen Han, Zhirong Yao, Ming Li
Gentamicin ointment has potential in the treatment of Nagashima-type palmoplantar keratosis. However, there is a lack of reliable study data. The aim of this study was to perform a prospective, randomized, double-blinded, contralateral, vehicle-controlled clinical trial. A total of 20 subjects diagnosed with Nagashima-type palmoplantar keratosis by genetic test, who carried nonsense mutations, enr ...
Pages: 1-5
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SHORT COMMUNICATION
Giant Condyloma Acuminatum Treated Successfully with Mild Local Hyperthermia: Two Case Reports
Zhen-Dong Wei, Yu-Zhe Sun, Rui-Qun Qi, Ming-Zhu Jin, Xing-Hua Gao
Abstract is missing (Short communication)
Pages: 1-2
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CLINICAL REPORT
Risk of Skin Cancer among Patients with Chronic Kidney Disease Treated with Ultraviolet B Phototherapy for Uraemic Pruritus: A Nationwide Cohort Study
Mei-Ju Ko, Jenq-Wen Huang, Hon-Yen Wu, Wan-Chuan Tsai, Le-Yin Hsu, Ping-Hsiu Tsai, Kuo-Liong Chien, Kuan-Yu Hung
The safety of ultraviolet B (UVB) phototherapy with respect to cutaneous carcinogenesis has not been established for patients with chronic kidney disease. To investigate this issue, a nationwide cohort study of 10,805 patients with advanced chronic kidney disease was conducted using data from the National Health Insurance of Taiwan, the Taiwan Cancer Registry, and the national death registry. Afte ...
Pages: 1-6
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SHORT COMMUNICATION
Improved Psychosocial Status after Surgery for Genital Elephantiasis due to Hidradenitis Suppurativa: A Prospective Study of a Case Series
Edyta Lelonek, Andrzej Bieniek, Łukasz Matusiak, Jacek C. Szepietowski
Abstract is missing (Short communication)
Pages: 1-3
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SHORT COMMUNICATION
Superficial CD34-positive Fibroblastic Tumour: Unique Subungual Presentation with Confounding Clinical Findings Resembling Fibrokeratoma-like Bowen’s Disease
Christophe Perrin, Florence Pedeutour, Bérengère Dadone-Montaudié, Damien Ambrosetti
Abstract is missing (Short communication)
Pages: 1-2
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SHORT COMMUNICATION
Utility of Melanin Degradation Products in the Nail for Diagnosing Nail Apparatus Melanoma
Tomoni Miyake, Akane Minagawa, Shosuke Ito, Yoshiharu Yokokawa, Kazumasa Wakamatsu, Ryuhei Okuyama
Abstract is missing (Short communication)
Pages: 1-2
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INVESTIGATIVE REPORT
IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes
Sofie Kaas Ovesen, Klaus Schulze-Osthoff, Lars Iversen, Claus Johansen
The interleukin (IL)-36 cytokine family plays an essential role in inflammatory processes in the skin and is implicated in the pathogenesis of psoriasis. This study explored the role of IL-36 in psoriasis and investigated the molecular mechanism involved in tumour necrosis factor-α (TNFα)/IL-17A-mediated IL-36 induction. In human keratinocytes IL-36 expression was strongly upregulated by combine ...
Pages: 1-8
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SHORT COMMUNICATION
Two-factor Oncogenesis in a Human Papillomavirus 68-associated Penile Carcinoma
Alexander Kreuter, Baki Akgül, Martin Hufbauer, Steffi Silling, Frank Oellig, Ulrike Wieland
Abstract is missing (Short communication)
Pages: 1-2
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CLINICAL REPORT
Benefit/risk Ratio of Low-dose Methotrexate in Cutaneous Lesions of Mycosis Fungoides and Sézary Syndrome
Fawaz Alenezi, Céline Girard, Didier Bessis, Bernard Guillot, Aurélie Du-Thanh, Olivier Dereure
Low-dose methotrexate is widely used in mycosis fungoides and Sézary syndrome, but few studies have evaluated this treatment. The aim of this study was to evaluate the benefit/risk ratio of this regimen on skin lesions. A retrospective survey of a series of patients treated for mycosis fungoides or Sézary syndrome with low-dose methotrexate and followed for at least one year in a tertiary referr ...
Pages: 1-6
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CLINICAL REPORT
Long-term Therapeutic Success of Intravenous Rituximab in 26 Patients with Indolent Primary Cutaneous B-cell Lymphoma
Stefanie Porkert, Pamela Mai, Constanze Jonak, Felix Weihsengruber, Klemens Rappersberger, Wolfgang Bauer, Ingrid Simonitsch-Klupp, Markus Raderer, Julia Valencak
Systemic monotherapy with rituximab is a well-known treatment approach for primary cutaneous follicle centre lymphoma and primary cutaneous marginal zone lymphoma. Both have excellent prognosis despite high relapse rates. To investigate the long-term effectiveness and clinical outcome of intravenous rituximab at a dose of 375 mg/m2 once weekly, data for 26 patients (17 primary cutaneous follicle c ...
Pages: 1-5
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CLINICAL REPORT
Granular Deposits of IgA in the Skin of Coeliac Patients Without Dermatitis Herpetiformis: A Prospective Multicentric Analysis
Emiliano Antiga, Roberto Maglie, Gabriele Lami, Alessandro Tozzi, Veronica Bonciolini, Francesca Calella, Beatrice Bianchi, Elena Del Bianco, Daniela Renzi, Edoardo Mazzarese, Antonino S. Calabrò, Marzia Caproni
Granular deposits of IgA represent the specific cutaneous marker of dermatitis herpetiformis. The prevalence of IgA deposits in the skin of patients with coeliac disease without dermatitis herpetiformis remains unknown. In this prospective case-control study, skin biopsies from newly diagnosed coeliac patients without dermatitis herpetiformis were analysed by direct immunofluorescence. Controls in ...
Pages: 1-7
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CLINICAL REPORT
Mohs Micrographic Surgery for Primary Versus Recurrent or Incompletely Excised Facial High-risk Basal Cell Carcinomas
Hannah Ceder, Malin Grönberg, John Paoli
Facial high-risk basal cell carcinomas are preferably treated with Mohs micrographic surgery, but only 10% of patients are offered Mohs micrographic surgery in Sweden. The aim of this retrospective study was to examine the differences between primary and recurrent or incompletely excised facial high-risk basal cell carcinomas undergoing Mohs micrographic surgery, with regard to the number of stage ...
Pages: 1-5
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