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Content - Volume 100, October

Editor's choice in this issue

INVESTIGATIVE REPORT
Ten-year Follow-up Study of Grenz Ray Treatment for Lentigo Maligna and Early Lentigo Maligna Melanoma
Iara R.T. Drakensjö, Einar Rosen, Margareta Frohm Nilsson, Ada Girnita
Grenz Rays have been successfully used in patients with lentigo maligna at the department of Dermatology at the Karolinska University Hospital since 1990, and we have treated more than 1,000 patients. The method is well tolerated, simple to perform, and has an excellent cosmetic outcome. With this study we would like to highlight the safety and long-term efficacy of Grenz Rays for the treatment of lentigo maligna, especially for cases where surgery is complex to perform.
Pages: 1-5
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All articles

SPECIAL REPORT
NEWSLETTER (October 2020)
Pages: 1-2
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INVESTIGATIVE REPORT
Tissue-remodelling M2 Macrophages Recruits Matrix Metallo­proteinase-9 for Cryotherapy-induced Fibrotic Resolution during Keloid Treatment
Young In Lee, Soo Min Kim, Jihee Kim, Jemin Kim, Seung Yong Song, Won Jai Lee, Ju Hee Lee
Cryotherapy is used to treat keloid scars; however, the molecular and pathological mechanisms are not clearly understood. This study retrospectively evaluated the efficacy of combined treatment with cryotherapy and intralesional triamcinolone injection (Cryo+TA) or intralesional TA monotherapy (TA) in 40 Asian patients with keloid scars. Scar improvement was assessed using the Vancouver Scar Scale ...
Pages: 1-8
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INVESTIGATIVE REPORT
Incidence of Kaposi Sarcoma in Sweden is Decreasing
Giedre Bieliauskiene, Oscar Zaar, Isabel Kolmodin, Martin Gillstedt, John Paoli
Kaposi sarcoma is a rare skin cancer, and epidemiological research into Kaposi sarcoma is therefore scarce. The current epidemiological situation for Kaposi sarcoma in Sweden is unknown. The authors hypothesized that the incidence of Kaposi sarcoma should have decreased after the introduction of antiretroviral therapy in 1996. Using data from the Swedish Cancer Registry, this study aimed to determ ...
Pages: 1-6
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QUIZ
Ulcerated Papules, Plaques and Nodules on the Extremities and Trunk of a Male Patient: A Quiz
Špela Baglama, Katarina Trčko
Abstract is missing (Quiz)
Pages: 1-2
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INVESTIGATIVE REPORT
Incidence of Lichen Planus and Subsequent Mortality in Finnish Women
Pia Halonen, Maija Jakobsson, Oskari Heikinheimo, Mika Gissler, Eero Pukkala
The incidence pattern of lichen planus (LP) and LP-related mortality are unknown. The aim of this study was to assess these factors, based on Finnish nationwide registry data including 13,378 women with LP diagnosed during 1969 to 2012. The incidence rate for LP in 2003 to 2012 was 28 per 100,000 woman-years age-adjusted to the European Standard Population. Mortality was assessed using the standar ...
Pages: 1-5
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INVESTIGATIVE REPORT
Transcutaneous Slowly Depolarizing Currents Elicit Pruritus in Patients with Atopic Dermatitis
Roman Rukwied, Mark Schnakenberg, Hans Jürgen Solinkski, Martin Schmelz, Elke Weisshaar
Slowly depolarizing currents applied for one minute have been shown to activate C-nociceptors and provoke increasing pain in patients with neuropathy. This study examined the effect of transcutaneous slowly depolarizing currents on pruritus in patients with atopic dermatitis. C-nociceptor-specific electrical stimu­lation was applied to areas of eczema-affected and non-affected skin in 26 patients ...
Pages: 1-6
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SHORT COMMUNICATION
Remission of Anti-laminin 332 Mucous Membrane Pemphigoid Associated with Non-small Cell Lung Cancer after Therapy with Rituximab and Intravenous Immunoglobulin
Evelyne Tarnowietzki, Thorsten Peters, Lea Kraus, Enno Schmidt, Karin Scharffetter-Kochanek
Abstract is missing (Short communication)
Pages: 1-2
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CLINICAL REPORT
Cardiovascular Risk and Comorbidities in Patients with Rosacea: A Systematic Review and Meta-analysis
Tsung-Yu Tsai, Ying-Yi Chiang, Yu-Chen Huang
The association between rosacea and cardiovascular disease remains controversial. A systematic review and meta-analysis of the literature, from inception to 15 February 2020, was performed to compare cardiovascular risk and comorbidities in individuals with and without rosacea. Twelve studies, involving 40,752 patients with rosacea, were included. Compared with controls, patients with rosacea had ...
Pages: 1-7
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INVESTIGATIVE REPORT
Massively Parallel Sequencingof the Filaggrin Gene Reveals an Association Between FLG Loss-of-function Mutations and Leprosy
Wenhao Shi, Zihao Mi, Zhenzhen Wang, Huimin Zhang, Na Wang, Zhe Wang, Bowen Zhang, Qianqian Xia, Yueqian Yu, Gongqi Yu, Lele Sun, Xian Fu, Chuan Wang, Hong Liu, Furen Zhang
Filaggrin, encoded by the FLG gene, plays a crucial role in the barrier function of epidermis, but the association between FLG loss-of-function mutations and infectious skin diseases has not been systematically studied. FLG coding sequences from 945 patients with leprosy and 916 healthy controls were captured and enriched using an array-based high-throughput system, and subjected to next-generatio ...
Pages: 1-5
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CLINICAL REPORT
Intravenous Immunoglobulins in a Series of 32 Rare and Recalcitrant Immune Dermatoses
Roberta Scarpone, Katharina Meier, Kamran Ghoreschi, Margitta Worm
Intravenous immunoglobulins are an effective and well-tolerated treatment option for immune dermatological diseases. However, they are primarily used to treat diseases with a severe course and are mostly used off-label. Therefore, it is important to document case series on the use of intravenous immunoglobulins in rare immune dermatological diseases. We present here 32 patients who were treated wi ...
Pages: 1-6
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SHORT COMMUNICATION
Validation of Psoriasis Diagnoses Recorded in Finnish Biobanks
Suvi Haverinen, Armi Vihervaara, Eliisa Löyttyniemi, Sirkku Peltonen, Leena Koulu, Kaisa Tasanen, Laura Huilaja, for the FinnGen investigators
Abstract is missing (Short communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Risk Factors for the Co-infection with HIV, Hepatitis B and C Virus in Syphilis Patients
Hui-Zi Gong, Kui-Ru Hu, Wei Lyu, He-Yi Zheng , Wei Guo Zhu, Xia Wan, Jun Li
Syphilis, human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) share transmission routes. Syphilis infection can increase the risk of acquiring and transmitting HIV in key populations. The aims of this study were to investigate the risk factors and co-infection patterns for HIV, HBV and HCV in patients with syphilis. A retrospective study was conducted of 2,412 p ...
Pages: 1-6
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CLINICAL REPORT
Antibiotic Susceptibility of Cutibacterium acnes Strains Isolated from Israeli Acne Patients
Sivan Sheffer-Levi, Amit Rimon, Vanda Lerer, Tehila Shlomov, Shunit Coppenhagen-Glazer, Chani Rakov, Tamara Zeiter, Ran Nir-Paz, Ronen Hazan, Vered Molcho-Pessach
Antibiotic-resistant Cutibacterium acnes has been reported worldwide, but data from Israeli patients with acne is currently lacking. This study evaluated the antibiotic susceptibility of C. acnes, isolated from 50 Israeli patients with acne to commonly prescribed antibiotics, using the Epsilometer test (E-test). Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis, 16S r ...
Pages: 1-8
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CLINICAL REPORT
Impact of Atopic Dermatitis in Adolescents and their Parents: A French Study
Khaled Ezzedine, Jason Shourick, Stéphanie Merhand, Francesca Sampogna, Charles Taïeb
Atopic dermatitis has a negative impact on quality of life in patients and their families. However, there have been very few studies of the impact of atopic dermatitis on adolescents and their relatives. The objective of this study was to evaluate the impact of atopic dermatitis in the daily lives of adolescents between 12 and 17 years of age in the French population and to assess the burden of th ...
Pages: 1-7
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INVESTIGATIVE REPORT
Increased Risk of Pemphigus among Patients with Psoriasis: A Large-scale Cohort Study
Khalaf Kridin, Ralf J. Ludwig, Giovanni Damiani, Arnon D. Cohen
Although pemphigus has recently been linked to psoriasis, the risk of emergence of pemphigus during the course of psoriasis is yet to be delineated. The aim of this study was to evaluate the risk of developing pemphigus during the course of psoriasis. A large-scale population-based longitudinal retrospective cohort study was performed to assess the hazard ratio (HR) of pemphigus among 68,836 patie ...
Pages: 1-4
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CLINICAL REPORT
Risk Factors for Seborrhoeic Dermatitis Flares: Case-control and Case-crossover Study
Rémi Lancar, Pascale Missy, Alain Dupuy, Philippe Beaulieu, Laurence Fardet, Dominique Costagliola, Olivier Chosidow
Patients with flares of seborrhoeic dermatitis were compared with control outpatients seen during the same time-period in a case-control study, and with themselves while in remission in a case-crossover study. All patients consulted the same office-based dermatologist. During the study period, 189 cases and 189 controls were included in the case-control study, and 81 cases in the case-crossover st ...
Pages: 1-5
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REVIEW
Itch Relief in Atopic Dermatitis: Comparison of Narrowband Ultraviolet B Radiation and Cyclosporine Treatment
Andrzej Jaworek, Krystyna Szafraniec, Magdalena Jaworek, Łukasz Matusiak, Anna Wojas-Pelc, Jacek C. Szepietowski
Abstract is missing (Short communication)
Pages: 1-3
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CLINICAL REPORT
Quality of Life of Cohabitants of People Living with Acne
Eliseo Martínez-García, Salvador Arias-Santiago, Enrique Herrera-Acosta, Andrew Affleck, Enrique Herrera-Ceballos, Agustin Buendía-Eisman
The aim of this study was to analyse the levels of anxiety, depression, and quality of life of individuals living with acne patients (cohabitants). The study included patients, cohabitants, and controls; a total of 204 participants. Patients’ health-related quality of life was measured with the Dermatology Life Quality Index (DLQI), while cohabitants’ quality of life was measured with the Fami ...
Pages: 1-6
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INVESTIGATIVE REPORT
Increased Risk of Squamous Cell Carcinoma of the Skin and Lymphoma Among 5,739 Patients with Bullous Pemphigoid: A Swedish Nationwide Cohort Study
Zeyad Albadri, Kristofer Thorslund, Henrike Häbel, Oliver Seifert, Carina Grönhagen
Evidence about the association of bullous pemphigoid and the risk of cancer is conflicting. Patients diagnosed with bullous pemphigoid (n = 5,739) between 2005 and 2016 were matched with a control cohort from the general population (n = 17,168) to estimate their overall and specific risk of cancer. The risk of squamous cell cancer of the skin (cSCC) was increased in patients with bullous p ...
Pages: 1-6
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QUIZ
Soft, Erythematous Nodule of the Ankle with a String of Pearls Vascular Pattern: A Quiz
Emanuele Cozzani, Astrid Herzum, Roberto Russo, Claudia Micalizzi, Giulia Scaglione, Francesco Cabiddu, Aurora Parodi
Abstract is missing (Quiz)
Pages: 1-2
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SHORT COMMUNICATION
Polypoidal Manifestation of Multiple Poromas: Possible Drug Involvement
Yuichi Yoshida, Nanako Yamada, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 1-2
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CLINICAL REPORT
Efficacy of Repeated Courses of Rituximab as Treatment for Pemphigus Vulgaris
Sharon Baum, Tal Raviv, Sarit Gilboa, Felix Pavlotsky, Aviv Barzilai
Rituximab targets the B-lymphocyte antigen CD20, providing pemphigus vulgaris patients with long-term remissions. However, the effects of repeated courses have not yet been established. This study aimed to evaluate the effect of repeated rituximab courses on remission length in pemphigus vulgaris. A total of 73 patients with pemphigus vulgaris treated with rituximab at a single centre were retrosp ...
Pages: 1-6
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SHORT COMMUNICATION
Novel TGM1 Gene Mutation in a Japanese Patient with Bathing Suit Ichthyosis
Naomi Tani, Nanako Yamada, Tetsuya Okazaki, Takashi Horie, Hajime Nakano, Daisuke Sawamura, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 1-2
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CLINICAL REPORT
Locoregional Lymph Node Recurrence of Trunk Melanoma in Non-sentinel Lymph Node Basins: An Observational Retrospective Study
Ruggero Moro, Jessica González-Ramos, Silvestre Martínez-García, Celia Requena, Victor Traves, Esperanza Manrique-Silva, Eduardo Nagore
Locoregional lymph node recurrences of primary trunk melanoma can occur in basins not identified during sentinel lymph node biopsy. However, the factors associated with recurrences in non-sentinel lymph node basins are unknown. To evaluate these factors, this observational retrospective study examined the patterns of first lymph node recurrence and the factors associated with recurrence in non-sen ...
Pages: 1-6
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SHORT COMMUNICATION
A Novel NCSTN Gene Mutation in a Japanese Family with Hidradenitis Suppurativa
Nobuyuki Nishimori, Koremasa Hayama, Kumiko Kimura, Hideki Fujita, Kyoko Fujiwara, Tadashi Terui
Abstract is missing (Short communication)
Pages: 1-2
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INVESTIGATIVE REPORT
Ten-year Follow-up Study of Grenz Ray Treatment for Lentigo Maligna and Early Lentigo Maligna Melanoma
Iara R.T. Drakensjö, Einar Rosen, Margareta Frohm Nilsson, Ada Girnita
Radiotherapy is often used to treat lentigo maligna. However, the long-term efficacy and safety of radiotherapy approaches have not been thoroughly evaluated. We aimed to evaluate the long-term efficacy and safety of ultrasoft X-ray/Grenz ray treatment in those patients. A total of 161 lesions from 159 patients received treatment with Grenz ray between 2005 and 2007. Follow-up of recurrence was pe ...
Pages: 1-5
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INVESTIGATIVE REPORT
Neutrophil Extracellular Traps are Present in Immune-complex-mediated Cutaneous Small Vessel Vasculitis and Correlate with the Production of Reactive Oxygen Species and the Severity of Vessel Damage
Christina Bergqvist, Rémi Safi, George El Hasbani, Ossama Abbas, Abdulghani Kibbi, Dany Nassar
Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histology-proven hypersensitivity vasculitis (n = 21), IgA vasculitis (n = 22) ...
Pages: 1-7
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