Content

Content - Volume 99, Issue 4

Editor's choice in this issue

CLINICAL REPORT
Healthcare Service Utilization by 116,816 Patients with Atopic Dermatitis in Israel
Guy Shalom, Meir Babaev, Khalaf Kridin, Yochai Schonmann, Amir Horev, Jacob Dreiher, Michal Shani, Shmuel Tiosano, Shani Fisher, Doron Comaneshter, Arnon D. Cohen
Defining the epidemiology and healthcare service utilization in relation to atopic dermatitis is warranted to allow the incorporation of newly introduced treatments for atopic dermatitis. In a large group of 116,816 patients with atopic dermatitis, the disease was associated with an increased burden of healthcare utilization in a dose-response manner according to disease severity. These data quantifies healthcare utilization by patients with AD and can facilitate improved incorporation of innovative treatments into the healthcare system.
Pages: 370-374
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CLINICAL REPORT
Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis
Lina U. Ivert, Carl-Fredrik Wahlgren, Lena Ivert, Maria Lundqvist, Maria Bradley
This case series describes ten patients treated with dupilumab, where eye complications such as conjunctivitis were common, suggesting the importance of close collaboration with an ophthalmologist, especially among patients with severe, long-lasting AD and/or previous eye disease.
Pages: 375-378
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All articles

REVIEW
Skin Cancer Associated Genodermatoses: A Literature Review
Juliane Schierbeck, Tine Vestergaard, Anette Bygum
Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. The most ...
Pages: 360-369
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CLINICAL REPORT
Healthcare Service Utilization by 116,816 Patients with Atopic Dermatitis in Israel
Guy Shalom, Meir Babaev, Khalaf Kridin, Yochai Schonmann, Amir Horev, Jacob Dreiher, Michal Shani, Shmuel Tiosano, Shani Fisher, Doron Comaneshter, Arnon D. Cohen
Understanding of the epidemiology and healthcare service utilization related to atopic dermatitis is necessary to inform the use of new treatments. This cross-sectional study was based on a group of patients with atopic dermatitis and a matched control group comprised of age- and sex- matched enrolees without atopic dermatitis from a large medical database. Healthcare service utilization usage dat ...
Pages: 370-374
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CLINICAL REPORT
Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis
Lina U. Ivert, Carl-Fredrik Wahlgren, Lena Ivert, Maria Lundqvist, Maria Bradley
Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated with dupilumab where eye complications were very common. We have described patie ...
Pages: 375-378
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CLINICAL REPORT
Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU)
Athanasios Tsianakas, Claudia Zeidler, Claudia Riepe, Matthias Borowski, Caroline Forner, Joachim Gerss, Martin Metz, Petra Staubach, Ulrike Raap, Martin Kaatz, Marc Urban, Thomas A. Luger, Sonja Ständer
The aim of this multicentre, randomized, double-blind, placebo-controlled, cross-over, phase-II study was to determine the antipruritic effect of aprepitant vs. placebo in 58 patients with anti-histamine-refractory chronic pruritus in chronic nodular prurigo. Patients were randomized to receive either first oral aprepitant 80 mg/day or placebo for 4 weeks. Following a 2-week wash-out phase, the pa ...
Pages: 379-385
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CLINICAL REPORT
Beliefs About Medicines in Patients with Psoriasis Treated with Methotrexate or Biologics: A Cross-sectional Survey Study
Marisol E. Otero, Juul M.P.A. van den Reek, Peter C.M. van de Kerkhof, Jorre S. Mertens, Marieke M.B. Seyger, Wietske Kievit, Elke M.G.J. de Jong
Methotrexate (MTX) and biologics are frequently used treatments for psoriasis. Exploring patients’ beliefs about their treatment may help to elucidate patients’ attitudes towards these therapies. A cross-sectional survey was conducted using the Beliefs about Medicines Questionnaire-Specific (BMQ-Specific) in patients treated with methotrexate or biologics. BMQ-Specific scores (Necessity and Co ...
Pages: 386-392
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CLINICAL REPORT
A Cost-utility Analysis of Calcipotriol/Betamethasone Dipropionate Aerosol Foam versus Ointment for the Topical Treatment of Psoriasis Vulgaris in Sweden
Albert Duvetorp, Lars-Åke Levin, Emma Engerstedt Mattsson, Lasse Ryttig
Psoriasis is a chronic inflammatory disorder that imposes a substantial economic burden. We conducted a cost-utility analysis from a Swedish healthcare payers perspective using a decision-tree model with a 12-week time horizon. Patients with psoriasis vulgaris could have two 4-week cycles of topical treatment with calcipotriol 50 µg/g and betamethasone 0.5 mg/g as dipropionate (Cal/BD) foam or Ca ...
Pages: 393-399
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CLINICAL REPORT
Psoriasis Incidence and Lifetime Prevalence: Suggestion for a Higher Mortality Rate in Older Age-classes among Psoriatic Patients Compared to the General Population in Italy
Elena Pezzolo, Simone Cazzaniga, Paolo Colombo, Liliane Chatenoud, Luigi Naldi
Data on the psoriasis incidence and prevalence in the Italian population are limited, and a timely and accurate understanding of the disease epidemiology is needed. This ad hoc study investigated psoriasis incidence and lifetime prevalence in a representative sample (n = 14,705) of the Italian population. Information on lifetime history of skin disorders with details about their onset, duratio ...
Pages: 400-403
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CLINICAL REPORT
Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study
Lina Maria Serna-Higuita, Simone L. Harrison, Petra Buttner, Margaret Glasby, Beverly A. Raasch, Angelika Iftner, Claus Garbe, Peter Martus, Thomas Iftner
Keratinocyte cancer is the most common malignancy in Caucasians. The aim of this study was to investigate risk-factors responsible for development of keratinocyte cancer in Australia. A case-control study was conducted, including 112 cases of squamous cell carcinoma (SCC), 95 cases of basal cell carcinoma (BCC) and 122 controls. Freckling during adolescence (SCC: odds ratio (OR) 1.04, p < 0.01 ...
Pages: 404-411
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CLINICAL REPORT
Characteristics and Trends of Cutaneous Squamous Cell Carcinoma in a Patient Cohort in Finland 2006-2015
Niina Korhonen, Leea Ylitalo, Tiina Luukkaala, Julius Itkonen, Henni Häihälä, Juha Jernman, Erna Snellman, Johanna Palve
The incidence of cutaneous squamous cell carcinoma is increasing worldwide. In most epidemiological studies, only the first case of cutaneous squamous cell carcinoma is registered, underestimating the burden of the disease. To determine the frequency and detailed characteristics of cutaneous squamous cell carcinoma in a Finnish patient cohort, we performed a retrospective 10-year study taking into ...
Pages: 412-416
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CLINICAL REPORT
Patients with Moderate to Severe Psoriasis Associate with Higher Risk of Depression and Anxiety Symptoms: Results of a Multivariate Study of 300 Spanish Individuals with Psoriasis
Maria José Tribó, Marta Turroja, Gemma Castaño-Vinyals, Antonio Bulbena, Elena Ros, Pablo García-Martínez, Francisco Tausk, Marc Sagristà, Ramon M. Pujol, Marta Ferran, Fernando Gallardo
Psoriasis is a chronic skin disease associated with considerable physical and psychological comorbidities. Stress and emotional disturbances have been implicated in both triggering the onset and exacerbation of psoriasis. In order to determine the level of perceived stress and mood alterations in patients with psoriasis and their association with disease severity, 300 individuals completed diverse ...
Pages: 417-422
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INVESTIGATIVE REPORT
Mortality of Haemodialysis Patients With and Without Chronic Itch: A Follow-up Study of the German Epidemiological Hemodialysis Itch Study (GEHIS)
Katarzyna Grochulska, Robert F. Ofenloch, Thomas Mettang, Elke Weisshaar
The GEHIS (German Epidemiological Hemodialysis Itch Study) is a representative cohort study started in 2013 with 860 haemodialysis (HD) patients in 25 German dialysis units. Chronic itch (CI) has been reported to be a poor prognostic marker for patients on HD; however, this has not been investigated in a representative patient cohort. In 2017, all HD patients were contacted again to investigate mo ...
Pages: 423-428
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INVESTIGATIVE REPORT
Itch in Psoriasis: A New Look at Well-known Subject
Radomir Reszke, Rafał Białynicki-Birula, Jacek C. Szepietowski
Psoriasis is a chronic inflammatory dermatosis, frequently presenting with chronic itch. This study investigated the prevalence and detailed clinical characteristics of chronic itch in 143 psoriatic patients, with regard to different age groups, comorbidities and pharmacotherapy. Chronic itch was reported by 72% of subjects. Patients aged 65 years and over presented higher 4-Item Itch Questionnair ...
Pages: 429-434
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INVESTIGATIVE REPORT
Pruritus in Patients Under Targeted Anticancer Therapy: A Multidimensional Analysis Using the 5-D Itch Scale
Soo Ick Cho, Jaewon Lee, Jin Lim, Jong Seo Park, Miso Kim, Tae-Yong Kim, Tae Min Kim, Kyung-Hun Lee, Bhumsuk Keam, Sae-Won Han, Seong Jin Jo
Pruritus is a very common symptom in patients, undergoing targeted anticancer therapy. However, the characteristics of pruritus, according to the targeted anticancer agents, are still unclear. The objective of this study was to determine the characteristics of pruritus, induced by targeted anticancer agents, using a questionnaire-based survey. The survey was administered to cancer patients current ...
Pages: 435-441
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SHORT COMMUNICATION
Plasma Dynorphin A Concentration Reflects the Degree of Pruritus in Chronic Liver Disease: A Preliminary Report
Catharina Sagita Moniaga, Shiho Iwamoto, Tsuneo Kitamura, Maki Fujishiro , Nobuaki Takahashi, Katsunari Kina, Hideoki Ogawa, Mitsutoshi Tominaga, Kenji Takamori
Abstract is missing (Short communication)
Pages: 442-443
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SHORT COMMUNICATION
Polymorphisms in Corticotrophin-releasing Hormone-proopiomelanocortin (CRH-POMC) System Genes are Associated with Plaque Psoriasis
Tanel Traks, Maris Keermann, Maire Karelson, Ranno Rätsep, Ene Reimann, Helgi Silm, Eero Vasar, Sulev Kõks, Külli Kingo
Abstract is missing (Short communication)
Pages: 444-445
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SHORT COMMUNICATION
A Case of Ixekizumab-induced Psoriasiform Eruption
Tomohiro Oiwa, Mafumi Fujita, Sawako Takase, Youichi Nishimura, Miyuki Ota, Kayo Okada, Takao Tachibana
Abstract is missing (Short communication)
Pages: 446-447
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SHORT COMMUNICATION
Combining Omalizumab with Another Biotherapy
Anne-Claire Fougerousse, Pierre-André Becherel, Valérie Pallure, Thierry Boyé, Ziad Reguiai, Germaine Gabison, Hughes Barthelemy, Antoine Badaoui, Emmanuel Mahé, Cristina Bulai Livideanu; for the GEM ResoPso
Abstract is missing (Short communication)
Pages: 448-449
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SHORT COMMUNICATION
Disfiguring Nodular Cephalic Xanthoma Disseminatum: An Exceptional Variant of a Forgotten Entity
Arturo Bonometti, Jessica Gliozzo, Chiara Moltrasio, Filippo Bagnoli, Luigia Venegoni, Emanuela Passoni, Marco Paulli, Emilio Berti
Abstract is missing (Short communication)
Pages: 450-451
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SHORT COMMUNICATION
Massive Localized Lymphedema, an Emerging Problem and a Challenging Pseudosarcomatous Condition Mimicking Liposarcoma
Aleksandra G. Florek, Rami Lutfi, Kenneth Wind, Wenhua Liu, Aleksandar L. Krunic
Abstract is missing (Short communication)
Pages: 452-453
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SHORT COMMUNICATION
Effect of Topical Rapamycin 1% on Multiple Trichoepitheliomas
Isabelle Dreyfus, Giuliana Onnis, Emilie Tournier, Olivier Dereure, Juliette Mazereeuw-Hautier
Abstract is missing (Short communication)
Pages: 454-455
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SHORT COMMUNICATION
Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report
Chunli Yang, Sha Zhao, Lin Wang, Linqun Zou
Abstract is missing (Short communication)
Pages: 456-457
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SHORT COMMUNICATION
A Japanese Case of Galli-Galli Disease due to a Previously Unreported POGLUT1 Mutation
Michihiro Kono, Masaki Sawada, Yuka Nakazawa, Tomoo Ogi, Yoshinao Muro, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 458-459
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SHORT COMMUNICATION
A Silent COL17A1 Variant Alters Splicing and Causes Junctional Epidermolysis Bullosa
Julia Hoffmann, Federica Casetti, Antonia Reimer, Juna Leppert, Gabriele Grüninger, Cristina Has
Abstract is missing (Short communication)
Pages: 460-461
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SHORT COMMUNICATION
High-risk Mucosal Human Papillomavirus Infection in Squamous Cell Carcinoma and Bowen's Disease of the Hand
Sonja Dorfer, Stefanie Kancz, Peter Birner, Katharina Strasser, Reinhard Kirnbauer, Peter Petzelbauer, Sonja Radakovic, Lucie Harpain, Hubert Pehamberger, Florian Thalhammer, Alessandra Handisurya
Abstract is missing (Short communication)
Pages: 462-463
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SHORT COMMUNICATION
Severe Septic Vasculitis Preceding Thoracic Empyema: Staphylococcus aureus Enterotoxin Deposition in Vessel Walls as a Possible Pathomechanism
Yasuyuki Yamaguchi, Yasuyuki Fujita, Tetsuya Ikeda, Yosuke Mai, Hajime Miyazawa, Wakana Matsumura, Toshifumi Nomura, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 464-465
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QUIZ
An Asymptomatic Verrucous Nodule on the Scrotum: A Quiz
Yue-Tong Qian, Jia-Wei Liu, Wei Liu, Dong-Lai Ma
Abstract is missing (Quiz)
Pages: 466-467
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BOOK REVIEW
Facial Reconstruction after Mohs Surgery
John Paoli
Abstract is missing (Book review)
Page: 468
Abstract  PDF