Content

Content - Volume 98, Issue 7

Editor's choice in this issue

CLINICAL REPORT
Prognosis of Preschool Eczema and Factors of Importance for Remission
Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Erik Melén, Samina Asad, Maria Bradley, Agne Liedén, Natalia Ballardini, Carl-Fredrik Wahlgren
In a Swedish population-based birth cohort, half of children with preschool eczema (atopic dermatitis before age 4 years) were in complete remission by school age (from 4 to 16 years). Moreover, 8% had persistent eczema, and 41% had periods with and without eczema by school age. The most important prognostic factors were persistent preschool eczema (eczema at 1, 2, and 4 years), preschool eczema with sleep disturbance due to itch, and filaggrin mutation. These factors were strongly associated with reduced likelihood for remission by school age.
Pages: 630-635
Abstract  HTML  PDF
CLINICAL REPORT
Clinical Features of Chronic Spontaneous Urticaria that Predict Disease Prognosis and Refractoriness to Standard Treatment
Laia Curto-Barredo, Laura Riba Archilla, Guillem Roura Vives, Ramon M. Pujol, Ana M. Giménez-Arnau
Learning from our patients helps to develop a strategic plan of management. What we’ve learned from a cohort of 549 patients suffering Chronic Spontaneous Urticaria? First, clinical predictors of longer course include late onset of CSU (> 45 years old), concomitant chronic inducible urticaria, relapsing course showing multiples episodes of CSU, and a demonstrated serum autoreactivity. Second, most of the patients were refractory to second-generation antihistamines at licensed dose. Only baseline activity (UAS7) of the disease is useful to predict refractoriness to any H1-antihistamine at any dose. Complete control the disease requires then anti-IgE therapy as first choice or inmumodulation .
Pages: 641-647
Abstract  HTML  PDF

All articles

REVIEW
Effect of Age on Melanoma Risk, Prognosis and Treatment Response
Simone Ribero, Luigia Stefania Stucci, Elena Marra, Riccardo Marconcini, Francesco Spagnolo, Laura Orgiano, Virginia Picasso, Paola Queirolo, Guiseppe Palmieri, Pietro Quaglino, Veronique Bataille
As for all types of cancer, the incidence of melanoma increases with age. However, naevus counts (the principal risk factor for melanoma) decrease with age; hence the relationship between ageing and melanoma is complex. Subjects who maintain a high naevus count after the age of 50 years are more likely to be affected by melanoma, as their lesions do not senesce. Longer telomere length, which is st ...
Pages: 624-629
Abstract  HTML  PDF
CLINICAL REPORT
Prognosis of Preschool Eczema and Factors of Importance for Remission
Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Erik Melén, Samina Asad, Maria Bradley, Agne Liedén, Natalia Ballardini, Carl-Fredrik Wahlgren
Information on factors of importance for remission of eczema is scarce. This study explored factors related to the remission and course of preschool eczema (PSE) (eczema at 1, 2 and/or 4 years of age) to 16 years of age (n = 889) in a Swedish cohort. Half of the children were in complete remission by school age (at age 8, 12, and 16 years). In multivariate prognostic models, persistent PSE (ec ...
Pages: 630-635
Abstract  HTML  PDF
CLINICAL REPORT
Course and Predictors of Pruritus Following Burns: A Multilevel Analysis
Kelly A.A. Kwa, Anouk Pijpe, Zjir M. Rashaan, Wim E. Tuinebreijer, Roelf S. Breederveld, Nancy E. Van Loey
Itch is a common problem after burns. Although the topic receives increasing attention, the number of prospective studies is limited. The aim of this study was to assess the influence of acute traumatic stress symptoms, controlled for injury characteristics, age and sex, on itch over a period of 18 months using multilevel analysis. A total of 226 respondents provided itch scores. Participants comp ...
Pages: 636-640
Abstract  HTML  PDF
CLINICAL REPORT
Clinical Features of Chronic Spontaneous Urticaria that Predict Disease Prognosis and Refractoriness to Standard Treatment
Laia Curto-Barredo, Laura Riba Archilla, Guillem Roura Vives, Ramon M. Pujol, Ana M. Giménez-Arnau
Chronic spontaneous urticaria (CSU) is characterized by heterogeneous activity, evolution, associated comorbidities and response to treatment. The aim of this study was to identify prognostic factors in patients with CSU that predict disease course and response to standard treatments. An observational retrospective study was conducted in a cohort of 549 patients with CSU, comparing patients with i ...
Pages: 641-647
Abstract  HTML  PDF
CLINICAL REPORT
Initial Results of Secukinumab Drug Survival in Patients with Psoriasis: A Multicentre Daily Practice Cohort Study
Juul M.P.A. van den Reek, Lieke J. van Vugt, Martijn B.A. van Doorn, Gayle E. van der Kraaij, Wim J.A. de Kort, Georges P.H. Lucker, Barbara Horvath, M. David Njoo, H. Jorn Bovenschen, Paul M. Ossenkoppele , Marjolein S. De Bruin-Weller , Marjan de Groot, Roland Mommers, Ruud L.M.A. Prevoo, Peter C.M. van de Kerkhof, Phyllis I. Spuls, Wietske Kievit, Elke M.G.J. de Jong
Interleukin 17-antagonist secukinumab demonstrated high efficacy for treatment of psoriasis in randomized controlled trials. However, performance in daily practice may differ from trials. Drug survival is a comprehensive outcome covering effectiveness and safety, suitable for analyses of daily practice. The aim of this study was to evaluate drug survival of secukinumab in a daily practice psoriasi ...
Pages: 648-654
Abstract  HTML  PDF
CLINICAL REPORT
Auditory System Involvement in Psoriasis
Francesco Borgia, Francesco Ciodaro, Fabrizio Guarneri, Annunziata Bartolotta, Valeria Papaianni, Claudio Guarneri, Natalia Catalano, Francesco Galletti, Serafinella P. Cannavò
Psoriasis is a systemic inflammatory disorder associated with many other chronic and progressive diseases. There are few studies on the association of psoriasis with alterations in auditory function. A clinical and instrumental pilot study of auditory function was performed with 77 psoriatic patients and 77 age- and sex-matched healthy controls. The main results were: (i) hearing loss, mostly of s ...
Pages: 655-659
Abstract  HTML  PDF
CLINICAL REPORT
Structured Diagnostic Approach and Risk Assessment in Mucous Membrane Pemphigoid with Oesophageal Involvement
Sandrine Benoit, Michael Scheurlen, Matthias Goebeler, Johanna Stoevesandt
Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, U ...
Pages: 660-666
Abstract  HTML  PDF
CLINICAL REPORT
Unscheduled Visits of Patients with Familial Melanoma to a Pigmented Lesion Clinic: Evaluation of Patients' Characteristics and Suspicious Lesions
Rania Nabil, Elsemieke Plasmeijer, Remco van Doorn, Wilma Bergman, Nicole A. Kukutsch
Approximately 10% of all melanomas occur in subjects with a family history of melanoma. This retrospective follow-up study investigated the characteristics of patients with familial melanoma who made unscheduled visits to our pigmented lesions clinic, and the diagnosis of excised lesions. A total of 110 (9%) out of 1,267 patients made at least one unscheduled visit between May 2011 and February 20 ...
Pages: 667-670
Abstract  HTML  PDF
CLINICAL REPORT
Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma Series of 37 Cases and Systematic Review of the Literature
Raphael Lhote, Jérôme Lambert, Julie Lejeune, Jeremy Gottlieb, Antoine Badaoui, Maxime Battistella, Jennifer Roux, Cecile Pages, Laetitia Vercellino, Catherine Vilmer, Christine Le Maignan, Catherine Escande, Besma MBarek, Martine Bagot, Celeste Lebbé, Nicole Basset-Seguin
Cutaneous squamous cell carcinoma (cSSC) is one of the most common skin cancers and can lead to patient death. Early detection of node metastasis is a major goal for dermatologists and oncologists. The procedure sentinel lymph node biopsy has been proposed to improve early detection of node metastasis. The aim of this study was to evaluate the efficacy and impact of this technique on the prognosis ...
Pages: 671-676
Abstract  HTML  PDF
CLINICAL REPORT
Lower-limb Ulcers in Systemic Sclerosis: A Multicentre Retrospective Case-control Study
Gérôme Bohelay, Sophie Blaise, Pierre Levy, Antoine Claeys, Nathalie Baudot, Jean-Francois Cuny, Hervé Maillard, Florence Granel-Brocard, Thierry Boyé, Catherine Lok, Nathalie Bénéton, Camille Francès, Patricia Senet
Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischaemic causes (arterial disease and/or microvascular impairment). A retrospective, multicentre, case-control study was conducted in 2013 and 2014, including 45 systemic s ...
Pages: 677-682
Abstract  HTML  PDF
CLINICAL REPORT
A Clinical Prediction Model for Surgical Site Infections in Dermatological Surgery
Xiaomeng Liu, Nicole W.J. Kelleners-Smeets, Melissa Sprengers, Vishal Hira, Klara Mosterd, Patty J. Nelemans
To adequately identify patients at risk for surgical site infection in dermatological surgery and effectively prescribe antibiotic prophylaxis, a prediction model may be helpful. Such a model was developed using data from 1,407 patients who underwent dermatological surgery without antibiotic prophylaxis. The multivariable logistic regression model included type of closure, tumour location and defe ...
Pages: 683-688
Abstract  HTML  PDF
CLINICAL REPORT
Treatment of Actinic Keratosis with Photodynamic Therapy Using Red or Green Light: A Comparative Study
Beata J. Osiecka, Piotr Nockowski, Jacek C. Szepietowski
Actinic keratosis (AK) is the most common in situ cancerous skin lesion. Compared with other approved treatment modalities photodynamic therapy is preferred by patients due to faster recovery and improved cosmetic outcome. However, pain during irradiation is an important drawback. The aim of this study was to compare the effectiveness and tolerability of topical aminolaevulinic acid-photodynamic t ...
Pages: 689-693
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles
Shiro Niiyama, Yumiko Ishimatsu-Tsuji, Yosuke Nakazawa, Yuzo Yoshida, Tsutomu Soma, Ritsuro Ideta, Hideki Mukai, Jiro Kishimoto
Cells that constitute the dermal papillae of hair follicles might be derived from the dermal sheath, the peribulbar component of which is the dermal sheath cup. The dermal sheath cup is thought to include the progenitor cells of the dermal papillae and possesses hair inductive potential; however, it has not yet been well characterized. This study investigated the gene expression profile of the int ...
Pages: 694-698
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Outcome of Combined Treatment of Surgery and Adjuvant Radiotherapy in Merkel Cell Carcinoma
Eckhard Fiedler, Dirk Vordermark
In recent analyses of Merkel cell carcinoma, prognosis is poor even in stages I and II. We performed a monocentric retrospective study of 37 consecutive cases with Merkel cell carcinoma stage I to III treated with a combination of surgery and adjuvant radiation to evaluate progression-free and overall survival. The median primary tumour diameter was 17.9 mm. Cases consisted of 31 primary tumours, ...
Pages: 699-703
Abstract  HTML  PDF
SHORT COMMUNICATION
Isolated Adrenocorticotropic Hormone Deficiency in Melanoma Patients Treated with Nivolumab
Seiya Kitano, Kazuki Tatsuno, Junichi Ishibe, Takatoshi Shimauchi, Toshiharu Fujiyama, Taisuke Ito, Noriyoshi Ogawa, Yoshiki Tokura
Abstract is missing (Short communication)
Pages: 704-705
Abstract  HTML  PDF
SHORT COMMUNICATION
Serum Carcinoembryonic Antigen Level as a Marker for Advanced Stage and Chemotherapeutic Response in Extramammary Paget's Disease
Hiroshi Umemura, Osamu Yamasaki, Tatsuya Kaji, Masaki Otsuka, Kenji Asagoe, Keiji Iwatsuki
Abstract is missing (Short communication)
Pages: 706-707
Abstract  HTML  PDF
SHORT COMMUNICATION
Identification of Antibacterial Components in Human Hair Shafts
Roopa S. Subbaiah, Swat Kim Kerk, Yilong Lian, Declan Lunny, Siu Kwan Sze, Kee Woei Ng, Artur Schmidtchen, Sunil S. Adav
Abstract is missing (Short communication)
Pages: 708-710
Abstract  HTML  PDF
SHORT COMMUNICATION
Successful Multidisciplinary Treatment of Chronic Facial Wounds in Junctional Epidermolysis Bullosa
Antonia Reimer, Roland Laszig, Jens Pfeiffer, Philipp Eberwein, Hans Mittelviefhaus, Leena Bruckner-Tuderman, Cristina Has
Abstract is missing (Short communication)
Pages: 711-712
Abstract  HTML  PDF
SHORT COMMUNICATION
Patient Burden is Associated with Alterations in Quality of Life in Adult Patients with Atopic Dermatitis: Results from the ECLA Study
Laurent Misery, Julien Seneschal, Ziad Reguiai, Stéphanie Merhand, Stéphane Héas, Flavien Huet, Charles Taïeb, Khaled Ezzedine
Abstract is missing (Short communication)
Pages: 713-714
Abstract  HTML  PDF
SHORT COMMUNICATION
Two Minimal Clinically Important Difference (2MCID): A New Twist on an Old Concept
Faraz M. Ali, M. Sam Salek, Andrew Y. Finlay
Abstract is missing (Short communication)
Pages: 715-717
Abstract  HTML  PDF
CORRESPONDENCE
Hand, Foot and Mouth Disease and Echovirus 3: A Comment to Høgsberg & Bygum
Pascal Del Giudice, Thomas Hubiche
Abstract is missing (Correspondence)
Pages: 718-718
Abstract  HTML  PDF
IN THIS ISSUE
Painful Erythematous-violaceous Toe: A Quiz
Sarah Ventejou, Marion Delaplace, Philippe Dehayes, Elodie Bailly, Laurent Machet
Abstract is missing (Quiz)
Pages: 719-720
Abstract  HTML  PDF