Content

Content - Volume 97, Issue 7

Editor's choice in this issue

INVESTIGATIVE REPORT
Advanced Glycation End Products are Increased in the Skin and Blood of Patients with Severe Psoriasis
Anastasia Papagrigoraki, Micol Del Giglio, Chiara Cosma, Martina Maurelli, Giampiero Girolomoni, Annunziata Lapolla
Psoriasis is frequently associated with metabolic comorbidities. Advanced glycation end products (AGEs) are highly oxidant, biologically active compounds that accumulate in tissues in association with hyperglycaemia, hyperlipidaemia and oxidative stress. This is a cross-sectional case-control study involving 80 patients with mild/severe psoriasis and 80 controls matched for age, sex and body mass ...
Pages: 782-787
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INVESTIGATIVE REPORT
Variation in Staphylococcus aureus Colonization in Relation to Disease Severity in Adults with Atopic Dermatitis during a Five-month Follow-up
Mikael Alsterholm, Louise Strömbeck, Annika Ljung, Nahid Karami, Johan Widjestam, Martin Gillstedt, Christina Åhren, Jan Faergemann
The aim of this study was to monitor Staphylococcus aureus colonization and disease severity in adults with atopic dermatitis (AD) during 5 months. Twenty-one patients attended 3 visits each for severity SCORing of Atopic Dermatitis (SCORAD) assessment, quantitative cultures from the skin and conventional cultures from the anterior nares, tonsils and perineum. S. aureus isolates were typed for str ...
Pages: 802-807
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CLINICAL REPORT
Clinical Spectrum, Quality of Life, BRAF Mutation Status and Treatment of Skin Involvement in Adult Langerhans Cell Histiocytosis
Etienne Crickx, Jean-David Bouaziz, Gwenaël Lorillon, Mathilde de Menthon, Florence Cordoliani, Emmanuell Bugnet, Martine Bagot, Michel Rybojad, Samia Mourah, Abdellatif Tazi
Langerhans cell histiocytosis is a rare histiocytic disorder for which skin involvement and management are poorly described in adults. The aim of this retrospective monocentric study in a national reference centre is to describe the clinical characteristics, quality of life, BRAF mutation status and outcomes of skin involvement in adult patients with Langerhans cell histiocytosis. Twenty-five pati ...
Pages: 838-842
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All articles

IN THIS ISSUE
The AGEs of Psoriasis: A Biomarker for Severity and a Pathogenetic Link to Comorbidities
Lluís Puig, Anna López-Ferrer
Abstract is missing (In this Issue)
Page: 775
Abstract  PDF
CLINICAL REPORT
Efficacy and Safety of Tranexamic Acid in Melasma: A Meta-analysis and Systematic Review
Hyun Jung Kim, Seok Hoon Moon, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MA ...
Pages: 776-781
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INVESTIGATIVE REPORT
Advanced Glycation End Products are Increased in the Skin and Blood of Patients with Severe Psoriasis
Anastasia Papagrigoraki, Micol Del Giglio, Chiara Cosma, Martina Maurelli, Giampiero Girolomoni, Annunziata Lapolla
Psoriasis is frequently associated with metabolic comorbidities. Advanced glycation end products (AGEs) are highly oxidant, biologically active compounds that accumulate in tissues in association with hyperglycaemia, hyperlipidaemia and oxidative stress. This is a cross-sectional case-control study involving 80 patients with mild/severe psoriasis and 80 controls matched for age, sex and body mass ...
Pages: 782-787
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INVESTIGATIVE REPORT
Involved and Uninvolved Psoriatic Keratinocytes Display a Resistance to Apoptosis that may Contribute to Epidermal Thickness
Cecilia Bivik Eding, Charlotta Enerbäck
Psoriasis is a common autoimmune skin disease. The aim of this study was to investigate whether the apoptotic process is disturbed in psoriatic keratinocytes. In vitro culture of keratinocytes derived from both involved and uninvolved psoriatic skin, revealed higher viability and resistance to apoptosis following exposure to ultraviolet B, compared with cells from healthy controls. The position of ...
Pages: 788-796
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INVESTIGATIVE REPORT
Expression of Filaggrin and its Degradation Products in Human Skin Following Erythemal Doses of Ultraviolet B Irradiation
Stine Simonsen, Jacob P. Thyssen, Steffen Heegaard, Sanja Kezic, Lone Skov
Epidermal filaggrin level is affected by ultraviolet B irradiation in animal and experimental models. This study examined the effect of ultraviolet B irradiation on epidermal filaggrin and natural moisturizing factors in vivo in healthy adults (n = 22). Participants were irradiated with 2 minimal erythema doses of ultraviolet B on the skin. Biopsies and tape strips were collected from ...
Pages: 797-801
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INVESTIGATIVE REPORT
Variation in Staphylococcus aureus Colonization in Relation to Disease Severity in Adults with Atopic Dermatitis during a Five-month Follow-up
Mikael Alsterholm, Louise Strömbeck, Annika Ljung, Nahid Karami, Johan Widjestam, Martin Gillstedt, Christina Åhren, Jan Faergemann
The aim of this study was to monitor Staphylococcus aureus colonization and disease severity in adults with atopic dermatitis (AD) during 5 months. Twenty-one patients attended 3 visits each for severity SCORing of Atopic Dermatitis (SCORAD) assessment, quantitative cultures from the skin and conventional cultures from the anterior nares, tonsils and perineum. S. aureus isolates were typed for str ...
Pages: 802-807
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INVESTIGATIVE REPORT
Incidence and Prevalence of Psoriasis in Denmark
Alexander Egeberg, Lone Skov, Gunnar H. Gislason, Jacob P. Thyssen, Lotus Mallbris
The incidence and temporal trends of psoriasis in Denmark between 2003 and 2012 were examined. There was a female predominance ranging between 50.0% (2007) and 55.4% (2009), and the mean age at time of diagnosis was 47.7–58.7 years. A total of 126,055 patients with psoriasis (prevalence 2.2%) were identified. Incidence rates of psoriasis (per 100,000 person years) ranged from 107.5 in 2005 to a ...
Pages: 808-812
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INVESTIGATIVE REPORT
Attachment Styles of Dermatological Patients in Europe: A Multi­centre Study in 13 Countries
Csanád Szabó, Anita Altmayer, Lars Lien, Françoise Poot, Uwe Gieler, Lucía Tomas-Aragones, Jörg Kupfer, Gregor B.E. Jemec, Laurent Misery, M. Dennis Linder, Francesca Sampogna, Henriët van Middendorp, Jon Anders Halvorsen, Flora Balieva, Jacek C. Szepietowski, Dmitry Romanov, Servando E. Marron, Ilknur K. Altunay, Andrew Y. Finlay, Sam S. Salek, Florence Dalgard
Attachment styles of dermatological outpatients and satisfaction with their dermatologists were investigated within the framework of a multicentre study conducted in 13 European countries, organized by the European Society for Dermatology and Psychiatry. Attachment style was assessed with the Adult Attachment Scale. Patient satisfaction with the dermatologist was assessed with an 11-degree scale. ...
Pages: 813-818
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CLINICAL REPORT
Risk of Myocardial Infarction in Patients with Psoriasis and Psoriatic Arthritis: A Nationwide Cohort Study
Alexander Egeberg, Jacob P. Thyssen, Peter Jensen, Gunnar H. Gislason, Lone Skov
Psoriasis has been associated with increased risk of myocardial infarction (MI) in some, but not all, studies. This study investigated the risk of MI in patients with psoriasis and psoriatic arthritis in Denmark. All residents aged ≥18 years from 1 January 2008 through 31 December 2012 were included. Adjusted hazard ratios (HRs) did not show an increased risk of MI in patients with mild psor ...
Pages: 819-824
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CLINICAL REPORT
Impact of High Age and Comorbidity on Management Decisions and Adherence to Guidelines in Patients with Keratinocyte Skin Cancer
Satish F.K. Lubeek, Celia A.J. Michielsens, Rinke J. Borgonjen, Ewald M. Bronkhorst, Peter C.M. van de Kerkhof, Marie-Jeanne P. Gerritsen
Appropriate medical decision-making in patients with keratinocyte skin cancer (KSC) can be challenging, especially in those with a limited life expectancy (LEx). Treatment should be beneficial for the individual patient, the risk of both over- and under-treatment should be carefully considered, and deviation from guideline recommendations may be necessary. In this study retrospective analysis was ...
Pages: 825-829
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CLINICAL REPORT
Shift in Occupational Risk for Basal Cell Carcinoma from Outdoor to Indoor Workers: A Large Population-based Case-control Register Study from Sweden
Bernt Lindelöf, Jan Lapins, Henrik Dal
Basal cell carcinoma (BCC) is the most common form of cancer worldwide. Exposure of the skin to ultraviolet (UV) radiation, from sunlight and other sources, is the most important risk factor. The aim of this large-scale case-control study was to determine which occupations are associated with increased risk of BCC in Sweden. The case cohort comprised 74,247 patients with BCC and the control cohort ...
Pages: 830-833
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CLINICAL REPORT
High Expression of Fas/CD95 on CD4+ Circulating T Cells: An Exclusion Criterion in the Diagnosis of Mycosis Fungoides?
Aurélie Du-Thanh, Pierre Portalès, Anne Serre-Cousiné, Céline Girard, Bernard Guillot, Olivier Dereure
The aim of this 10-year monocentric prospective study was to determine a cut-off value of Fas/CD95 expression by peripheral blood CD4+ T lymphocytes in discriminating patients with mycosis fungoides from controls with cutaneous benign lymphocytic conditions. CD95 expression in peripheral blood CD4+ T lymphocytes was measured using flow cytometry in 330 patients referred for diagnosis: 104 with myc ...
Pages: 834-837
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CLINICAL REPORT
Clinical Spectrum, Quality of Life, BRAF Mutation Status and Treatment of Skin Involvement in Adult Langerhans Cell Histiocytosis
Etienne Crickx, Jean-David Bouaziz, Gwenaël Lorillon, Mathilde de Menthon, Florence Cordoliani, Emmanuell Bugnet, Martine Bagot, Michel Rybojad, Samia Mourah, Abdellatif Tazi
Langerhans cell histiocytosis is a rare histiocytic disorder for which skin involvement and management are poorly described in adults. The aim of this retrospective monocentric study in a national reference centre is to describe the clinical characteristics, quality of life, BRAF mutation status and outcomes of skin involvement in adult patients with Langerhans cell histiocytosis. Twenty-five pati ...
Pages: 838-842
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CLINICAL REPORT
Efficacy of Botulinum Toxin B Injection for Raynaud’s Phenomenon and Digital Ulcers in Patients with Systemic Sclerosis
Sei-ichiro Motegi, Akihito Uehara, Kazuya Yamada, Akiko Sekiguchi, Chisako Fujiwara, Sayaka Toki, Yuki Date, Tetsuya Nakamura, Osamu Ishikawa
The efficacy and safety of botulinum toxin B (BTX-B) for treatment of Raynaud’s phenomenon and digital ulcers in patients with systemic sclerosis was assessed. A total of 45 patients with systemic sclerosis who had Raynaud’s phenomenon were blinded and divided randomly into 4 groups: a no-treatment control group, and 3 treatment groups, using 250, 1,000 or 2,000 international units (U) of BTX- ...
Pages: 843-850
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SHORT COMMUNICATION
Efficiency of an mTOR Inhibitor in Kasabach-Merritt Phenomenon with Indolent Tufted Angioma: A Case Report
Charlée Nardin, Olivia Boccara, Catherine Eschard, Michael Bayaram, Thibaud Dabudyk, François Aubin, Eve Puzenat
Abstract is missing (Short communication)
Pages: 851-852
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SHORT COMMUNICATION
Mosaic Focal Dermal Hypoplasia (Goltz Syndrome) in Two Female Patients
Maella Severino-Freire, Aude Maza, Maria Paola Lombardi, Emilie Tournier, Nicolas Chassaing, Juliette Mazereeuw-Hautier
Abstract is missing (Short communication)
Pages: 853-854
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SHORT COMMUNICATION
Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene
Pablo García-Martínez, Dolors Sitjas, Enric Llistosella, Blanca Espinet, María Rodríguez-Rivera, Maria Hernandez-Muñoz, Fernando Gallardo, Ramon M. Pujol
Abstract is missing (Short communication)
Pages: 855-857
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SHORT COMMUNICATION
Heterozygous PDGFRB Mutation in a Three-generation Family with Autosomal Dominant Infantile Myofibromatosis
Clemence Lepelletier, Yasser Al-Sarraj, Christine Bodemer, Hibbah Shaath , Sylvie Fraitag, Marios Kambouris , Dominique Hamel-Teillac, Hatem El Shanti, Smail Hadj-Rabia
Abstract is missing (Short communication)
Pages: 858-859
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SHORT COMMUNICATION
Onychomycosis Due to Arthrinium arundinis: A Case Report
Mariusz Dyląg, Anita Hryncewicz-Gwóźdź, Tomasz Jagielski
Abstract is missing (Short communication)
Pages: 860-861
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SHORT COMMUNICATION
Parent-of-origin Effect in Alopecia Areata: A Large-scale Pedigree Study
Silke Redler, F. Buket Ü. Basmanav, Bettina Blaumeiser, Natalie Garcia Bartels, Gerhard Lutz, Aylar Tafazzoli, Roland Kruse, Hans Wolff, Markus Böhm, Ulrike Blume-Peytavi, Tim Becker, Markus M. Nöthen, Regina C. Betz
Abstract is missing (Short communication)
Pages: 862-863
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CORRESPONDENCE
Digital Dermoscopy Monitoring: Is it Time to Define a Quality Standard?
Calogero Pagliarello, Ignazio Stanganelli, Giuseppe Fabrizi, Claudio Feliciani, Sergio Di Nuzzo
Abstract is missing (Correspondence)
Pages: 864-865
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QUIZ
Ulcerative Plaques and Nodules on the Lower Extremity: A Quiz
Amit Mittal, Antonio Subtil, Jonathan S. Leventhal
Abstract is missing (Quiz)
Pages: 866-867
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QUIZ
Is This Melanoma? A Quiz
Stefano Veraldi, Paolo Pontini, Francesco Sala, Diego Tosi
Abstract is missing (Quiz)
Pages: 868-869
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