Content

Content - Volume 98, Issue 2

Editor's choice in this issue

INVESTIGATIVE REPORT
Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back
Marie-Ange Dagnelie, Stéphane Corvec, Mélanie Saint-Jean, Valérie Bourdès, Jean-Michel Nguyen, Amir Khammari, Brigitte Dréno
This study presents Cutibacterium acnes (formerly Propionibacterium acnes) subgroups distribution on the back and face of severe acne patients versus healthy controls. It notably shows a drastic reduction of the phylotype diversity on the back of acne group comparing with healthy controls. These data suggest the possibility to set up innovative acne therapies such as probiotic-based systems in order to restore the phylotype diversity associated with healthy skin.
Pages: 262-267
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INVESTIGATIVE REPORT
Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy
Michael Brandwein, Garold Fuks, Avigail Israel, Ashraf Al-Ashhab, Deborah Nejman, Ravid Straussman, Emmilia Hodak, Marco Harari, Doron Steinberg, Zvi Bentwich, Noam Shental, Shiri Meshner
Dead Sea climatotherapy (DSC) is a therapeutic modality for a variety of chronic skin conditions including psoriasis, vitiligo and atopic dermatitis. Previous studies have documented microbiome changes following therapeutic regimens for the aforementioned diseases. In the article entitled "Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy," the authors describe changes to the healthy skin fungal and bacterial microbiome following Dead Sea climatotherapy. Their research sheds light on the temporal dynamics of the skin microbiome using this therapeutic regimen and is important in the understanding of its mechanisms.
Pages: 256-261
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All articles

REVIEW
Chronic Prurigo of Nodular Type: A Review
Claudia Zeidler, Athanasios Tsianakas, Manuel Pereira, Hartmut Ständer, Gil Yosipovitch, Sonja Ständer
Prurigo nodularis (PN) is a subtype of chronic prurigo presenting single to multiple symmetrically distributed, hyperkeratotic and intensively itching papules and nodules. PN evolves along with chronic pruritus in the context of diverse dermatological, systemic, neurological or psychiatric conditions. Permanent scratching is possibly a major trigger of PN, although its exact pathophysiology remain ...
Pages: 173-179
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REVIEW
Fractional Carbon Dioxide Laser as an "Add-on" Treatment for Vitiligo: A Meta-analysis with Systematic Review
Hyun Jung Kim, Eun Sun Hong, Sang Hyun Cho, Jeong Deuk Lee, Hei Sung Kim
Treatment of vitiligo is challenging and requires a multidisciplinary approach. Fractional carbon dioxide (CO2) laser as an add-on to conventional treatment has been reported to be effective, but there is no consensus on its use. A systematic review was performed by searching major databases for relevant publications to February 2017. Six studies with 85 participants were included. For those with ...
Pages: 180-184
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CLINICAL REPORT
Burden of Aquagenic Pruritus in Polycythaemia Vera
Edyta Lelonek, Łukasz Matusiak, Tomasz Wróbel, Jacek Kwiatkowski, Jacek C. Szepietowski
Aquagenic pruritus (AP) has a significant influence on quality of life (QoL) in patients with polycythaemia vera. This study analysed the impact of AP on patient well-being in 102 patients with polycythaemia vera. Intensity of pruritus was evaluated using a visual analogue scale (VAS), verbal rating scale (VRS) and a 4-item Itch Questionnaire. Psychosocial aspects of AP were assessed with the Hosp ...
Pages: 185-190
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CLINICAL REPORT
Clinical Characteristics of Pruritus and Pain in Patients with Hidradenitis Suppurativa
Łukasz Matusiak, Justyna Szczęch, Karolina Kaaz, Edyta Lelonek, Jacek C. Szepietowski
A growing body of research has indicated that pruritus is an important feature of hidradenitis suppurativa (HS). This study evaluated pruritus and pain among 103 patients with HS. Pruritus and pain intensity were assessed with a visual analogue scale, numerical rating scale and 4-item Itch Questionnaire. Dermatology Life Quality Index (DLQI) was implemented to assess quality of life (QoL) issues. ...
Pages: 191-194
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CLINICAL REPORT
Diagnostic Delay in Dermatitis Herpetiformis in a High-prevalence Area
Eriika Mansikka, Teea Salmi, Katri Kaukinen, Pekka Collin, Heini Huhtala, Timo Reunala, Kaisa Hervonen
Dermatitis herpetiformis (DH) is an extra-intestinal manifestation of coeliac disease. The highest currently reported prevalence of DH is in Finland, but knowledge of diagnostic delay is limited. This study investigated the duration of rash prior to diagnosis in 446 patients with DH, analysing the results in 3 periods of 15 years. The diagnosis was considered delayed when the duration of rash befo ...
Pages: 195-199
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CLINICAL REPORT
Patients’ and Physicians’ Preferences for Systemic Psoriasis Treatments: A Nationwide Comparative Discrete Choice Experiment (PsoCompare)
Marthe-Lisa Schaarschmidt, Raphael Herr, Mandy Gutknecht, Katharina Wroblewska, Sascha Gerdes, Michael Sticherling, Matthias Augustin, Wiebke K. Peitsch
Systemic antipsoriatic treatment options are increasing rapidly. The aim of this nationwide discrete choice experiment was to compare patients’ (n = 222) and physicians’ (n = 78) preferences for outcome and process attributes of systemic antipsoriatics using Relative Importance Scores (RIS). Both groups considered Psoriasis Area and Severity Index 90 (PASI 90) to be most important (RIS ...
Pages: 200-205
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CLINICAL REPORT
Cutaneous Chronic Graft Versus Host Disease Following Allogeneic Haematopoietic Stem Cell Transplantation in Children: A Retrospective Study
Rony Shreberk-Hassidim, Michal Neumark, Shoshana Greenberger, Gal Goldstein, Ayal Hassidim, Yuval Dukler, Alexander Maly, Polina Stepensky, Vered Molho-Pessach
Chronic graft versus host disease (cGVHD) is a complication of allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to clinically characterize childhood cutaneous cGVHD. A retrospective study of children treated with HSCT at 2 tertiary medical centres in Israel between 2011 and 2014 was performed. A total of 112 children were included. Cutaneous cGVHD developed in ...
Pages: 206-211
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CLINICAL REPORT
Nail Involvement in Alopecia Areata: A Questionnaire-based Survey on Clinical Signs, Impact on Quality of Life and Review of the Literature
Yvonne B.M. Roest, Henriët van Middendorp, Andrea W.M. Evers, Peter C.M. van de Kerkhof, Marcel C. Pasch
Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes in patients with AA. This questionnaire-based survey evaluated 256 patients with AA. General demographic variables, specific nail changes, nail-rel ...
Pages: 212-217
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CLINICAL REPORT
Estimation of Direct Melanoma-related Costs by Disease Stage and by Phase of Diagnosis and Treatment According to Clinical Guidelines
Alessandra Buja, Gino Sartor, Manuela Scioni, Antonella Vecchiato, Mario Bolzan, Vincenzo Rebba, Vanna Chiarion Sileni, Angelo Claudio Palozzo, Maria Montesco, Paolo Del Fiore, Vincenzo Baldo, Carlo Riccardo Rossi
Cutaneous melanoma is a major concern in terms of healthcare systems and economics. The aim of this study was to estimate the direct costs of melanoma by disease stage, phase of diagnosis, and treatment according to the pre-set clinical guidelines drafted by the AIOM (Italian Medical Oncological Association). Based on the AIOM guidelines for malignant cutaneous melanoma, a highly detailed decision ...
Pages: 218-224
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CLINICAL REPORT
Tailored Therapist-guided Internet-based Cognitive-behavioural Treatment for Psoriasis and Rheumatoid Arthritis: Two Case Reports
Saskia Spillekom-van Koulil, Maaike Ferwerda, Sylvia van Beugen, Henriët van Middendorp, Peter C.M. van de Kerkhof, Piet L.C.M. van Riel, Andrea W.M. Evers
Chronic somatic conditions, such as psoriasis, arthritis psoriatica and rheumatoid arthritis, have a large impact on patients’ lives. Tailored therapist-guided internet-based cognitive-behavioural therapy (ICBT) has been shown to be effective in improving physical and psychological well-being in these patients. Two cases are presented here, in order to provide an in-depth illustration of the cou ...
Pages: 225-233
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CLINICAL REPORT
Development and Validation of the Basal and Squamous Cell Carcinoma Quality of Life (BaSQoL) Questionnaire
Rick Waalboer-Spuij, Loes M. Hollestein, Reinier Timman, Lonneke V. van de Poll-Franse, Tamar E. Nijsten
Health-related quality of life (HRQoL) is important in the management of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Disease-specific questionnaires exist, but with important shortcomings. The aim of this study was to develop and validate a questionnaire suitable for use in all patients with BCC and those with SCC. In a 4-phase trajectory, a preliminary questionnaire was created ...
Pages: 234-239
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CLINICAL REPORT
Patients' Illness Perception as a Tool to Improve Individual Disease Management in Primary Cutaneous Lymphomas
Stefanie Porkert, Eva Lehner-Baumgartner, Julia Valencak, Robert Knobler, Elisabeth Riedl, Constanze Jonak
The Revised Illness Perception Questionnaire (IPQ-R) has been shown to assess illness perception reproducibly in primary cutaneous T-cell lymphomas (CTCL). Illness perception reflects patients' individual concepts of understanding and interpretation of the disease, influencing illness behaviour and health-related quality of life (HRQOL). This study investigated the clinical relevance of the relati ...
Pages: 240-245
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INVESTIGATIVE REPORT
Risk Factors for Surgical Site Infections in Dermatological Surgery
Xiaomeng Liu, Melissa Sprengers, Patty J. Nelemans, Klara Mosterd, Nicole W.J. Kelleners-Smeets
Current literature on risk factors for surgical site infection (SSI) in dermatological surgery in the absence of antibiotic prophylaxis is limited. The aim of this study was to retrospectively evaluate patients presenting for dermatological surgery. A total of 1,977 procedures were reviewed. SSI was clinically suspected in 79 (4.0%) patients and confirmed by culture in 38 (1.9%). Using the stricte ...
Pages: 246-250
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INVESTIGATIVE REPORT
Search for RASA1 Variants in Capillary Malformations of the Legs in 113 Children: Results from the French National Paediatric Cohort CONAPE
Annabel Maruani, Marine Durieux-Verde, Juliette Mazereeuw-Hautier, Olivia Boccara, Ludovic Martin, Christine Chiaverini, Catherine Eschard, Nathalie Bénéton, Pierre Vabres, Xavier Balguerie, Patrice Plantin, Didier Bessis, Sébastien Barbarot, Ali Dadban, Catherine Droitcourt, Aline Berthelot, Gérard Lorette, Sophie Leducq, Mahtab Samimi, Christian Andres, Agnès Caille, Patrick Vourc'h; and Groupe de Recherche de la Société Française de Dermatologie
Patients with an inherited autosomal-dominant disorder, capillary malformation–arteriovenous malformation (CM-AVM), frequently have mutations in Ras P21 protein activator 1 (RASA1). The aims of this study were to determine the prevalence of germline RASA1 variants in a French multicentre national cohort of children, age range 2–12 years, with sporadic occurrence of capillary malformation (CM) ...
Pages: 251-255
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INVESTIGATIVE REPORT
Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy
Michael Brandwein, Garold Fuks, Avigail Israel, Ashraf Al-Ashhab, Deborah Nejman, Ravid Straussman, Emmilia Hodak, Marco Harari, Doron Steinberg, Zvi Bentwich, Noam Shental, Shiri Meshner
Dead Sea climatotherapy (DSC) is a therapeutic modality for a variety of chronic skin conditions, yet there has been scarce research on the relationship between the cutaneous microbiota and disease states in response to DSC. We characterized the skin bacterial and fungal microbiome of healthy volunteers who underwent DSC. Bacterial community diversity remained similar before and after treatment, w ...
Pages: 256-261
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INVESTIGATIVE REPORT
Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back
Marie-Ange Dagnelie, Stéphane Corvec, Mélanie Saint-Jean, Valérie Bourdès, Jean-Michel Nguyen, Amir Khammari, Brigitte Dréno
Propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: IA1, IA2, IB, IC, II and III. This study investigated P. acnes subgroups on the face and back in patients with severe acne and in healthy controls. In 71.4% of patients with severe acne, P. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy contr ...
Pages: 262-267
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INVESTIGATIVE REPORT
Placebo Effects of Open-label Verbal Suggestions on Itch
Stefanie H. Meeuwis, Henriët van Middendorp, Dieuwke S. Veldhuijzen, Antoinette I.M. van Laarhoven, Jan De Houwer, Adriana P.M. Lavrijsen, Andrea W.M. Evers
Placebo effects are positive outcomes that are not due to active treatment components, which may be elicited even when patients are aware of receiving an inert substance (open-label). This proof-of-principle study investigated for the first time whether open-label placebo effects on itch can be induced by verbal suggestions alone. Ninety-two healthy volunteers were randomized to experimental (open ...
Pages: 268-274
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SHORT COMMUNICATION
Late-onset Erythropoietic Protoporphyria Associated with Myelodysplastic Syndrome Treated with Azacitidine
Ai Yoshioka, Susumu Fujiwara, Hiroki Kawano, Hajime Nakano, Shigeru Taketani, Toshimitsu Matsui, Yoshio Katayama, Chikako Nishigori
Abstract is missing (Short communication)
Pages: 275-277
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SHORT COMMUNICATION
Allergic Contact Dermatitis Due to Ripasudil Hydrochloride Hydrate in Eye-drops: A Case Report
Minori Kusakabe, Yasutomo Imai, Masaru Natsuaki, Kiyofumi Yamanishi
Abstract is missing (Short communication)
Pages: 278-279
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SHORT COMMUNICATION
Heterogeneity of Skin Re-innervation After Burns and Factors Involved in its Regulation: A Pilot Study
Virginie Buhé, Alexandra Trimaille, Martine Schollhammer, Florence Morvan, Weiguo Hu, Christophe Egles, Alexis Desmoulière, Laurent Misery
Abstract is missing (Short communication)
Pages: 280-281
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SHORT COMMUNICATION
Central Obesity in Children with Psoriasis
Lucia Guidolin, Marco Borin, Elena Fontana, Francesca Caroppo, Stefano Piaserico, Anna Belloni Fortina
Abstract is missing (Short communication)
Pages: 282-283
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SHORT COMMUNICATION
Biological and Clinical Response to Omalizumab in a Patient with Bullous Pemphigoid
Sébastien Menzinger, Gürkan Kaya, Enno Schmidt, Lionel Fontao, Emmanuel Laffitte
Abstract is missing (Short communication)
Pages: 284-286
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SHORT COMMUNICATION
9q22.3 Microdeletion Syndrome with Multiple Basal Cell Carcinomas Treated with Vismodegib: Three Key Messages in One Patient
Alice Kieny, Valérie Kremer, Sophie Scheidecker, Dan Lipsker
Abstract is missing (Short communication)
Pages: 287-288
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SHORT COMMUNICATION
Modified Measles: A Diagnostic Challenge
Jozefien Roose, Celine Rohaert, Annelien Jadoul, Regina Fölster-Holst, Dirk van Gysel
Abstract is missing (Short communication)
Pages: 289-290
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SHORT COMMUNICATION
Post-traumatic Stress Disorder in Patients and Relatives Following a Diagnosis of De novo Neurofibromatosis Type 1
Johanna Huguen, Séverine Audebert-Bellanger, Emilie Brenaut, Laurent Misery, Claire Abasq-Thomas
Abstract is missing (Short communication)
Pages: 291-293
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QUIZ
An Asymptomatic Plaque on the Chest: A Quiz
Alessandro Pileri, Susanna Gunnella, Vieri Grandi, Vincenza Maio, Nicola Pimpinelli
Abstract is missing (Quiz)
Pages: 294-296
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QUIZ
Six-month History of a Split Thumbnail: A Quiz
Yosuke Mai, Hideyuki Ujiie, Takashi Anan, Hajime Miyazawa, Keisuke Imafuku, Kokichi Hamasaka, Hiroshi Shimizu
Abstract is missing (Quiz)
Pages: 297-298
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QUIZ
Chronic Nodular Dermatosis: A Quiz
Marco Cusini, Stefano Ramoni, Vinicio Boneschi, Sebastiano Recalcati
Abstract is missing (Quiz)
Pages: 299-300
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