Content

Content - Volume 98, Issue 4

Editor's choice in this issue

CLINICAL REPORT
Systemic Inflammation and Evidence of a Cardio-splenic Axis in Patients with Psoriasis
Kasper F. Hjuler, Lars C. Gormsen, Mikkel H. Vendelbo, Alexander Egeberg, Jakob Nielsen, Lars Iversen
This study demonstrates increased splenic inflammation in patients with psoriasis compared with age-matched control subjects. Given the well-established role of the spleen in systemic inflammatory diseases, this provides evidence of systemic inflammation in psoriasis beyond that reported by biomarker studies. Additionally, a significant association between splenic inflammation and aortic wall inflammation was found in psoriasis patients. Taken together, this study provides evidence supporting a spleen-atherosclerotic inflammatory axis in psoriasis.
Pages: 390-395
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INVESTIGATIVE REPORT
The Position of Targeted Next-generation Sequencing in Epidermolysis Bullosa Diagnosis
Cristina Has, Julia Küsel, Antonia Reimer, Julia Hoffmann, Franziska Schauer, Andreas Zimmer, Judith Fischer
• This study underscores the efficacy of the strategy combining targeted Next-generation Sequencing with immunofluorescence mapping (IFM) in resolving unusual epidermolysis bullosa phenotypes. It also suggests that, in spite of technological advances careful clinical evaluation and deep phenotyping remain crucial factors for successfully establishing epidermolysis bullosa diagnosis. IFM, an almost 40 year-old method delivers the correct classification of epidermolysis bullosa in more than 70% of the cases.
Pages: 437-440
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All articles

CLINICAL REPORT
Systemic Inflammation and Evidence of a Cardio-splenic Axis in Patients with Psoriasis
Kasper F. Hjuler, Lars C. Gormsen, Mikkel H. Vendelbo, Alexander Egeberg, Jakob Nielsen, Lars Iversen
The spleen is thought to play a role in atherosclerosis-associated immunity and cardiovascular research has indicated the existence of a cardio-splenic axis. The aim of this study was to assess splenic 18F-fluorodeoxyglucose uptake as a measure of systemic inflammation in patients with untreated psoriasis compared with historical controls assessed by positron emission tomography-computed tomograph ...
Pages: 390-395
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CLINICAL REPORT
Epidemiology and Medication Trends in Patients with Psoriasis: A Nationwide Population-based Cohort Study from Korea
Ju Hee Han, Ji Hyun Lee, Kyung Do Han, Hyun-Min Seo, Chul Hwan Bang, Young Min Park, Jun Young Lee, Yong Gyu Park
This study investigated the prevalence of psoriasis and trends in prescription of medications for patients with psoriasis using the Korean National Health Insurance Claims Database from 2006 to 2015. The prevalence of psoriasis and psoriatic arthritis per 10,000 people increased from 47.4 to 61.5 and from 0.04 to 0.23 respectively. The prescription of topical agents was a mean of 73.3%. For system ...
Pages: 396-400
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CLINICAL REPORT
Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China
Xiaojin Wu, Fanping Yang, Shengan Chen, Hao Xiong, Qinyuan Zhu, Xudong Gao, Qinghe Xing, Xiaoqun Luo
DRESS is one of the most severe drug reactions. The aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of DRESS. A total of 52 patients with DRESS, who were inpatients at a medical referral centre in Shanghai, China, from January 2011 to December 2016, were analysed retrospectively. All the patients had skin eruption, 83% had l ...
Pages: 401-405
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CLINICAL REPORT
Blood Predictive Biomarkers for Nivolumab in Advanced Melanoma
Edouard Chasseuil, Mélanie Saint-Jean, Hannah Chasseuil, Lucie Peuvrel, Gaëlle Quéreux, Jean-Michel Nguyen, Aurélie Gaultier, Emilie Varey, Amir Khammari, Brigitte Dréno
Nivolumab response rate is 40% in metastatic melanoma. Few studies have evaluated pre-treatment biomarkers predictive of response. The aim of this study was to identify potential peripheral blood biomarkers associated with survival in patients with advanced melanoma treated with nivolumab. All advanced melanoma cases treated with anti-programmed cell death protein 1 (anti-PD1) over a 3-year period ...
Pages: 406-410
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CLINICAL REPORT
Epidermolysis Bullosa (EB) Acquisita in an Adult Patient with Previously Unrecognized Mild Dystrophic EB and Biallelic COL7A1 Mutations
Liliana Guerra, Angelo Giuseppe Condorelli, Paola Fortugno, Valentina Calabresi, Cristina Pedicelli, Giovanni Di Zenzo, Daniele Castiglia
Circulating anti-type VII collagen autoantibodies are frequently detected in patients with recessive dystrophic epidermolysis bullosa (RDEB). However, evidence supporting their pathogenic role in inducing epidermolysis bullosa acquisita (EBA) has been provided for only one individual with dominant dystrophic epidermolysis bullosa (DDEB). We describe here a patient who presented with dystrophic toe ...
Pages: 411-415
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CLINICAL REPORT
Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients
Raúl Cabrera, Lia Hojman, Francisca Recule, Rodrigo Sepulveda, Iris Delgado
Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Many patients who were previously considered non-responders were given the opportunity to continu ...
Pages: 416-420
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INVESTIGATIVE REPORT
Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum
Tineke Berkers, Dani Visscher, Gert S. Gooris, Joke A. Bouwstra
Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less dense lateral lipid organization. In addition, parakeratosis was occasionally observed. The present study investigated whether the extent of initial bar ...
Pages: 421-427
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INVESTIGATIVE REPORT
Significant Changes in the Skin Microbiome in Patients with Chronic Plaque Psoriasis after Treatment with Narrowband Ultraviolet B
Malin Assarsson, Albert Duvetorp, Olaf Dienus, Jan Söderman, Oliver Seifert
Changes in the skin microbiome have been shown to promote cutaneous inflammation. The skin microbiome of patients with chronic plaque type psoriasis was analysed before and after treatment with narrowband ultraviolet B (UVB). Swab samples of the microbiome were taken from lesional and non-lesional skin of 26 patients. Microbiotas were characterized by sequencing 16S rRNA bacterial genes on the Ill ...
Pages: 428-436
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INVESTIGATIVE REPORT
The Position of Targeted Next-generation Sequencing in Epidermolysis Bullosa Diagnosis
Cristina Has, Julia Küsel, Antonia Reimer, Julia Hoffmann, Franziska Schauer, Andreas Zimmer, Judith Fischer
The precise classification of epidermolysis bullosa (EB) into 4 main types and more than 30 subtypes is based on the level of skin cleavage, as well as clinical and molecular features, and is crucial for early prognostication, case management, genetic counselling and prenatal or pre-implantation diagnosis. We report here the molecular pathology of 40 consecutive cases of suspected EB, which were i ...
Pages: 437-440
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INVESTIGATIVE REPORT
Delusional Infestation: Perspectives from Scottish Dermatologists and a 10-year Case Series from a Single Centre
Yee Ling Wong, Andrew Affleck, Alexander M. Stewart
Perceptions of the clinical management of delusional infestation (DI) were compared with clinical outcomes in this 10-year case series from a single centre in Dundee, UK. An online questionnaire (survey-monkey, a TM brand of online survey available for free for basic use) was sent to Scottish Dermatologists to gauge their opinions and confidence in the management of DI. Also, a retrospective revie ...
Pages: 441-445
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SHORT COMMUNICATION
Efficacy of Omalizumab Treatment with Concomitant Antihistamines as Needed for Moderate, Refractory Chronic Spontaneous Urticaria
Eustachio Nettis, Luca Cegolon, Luigi Macchia, Ippolita Zaza, Gianfranco Calogiuri, Elisabetta Di Leo
Abstract is missing (Short communication)
Pages: 446-448
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SHORT COMMUNICATION
Methotrexate Management in Psoriasis: Are We Following the Guidelines?
Tora Lindqvist, Louai A. Salah, Martin Gillstedt, Ann-Marie Wennberg, Amra Osmancevic
Abstract is missing (Short communication)
Pages: 449-451
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SHORT COMMUNICATION
Generalized Purpura as an Atypical Skin Manifestation of Adult-onset Still’s Disease in a Patient with Behçet’s Disease
Chika Omigawa, Takashi Hashimoto, Takaaki Hanafusa, Takeshi Namiki, Ken Igawa, Hiroo Yokozeki
Abstract is missing (Short communication)
Pages: 452-453
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SHORT COMMUNICATION
Ramucirumab-induced Multiple Haemangiomas of the Skin: Two Case Reports
Hideyuki Kosumi, Wataru Nishie, Tatsuro Sugai, Ellen Toyonaga, Norihiro Yoshimoto, Hiroyuki Nakamura, Ryota Horibe, Yasuo Kitamura, Hiroshi Nakatsumi, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 454-455
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SHORT COMMUNICATION
Eyelid Dermatitis as a Side Effect of Interleukin-17A Inhibitors in Psoriasis
Yuichi Teraki, Aya Takahashi, Yumiko Inoue, Saori Takamura
Abstract is missing (Short communication)
Pages: 456-457
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SHORT COMMUNICATION
Sarcoidal Foreign Body Reaction as a Severe Side-effect to Permanent Makeup: Successful Treatment with Intralesional Triamcinolone
Jörg Tittelbach, Melanie Peckruhn, Sibylle Schliemann, Peter Elsner
Abstract is missing (Short communication)
Pages: 458-459
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SHORT COMMUNICATION
Nodular Melanoma: A Histopathologic Entity?
Adèle C. Green, Amaya Viros, Maria Celia B. Hughes, Caroline Gaudy-Marqueste, Victoria Akhras, Martin G. Cook, Richard Marais
Abstract is missing (Short communication)
Pages: 460-462
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SHORT COMMUNICATION
Indeterminate Cell Histiocytosis Presenting with Leonine Facies
Cheng Chen, Giang Huong Nguyen, Yue-Ping Zeng
Abstract s missing (Short communication)
Pages: 463-464
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SHORT COMMUNICATION
Abatacept Improves Skin-score and Reduces Lesions in Patients with Localized Scleroderma: A Case Series
Simon Wehner Fage, Kristian Bakke Arvesen, Anne Braae Olesen
Abstract is missing (Short communication)
Pages: 465-466
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SHORT COMMUNICATION
Laser-assisted Photodynamic Therapy or Laser-assisted Amorolfine Lacquer Delivery for Treatment of Toenail Onychomycosis: An Open-label Comparative Study
Amir Koren, Fares Salameh, Eli Sprecher, Ofir Artzi
Abstract is missing (Short communication)
Pages: 467-468
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QUIZ
Rapidly Growing Nodule on the Finger of a 20-year-old Woman: A Quiz
Alexander Zink, Alicia Pichlmeier, Tatjana Fischer, Tilo Biedermann
Abstract is missing (Quiz)
Pages: 469-470
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QUIZ
A Longstanding Nodule on the Temple: A Quiz
Dominic Tabor, Stephanie Ball, Asok Biswas, Lisa Naysmith
Abstract is missing (Quiz)
Pages: 471-472
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IN THIS ISSUE
Banded Scalp Hair with an Unusual Glistening Appearance in a Teenager: A Quiz
Grigorios Theodosiou, Nils Hamnerius, Åke Svensson
Abstract is missing (Quiz)
Pages: 473-474
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QUIZ
Distinct Hyperkeratotic Lesions on Acral Skin and Lips: A Quiz
Youming Mei, Zhiming Chen, Wei Zhang, Jingshu Xiong, Hongsheng Wang
Abstract is missing (Quiz)
Pages: 475-476
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QUIZ
An Erythematous Papular Rash on the Left Flank of a 31-year-old Woman: A Quiz
Emily Rudd, Nicholas Francis, Luke Moore, Louise Fearfield
Abstract is missing (Quiz)
Pages: 477-478
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