Content

Content - Volume 97, Issue 6

Editor's choice in this issue

INVESTIGATIVE REPORT
Quality of Life of Parents of Children with Atopic Dermatitis
Joanna Marciniak, Adam Reich, Jacek C. Szepietowski
Atopic dermatitis (AD) is the most common chronic dermatitis in children. The influence of AD on quality of life of parents of children with AD was studied using the Family Dermatology Life Quality Index (FDLQI). Fifty children with AD were included in the study (age range 2–24 months) together with their parents. Children’s AD was found to influence the quality of life of both parents; howeve ...
Pages: 711-714
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SHORT COMMUNICATION
Expression of Histidine Decarboxylase in the Epidermis of Primates with Chronic Itch
Yoshihiro Inami, Leigh Ann Nattkemper, Kent Sakai, Gil Yosipovitch, Tasuku Akiyama
Abstract is missing (Short communication)
Pages: 739-740
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All articles

INVESTIGATIVE REPORT
A Role for Neuregulin-1 in Promoting Keloid Fibroblast Migration via ErbB2-mediated Signaling
Natalie Jumper, Tom Hodgkinson, Ralf Paus, Ardeshir Bayat
Keloid disease is a fibroproliferative tumour characterised by aggressive local invasion, evident from a clinically and histologically active migrating margin. During combined laser capture microdissection and microarray analysis-based in situ gene expression profiling, we identified upregulation of the polypeptide growth factor neuregulin-1 (NRG1) and ErbB2 oncogene in keloid margin dermis, leadi ...
Pages: 675-684
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INVESTIGATIVE REPORT
Skin Microbiome in Small- and Large-plaque Parapsoriasis
Alexander Salava, Pedro Pereira, Velma Aho, Liisa Väkevä, Lars Paulin, Petri Auvinen, Annamari Ranki, Antti Lauerma
Staphylococcal enterotoxins have been shown to promote lymphoma-associated immune dysregulation. This study examined changes in the skin microbiome of parapsoriasis compared with intact skin. Swab microbiome specimens were taken of the parapsoriasis lesions of 13 patients. Control samples were taken from contralateral healthy sides of the body. Microbiotas were characterized by sequencing the V1 ...
Pages: 685-691
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INVESTIGATIVE REPORT
Differential Clinicopathological Features in Spontaneous Regression of Melanomas and Melanocytic Naevi
José M. Martín, Isabel Pinazo, Esperanza Jordá, Carlos Monteagudo
The aim of this study was to determine the clinical, histological and/or immunohistochemical features that enable differential diagnosis of regression of melanocytic naevi from regression of melanomas. All melanocytic neoplasms with histologically-confirmed regression diagnosed in our hospital between 2002 and 2009 were reviewed retrospectively. Lamellar and delicate fibrosis were associated with ...
Pages: 692-697
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INVESTIGATIVE REPORT
Basophil FcεRI Expression in Chronic Spontaneous Urticaria: A Potential Immunological Predictor of Response to Omalizumab Therapy
Gustavo Deza, Marta Bertolín-Colilla, Ramon M. Pujol, Laia Curto-Barredo, Dulce Soto, Maribel García, Pilar Hernández, Ramon Gimeno, Ana M. Giménez-Arnau
Although the efficacy of omalizumab has been clearly demonstrated in the treatment of chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement in CSU symptoms, is not entirely understood. This study investigated the effect of omalizumab on expression of the high-affinity IgE receptor (FcεRI) on blood basophils from patients with active CSU, and its associatio ...
Pages: 698-704
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INVESTIGATIVE REPORT
Routine Laboratory Parameter Dynamics and Laboratory Adverse Events in Psoriasis Patients on Long-term Treatment with Adalimumab, Etanercept, and Ustekinumab
Jochen H. O. Hoffmann, Christian Knoop, Alexander H. Enk, Eva N. Hadaschik
Only limited data on laboratory parameter dynamics and safety under prolonged biologic treatment in a “real-world” scenario are available for recommendations on screening and monitoring. This study is a retrospective analysis of routine parameter dynamics and laboratory adverse events (LAE) in psoriasis patients on long-term treatment (n = 199) with tumour necrosis factor (TNF)- ...
Pages: 705-710
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INVESTIGATIVE REPORT
Quality of Life of Parents of Children with Atopic Dermatitis
Joanna Marciniak, Adam Reich, Jacek C. Szepietowski
Atopic dermatitis (AD) is the most common chronic dermatitis in children. The influence of AD on quality of life of parents of children with AD was studied using the Family Dermatology Life Quality Index (FDLQI). Fifty children with AD were included in the study (age range 2–24 months) together with their parents. Children’s AD was found to influence the quality of life of both parents; howeve ...
Pages: 711-714
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CLINICAL REPORT
Multiple Primary Melanomas: A Common Occurrence in Western Sweden
Magdalena Claeson, Paul Holmström, Stefan Hallberg, Martin Gillstedt, Helena Gonzalez, Ann-Marie Wennberg, John Paoli
Patients diagnosed with a single primary cutaneous melanoma are at increased risk of developing multiple primary melanomas. The aim of this study is to describe the epidemiology of multiple primary melanomas (invasive and in situ) in Western Sweden. Data from the Swedish Melanoma Registry from 1990 to 2013 revealed that 898 patients (7.4%) developed 2,037 multiple primary lesions and 11,254 patien ...
Pages: 715-719
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CLINICAL REPORT
Familial Melanoma Associated with Li-Fraumeni Syndrome and Atypical Mole Syndrome: Total-body Digital Photography, Dermoscopy and Confocal Microscopy
Priscila Giavedoni, Marnie Ririe, Cristina Carrera, Susana Puig, Josep Malvehy
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder caused by a mutation in the p53 gene. Melanoma is considered to be a rare, controversial component of LFS. The aim of this study is to describe the utility of systematic screening for melanoma in patients with LFS and atypical mole syndrome. Two 28-year-old identical twin sisters with LFS and atypical moles were monitored by physical ...
Pages: 720-723
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CLINICAL REPORT
Risk of Non-melanoma Skin Cancer in Patients with Atopic Dermatitis Treated with Oral Immunosuppressive Drugs
Floor M. Garritsen, Jorien van der Schaft, Juul M. van den Reek, Klaziena Politiek, Harmieke van Os-Medendorp, Marijke van Dijk, Dirk J. Hijnen, Marlies de Graaf, Carla A. Bruijnzeel-Koomen, Elke M. de Jong, Marie-Louise A. Schuttelaar, Marjolein S. Bruin-Weller
There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunos ...
Pages: 724-730
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CLINICAL REPORT
Pattern and Severity of Psoriasiform Eruptions in Patients with Inflammatory Bowel Diseases, Arthritis or Skin Inflammatory Disorders Treated with TNF-alpha Inhibitors
Anne-Sophie Darrigade, Brigitte Milpied, Marie-Elise Truchetet, Thierry Schaeverbeke, David Laharie, Frank Zerbib, Marie Beylot-Barry, Thomas Jouary, Alain Taïeb, Khaled Ezzedine, Julien Seneschal
Psoriasiform eruptions are a classical adverse skin reaction of tumour necrosis factor (TNF)-α inhibitors. The aim of this study was to identify the association between the severity or pattern of psoriasiform reactions and the underlying disease. A retrospective study was conducted between January 2012 and May 2015. Adult patients who developed psoriasiform eruptions whilst being treated with ...
Pages: 731-734
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CLINICAL REPORT
Morbidity and Causes of Death in Patients with Cutaneous T-cell Lymphoma in Finland
Liisa Väkevä, Tuomas Lipsanen, Harri Sintonen, Annamari Ranki
Cutaneous T-cell lymphomas (CTCL), especially mycosis fungoides, can be considered as a state of longstanding low-grade systemic inflammation. Many studies have focused on secondary cancers with CTCL, but information about comorbidities is limited. A total of 144 patients with CTCL at Helsinki University Central Hospital during 2005 to 2015 were studied to determine associated comorbidities and ca ...
Pages: 735-738
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SHORT COMMUNICATION
Expression of Histidine Decarboxylase in the Epidermis of Primates with Chronic Itch
Yoshihiro Inami, Leigh Ann Nattkemper, Kent Sakai, Gil Yosipovitch, Tasuku Akiyama
Abstract is missing (Short communication)
Pages: 739-740
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SHORT COMMUNICATION
Keratinocyte Proliferation and Differentiation on IL-9 Stimulation: An Explorative In vitro Study
Hanna Niehues, Jos P.H. Smits, Diana Rodijk-Olthuis, Joost Schalkwijk, Ellen H. van den Bogaard
Abstract is missing (Short communication)
Pages: 741-742
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SHORT COMMUNICATION
GNA11-mutated and BAP1-negative Melanomas Ex Blue Naevi: A Particularly Aggressive Entity
Arnaud Uguen, Briac Guibourg, Sebastian Costa, Pascale Marcorelles
Abstract is missing (Short Communication)
Pages: 743-744
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SHORT COMMUNICATION
Naevoid Malignant Melanoma: A Diagnosis of a Naevus That You Later Regret
Grigorios Theodosiou, Iva Johansson, Nils Hamnerius, Åke Svensson
Abstract is missing (Short communication)
Pages: 745-746
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SHORT COMMUNICATION
Expression of Mucin 1 in Mycosis Fungoides Tumour Cells: A Case Report
Takushi Shirai, Yukiko Kiniwa, Shiho Asaka, Yasuyo Shimojo, Fuminao Kamijo, Ryuhei Okuyama
Abstract is missing (Short communication)
Pages: 747-748
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SHORT COMMUNICATION
Melanoma in Segmental Naevus Spilus: A Case Series and Literature Review
Monica C.T. Boot-Bloemen, Wim J.A. de Kort, Lidwine M.T. van der Spek-Keijser, Nicole A. Kukutsch
Abstract is missing (Short communication)
Pages: 749-750
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SHORT COMMUNICATION
Risk Factors for De Novo Squamous Cell Carcinoma Development in Renal Transplant Recipients with a Previous Squamous Cell Carcinoma
Vivan C. Hellström , Ylva Enström, Gunilla Enblad, Gunnar Tufveson, Henrik Renlund, Tomas Lorant, Filippa Nyberg
Abstract is missing (Short communication)
Pages: 751-753
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SHORT COMMUNICATION
Periocular Necrobiotic Xanthogranuloma Successfully Treated with Intravenous Immunoglobulin
Judit Lukács, Steven Goetze, Peter Elsner
Abstract is missing (Short communication)
Pages: 754-755
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SHORT COMMUNICATION
Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma
Akimasa Adachi, Mayumi Komine, Takeo Maekawa, Satoru Murata, Aiko Shiohama, Akiharu Kubo, Mamitaro Ohtsuki
Abstract is missing (Short communication)
Pages: 756-758
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SHORT COMMUNICATION
Tailoring the Cut-off Values of the Visual Analogue Scale and Numeric Rating Scale in Itch Assessment
Adam Reich, Evangelos Chatzigeorkidis, Claudia Zeidler, Nani Osada, Masutaka Furue, Kenji Takamori, Toshiya Ebata, Matthias Augustin, Jacek C. Szepietowski, Sonja Ständer
Abstract is missing (Short communication)
Pages: 759-760
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SHORT COMMUNICATION
Facial Manifestations of Pachydermoperiostosis Treated with Botulinum Toxin Type-A: Report of 3 Cases
Xiang Wen, Yong Li, Michael R. Hamblin, Xian Jiang
Abstract is missing (Short communication)
Pages: 761-762
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SHORT COMMUNICATION
Double-ended Pseudocomedones in Hidradenitis Suppurativa: Clinical, Dermoscopic, and Histopatho­logical Correlation
Francesco Lacarrubba, Maria L. Musumeci, Maria Rita Nasca, Anna Elisa Verzì, Federica Fiorentini, Giuseppe Micali
Abstract missing (Short communication)
Pages: 763-764
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SHORT COMMUNICATION
Fungal Melanonychia: Ungual Phaeohyphomycosis caused by Botryosphaeria dothidea
Hiromitsu Noguchi, Masataro Hiruma, Tadahiko Matsumoto, Rui Kano, Masaru Tanaka, Takashi Yaguchi, Kazuhiro Sonoda, Hironobu Ihn
Abstract is missing (Short communication)
Pages: 765-766
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SHORT COMMUNICATION
Insect Repellents and Contact Sensitization: An Observational Study
Monica Corazza, Annarosa Virgili, Alberto Maria Bertoldi, Giulia Toni, Dario Cristofaro, Alessandro Borghi
Abstract is missing (Short communication)
Pages: 767-768
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QUIZ
Brownish-grey, Papular Scaling Rash on the Trunk and Lower Limbs: A Quiz
Elena Marinello, Giulia Biolo, Roberto Salmaso, Anna Belloni Fortina, Dennis Linder, Stefano Piaserico
Abstract is missing (Quiz)
Pages: 769-771
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