Content

Content - Volume 97, Issue 2

Editor's choice in this issue

SPECIAL REPORT
A Review of International Recommendations for the Diagnosis and Management of Chronic Urticaria
Lisa A. Beck, Jonathan A. Bernstein, Marcus Maurer
Both spontaneous and inducible forms of chronic urticaria pose a significant economic burden and have an adverse effect on patients’ quality of life. The international guidelines and US practice parameters for the diagnosis and management of chronic urticaria both recommend performing a thorough patient history and physical examination, conducting limited routine laboratory testing, and taking a ...
Pages: 149-158
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INVESTIGATIVE REPORT
Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa
Hans Christian Ring, Lene Bay, Klaus Kallenbach, Iben M. Miller, Errol Prens, Ditte M. Saunte, Thomas Bjarnsholt, Gregor B.E. Jemec
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginous regions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesized that clinically unaffected HS skin would also have an increased presence of bi ...
Pages: 208-213
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All articles

SPECIAL REPORT
A Review of International Recommendations for the Diagnosis and Management of Chronic Urticaria
Lisa A. Beck, Jonathan A. Bernstein, Marcus Maurer
Both spontaneous and inducible forms of chronic urticaria pose a significant economic burden and have an adverse effect on patients’ quality of life. The international guidelines and US practice parameters for the diagnosis and management of chronic urticaria both recommend performing a thorough patient history and physical examination, conducting limited routine laboratory testing, and taking a ...
Pages: 149-158
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SPECIAL REPORT
Self-Inflicted Lesions in Dermatology: A Management and Therapeutic Approach – A Position Paper From the European Society for Derma­tology and Psychiatry
Lucía Tomas-Aragones, Silla M. Consoli, Sylvie G. Consoli, Francoise Poot, Klaus-Michael Taube, M. Dennis Linder, Gregor B.E. Jemec, Jacek C. Szepietowski, John de Korte, Andrey N. Lvov, Uwe Gieler
The classification of self-inflicted skin lesions proposed by the European Society for Dermatology and Psychiatry (ESDaP) group generated questions with regard to specific treatments that could be recommended for such cases. The therapeutic guidelines in the current paper integrate new psychotherapies and psychotropic drugs without forgetting the most important relational characteristics required ...
Pages: 159-172
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SPECIAL REPORT
Apoptosis May Explain the Pharmacological Mode of Action and Adverse Effects of Isotretinoin, Including Teratogenicity
Bodo C. Melnik
Isotretinoin (13-cis retinoic acid) is the most effective sebum-suppressive drug for the treatment of severe acne. Its effect depends on sebocyte apoptosis, which results from isotretinoin-induced expression of the apoptotic protein tumour necrosis factor-related apoptosis-inducing ligand, insulin-like growth factor-binding protein-3 and neutrophil gelatinase-associated lipocalin. This review prop ...
Pages: 173-181
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INVESTIGATIVE REPORT
Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Csilla Korponyai, Edit Szél, Zoltán Behány, Erika Varga, Gábor Mohos, Ágnes Dura, Shabtay Dikstein, Lajos Kemény, Gábor Erős
Glycerol and xylitol hydrate the skin and improve its barrier function over a short period. We studied the effects of glycerol and xylitol on the physiological properties and morphology of the skin after longer-term application. Twelve volunteers with dry skin were examined. Three areas on the arms were determined. Area 1 served as untreated control. The vehicle was applied to area 2, while area 3 ...
Pages: 182-187
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INVESTIGATIVE REPORT
Water Exposure on the Hands in Adolescents: A Report from the BAMSE Cohort
Birgitta Meding, Carina M. Grönhagen, Anna Bergström, Inger Kull, Karin Wrangsjö, Carola Lidén
Water exposure on the skin of the hands has previously been studied in adults. The aim of this study was to investigate self-reported water exposure in adolescents in the BAMSE cohort in Stockholm, Sweden. A questionnaire including a question on daily water exposure on the hands was answered by 3,091 adolescents at age 16 years. Exposure > 10 times/day was reported by 28.7% and > 20 ti ...
Pages: 188-192
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INVESTIGATIVE REPORT
Scoring of Hand Eczema: Good Reliability of Hand Eczema Extent Score (HEES)
Annica Carlsson, Åke Svensson, Chris D. Anderson, Irina Baranovskaya, Monica Hindsén-Stenström, Ingebjörg Holt, Birgitta Meding, Berndt Stenberg, Hans Stenlund, Agneta Gånemo
There is good agreement between dermatological staff and patients using the Hand Eczema Extent Score (HEES). The aim of this study was to assess inter- and intra-observer reliability of the HEES in dermatologists and intra-observer reliability of the HEES in patients with hand eczema. Six dermatologists assessed 18 patients twice. Only the hands of the patients were visible to the assessors. Patie ...
Pages: 193-197
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INVESTIGATIVE REPORT
A Test–Retest Reliability Study of Human Experimental Models of Histaminergic and Non-histaminergic Itch
Hjalte H. Andersen, Anne-Kathrine R. Sørensen, Gebbie A.R. Nielsen, Marianne S. Mølgaard, Pernille Stilling, Shellie A. Boudreau, Jesper Elberling, Lars Arendt-Nielsen
Numerous exploratory, proof-of-concept and interventional studies have used histaminergic and non-histaminergic human models of itch. However, no reliability studies for such surrogate models have been conducted. This study investigated the test–retest reliability for the response to histamine- and cowhage- (5, 15, 25 spiculae) induced itch in healthy volunteers. Cowhage spiculae were individual ...
Pages: 198-207
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INVESTIGATIVE REPORT
Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa
Hans Christian Ring, Lene Bay, Klaus Kallenbach, Iben M. Miller, Errol Prens, Ditte M. Saunte, Thomas Bjarnsholt, Gregor B.E. Jemec
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginous regions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesized that clinically unaffected HS skin would also have an increased presence of bi ...
Pages: 208-213
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INVESTIGATIVE REPORT
Alterations in Factors Involved in Differentiation and Barrier Function in the Epithelium in Oral and Genital Lichen Planus
Karin Danielsson, Majid Ebrahimi, Elisabet Nylander, Ylva Britt Wahlin, Karin Nylander
Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding ...
Pages: 214-218
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INVESTIGATIVE REPORT
Association of Multiple Melanocytic Naevi with Education, Sex and Skin Type. A Northern Finland Birth Cohort 1966 Study with 46 Years Follow-up
Suvi-Päivikki Sinikumpu, Laura Huilaja, Jari Jokelainen, Juha Auvinen, Markku Timonen, Kaisa Tasanen
Having multiple melanocytic naevi (> 50 naevi) is one of the strongest risk factors for melanoma. However, the epidemiology in adults is unclear. This comprehensive dermatological status investigation of 1,932 birth-cohort study cases aged 46 years analysed the prevalence of multiple melanocytic naevi and their association with sex, socioeconomic status (education) in childhood and adulthood ...
Pages: 219-224
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CLINICAL REPORT
Burden of Keloid Disease: A Cross-sectional Health-related Quality of Life Assessment
Eveline Bijlard, Casimir A. E. Kouwenberg, Reinier Timman, Steven E.R. Hovius, Jan J. V. Busschbach, Marc A.M. Mureau
Keloid scars may be painful, itch severely and be cosmetically disturbing. The burden of keloid disease, however, has not yet been determined. This study evaluated the association of keloid disease with health-related quality of life (HRQL) and identified indicators of burden using a cross-sectional survey study, with one disease-specific HRQL measure (Skindex-29) and 2 generic HRQL measures (SF-3 ...
Pages: 225-229
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CLINICAL REPORT
Dynamic Pruritus Score: Evaluation of the Validity and Reliability of a New Instrument to Assess the Course of Pruritus
Sonja Ständer, Christine Blome, Zografia Anastasiadou, Claudia Zeidler, Katharina Anna Jung, Athanasios Tsianakas, Gitta Neufang, Matthias Augustin
Currently valid itch intensity scales, such as the visual analogue scale (VAS), are indispensable, but they can be influenced by the patient’s overall health status. The aim of this study was to evaluate the reliability and validity of the Dynamic Pruritus Score (DPS), a new instrument comparing reduction in current pruritus with a defined earlier time-point. Eighty-one randomly selected adults ...
Pages: 230-234
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CLINICAL REPORT
Podoplanin Expression Correlates with Disease Progression in Mycosis Fungoides
Alina Jankowska-Konsur, Christopher Kobierzycki, Jędrzej Grzegrzółka, Aleksandra Piotrowska, Agnieszka Gomulkiewicz, Natalia Glatzel-Plucinska, Adam Reich, Marzenna Podhorska-Okołów, Piotr Dzięgiel, Jacek C. Szepietowski
The aim of this study was to investigate the role of lymphangiogenesis in the clinical progression and outcome of mycosis fungoides. Immunohistochemistry and Western blot techniques were used to assess the expression of podoplanin and vascular endothelial growth factor C in mycosis fungoides. Expression of vascular endothelial growth factor C measured by immunohistochemistry was significantly high ...
Pages: 235-241
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CLINICAL REPORT
Two Consecutive Standardized Skin Surface Biopsies: An Improved Sampling Method to Evaluate Demodex Density as a Diagnostic Tool for Rosacea and Demodicosis
Fabienne M.N. Forton, Viviane De Maertelaer
Diagnosing papulopustular rosacea is not always straightforward; no specific diagnostic test is currently available. A high density of Demodex mites is consistently observed in this condition. This retrospective study assesses an improved method for evaluating Demodex density among 1,044 patients presenting to our dermatology practice. The skin was cleaned with ether and Demodex densities were mea ...
Pages: 242-248
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CLINICAL REPORT
Acquired Reactive Perforating Dermatosis is a Variant of Prurigo Nodularis
Roxane-Isabelle Kestner, Sonja Ständer, Nani Osada, Dan Ziegler, Dieter Metze
Patients with chronic pruritus may develop scratch-induced lesions with elevated borders and central necrosis. This so-called umbilicated type of prurigo (UP) is rare and is assumed to develop preferentially in the context of metabolic diseases. The aim of this study was to characterize UP in its clinical and histological dimension. Demographic and clinical data were collected from 23 patients wit ...
Pages: 249-254
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SHORT COMMUNICATION
Empowering Heliotherapy in Psoriasis and Atopic Dermatitis: An Observational Study of 186 Subjects
Toni Karppinen, Juha-Pekka Laine, Hannu Kautiainen, Rafael Pasternack, Timo Reunala, Erna Snellman
Abstract is missing (Short communication)
Pages: 255-257
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SHORT COMMUNICATION
Development of Cutaneous Toxicities During Selective Anti-BRAF Therapies: Preventive Role of Combination with MEK Inhibitors
Gamze Erfan, Susana Puig, Cristina Carrera, Ana Arance, Lydia Gaba, Ivan Victoria, Adriana Garcia-Herrera, Llucia Alos, Josep Malvehy
Abstract is missing (Short communication)
Pages: 258-260
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SHORT COMMUNICATION
Cardiovascular Risk is not Increased in Patients with Chronic Urticaria: A Retrospective Population-based Cohort Study
Alexander Egeberg, Kristian Kofoed, Gunnar H. Gislason, Christian Vestergaard, Jacob P. Thyssen
Abstract is missing (Short communication)
Pages: 261-262
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SHORT COMMUNICATION
Effect of a Dermoscopy Training Course on the Accuracy of Primary Care Physicians in Diagnosing Pigmented Lesions
Lisanne J. Secker, Pieter A.J. Buis, Wilma Bergman, Nicole A. Kukutsch
Abstract is missing (Short communication)
Pages: 263-265
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SHORT COMMUNICATION
Sex Differences in Axial and Limb Distribution of Melanocytic Naevi
Calogero Pagliarello, Ignazio Stanganelli, Fabio Zambito-Spadaro, Claudio Feliciani, Sergio Di Nuzzo
Abstract is missing (Short communication)
Pages: 266-267
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SHORT COMMUNICATION
Primary Eccrine Adenocarcinoma of the Skin: A Single-centre Experience of 10 Years
Jimyung Seo, Yeongjoo Oh, Jun Young Kim, Kyoung Ae Nam, Kee Yang Chung
Abstract is missing (Short communication)
Pages: 268-269
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SHORT COMMUNICATION
Correlations Between Disease-specific DLQI and Generic WHOQOL-BREF Quality of Life Instruments in a Clinical Population with Mixed Dermatological Diagnoses: A Pilot Study
Karolina Evenhamre, Maria Palmetun Ekbäck, Magnus Lindberg
Abstract is missing (Short communication)
Pages: 270-272
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SHORT COMMUNICATION
Epstein-Barr Virus-associated Natural Killer/T-cell Lymphoma in a Patient Receiving Therapy with Anti-Tumour Necrosis Factor and Thiopurine
Chiaki Murase, Yasushi Ogawa, Azusa Yamamoto, Chisako Iriyama, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 273-274
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SHORT COMMUNICATION
Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome Treated with Granulocyte and Monocyte Adsorption Apheresis
Yoko Mizutani, Tomomi Okano, Tomoko Takahashi, Hidenori Ohnishi, Osamu Ohara, Akiyo Sano, Mariko Seishima
Abstract is missing (Short communication)
Pages: 275-276
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SHORT COMMUNICATION
Recurrent Cellulitis Caused by Helicobacter cinaedi in a Patient with X-linked Agammaglobulinaemia
Masayo Sugimoto, Takuya Takeichi, Hideki Muramatsu, Daiei Kojima, Yukari Osada, Michihiro Kono, Seiji Kojima, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 277-278
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SHORT COMMUNICATION
Imiquimod-induced Psoriatic Erythroderma Treated with Infliximab
Reiko Tsutsumi, Yuichi Yoshida, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 279-280
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SHORT COMMUNICATION
A Case of Angioinvasive Cutaneous Anaplastic Large Cell Lymphoma Completely Regressed After Low-dose Systemic Methotrexate
Anna Ferrazzi, Irene Russo, Emanuele S.G. D'Amore, Mauro Alaibac
Abstract is missing (Short communication)
Pages: 281-282
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SHORT COMMUNICATION
Successful Treatment of Refractory Alopecia Areata Universalis and Psoriatic Arthritis, But Not of Plaque Psoriasis with Tofacitinib in a Young Woman
Ulrich Mrowietz, Sascha Gerdes, Regine Gläser, Oltmann Schröder
Abstract is missing (Short communication)
Pages: 283-284
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SHORT COMMUNICATION
A Female with Hereditary Angioedema Developing Wheals: A Case Report
Marloes S. van Kester, Wilma Bergman, Adriana P.M. Lavrijsen
Abstract is missing (Short communication)
Pages: 285-286
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SHORT COMMUNICATION
Melanotic Malignant Melanoma in Oculocutaneous Albinism Type 4
Saeko Ozaki, Yoko Funasaka, Yohei Otsuka, Satomi Oyama, Michiko Ito, Shin-ichi Osada, Takashi Ueno, Ken Okamura, Yutaka Hozumi, Tamio Suzuki, Seiji Kawana, Hidehisa Saeki
Abstract is missing (Short communication)
Pages: 287-288
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SHORT COMMUNICATION
Co-existence of Intravascular Papillary Endothelial Hyperplasia in Superficial Skin and the Intermuscular Space
Yuri Asami, Yasuhiro Nakamura, Yukiko Teramoto, Sayuri Sato, Taichi Imamura, Akifumi Yamamoto
Abstract is missing (Short communication)
Pages: 289-290
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SHORT COMMUNICATION
Widespread Molluscum Contagiosum with Atopic Dermatitis-like Skin Manifestations
Sakiko Chikazawa, Sayaka Takai, Aiko Furuya, Tamaki Kato, Osamu Ohara, Takashi Hashimoto, Shigeaki Nonoyama, Takahiro Satoh
Abstract is missing (Short communication)
Pages: 291-292
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SHORT COMMUNICATION
Blastic Plasmacytoid Dendritic Cell Neoplasm Associated with Dystrophic Xanthomatosis after Chemotherapy
Lidia García-Colmenero, Fernando Gallardo, Antonio Salar, Alberto Alvarez-Larrán, Lluís Colomo, Ramon M. Pujol
Abstract is missing (Short communication)
Pages: 293-294
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SHORT COMMUNICATION
Alopecia Induced by Timolol Eye-drops
Ken Muramatsu, Toshifumi Nomura, Chihiro Shiiya, Keiko Nishiura, Ichiro Tsukinaga
Abstract is missing (Short communication)
Pages: 295-296
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SHORT COMMUNICATION
Keloids, Spontaneous or After Minor Skin Injury: Importance of Not Missing Bethlem Myopathy
Constanza Echeverría, Alejandra Diaz, Bernardita Suarez, Jorge A. Bevilacqua, Carsten Bonnemann, Enrico Bertini, Claudia Castiglioni
Abstract is missing (Short communication)
Pages: 297-298
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QUIZ
Multilocular Facial Necrosis in a Young Boy: A Quiz
Barbara Miernik, Federica Casetti, Marcus Panning, Daniela Huzly, Hermann Meyer, Kristin Technau-Hafsi
Abstract is missing (Quiz)
Pages: 299-301
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