Content

Content - Volume 99, Issue 13

Editor's choice in this issue

CLINICAL REPORT
Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study
Nikolai Dyrberg Loft, Alexander Egeberg, Mads Kirchheiner Rasmussen, Lars Erik Bryld, Robert Gniadecki, Tomas Norman Dam, Lars Iversen, Lone Skov
This registry study from DERMBIO demonstrate weak-to-moderate correlations between PASI and DLQI during a 5-year period and between changes in PASI and DLQI in patients treated with biologics or apremilast. Of all the questions of the DLQI, the first question on “Symptoms and feelings” was the one contributing most to the overall DLQI and this increased over time. The results of this study show that some of the questions of the DLQI might be redundant and additional measures to capture subjective symptoms might be beneficial in future studies and daily practice.
Pages: 1224-1230
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SHORT COMMUNICATION
Atopic Dermatitis-like Eruption Induced by Two Different Biologics in a Patient with Psoriatic Arthritis
Fumihito Abe, Shinji Mitsuyama, Eri Nagao, Masaaki Kimura, Tetsuya Higuchi
We experienced a patient with psoriatic arthritis who developed atopic dermatitis-like eruptions caused by administration of two different types of biologics, infliximab and ixekizumab. Skin biopsy revealed epidermal spongiosis and lymphocyte perivascular infiltration in upper dermis. It is suggested that atopic dermatitis-like eruptions are not a skin disorder specific to a drug but might occur in patients with psoriasis treated with any biologics. A possible reason for the development of atopic dermatitis-like eruptions is transition from Th1 to Th2 dominance by biologics.
Pages: 1291-1292
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All articles

REVIEW
Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions
Gil Yosipovitch, Laurent Misery, Ehrhardt Proksch, Martin Metz, Sonja Ständer, Martin Schmelz
Barrier damage, dry skin and itch are intricately linked and form the basis of many common skin diseases. Damage from environmental insults, or genetic or inflammatory causes, can impair the skin barrier, resulting in an increase in transepidermal water loss and activation of itch-associated nerve fibres. The itch-scratch cycle can perpetuate skin barrier damage and itch. Topical therapeutic strat ...
Pages: 1201-1209
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REVIEW
Outcome Measurements Used in Randomized Controlled Trials of Teledermatology: A Systematic Mapping Review
Aloysius Chow, Charlene Soon, Helen Elizabeth Smith, Christian J. Apfelbacher
Assessment of the effectiveness of teledermatology has been hampered by the variety of outcome measures used, limiting the possibility for meta-analysis. This systematic mapping review classified the outcome measurement instruments used in randomized controlled trials of teledermatology conducted between 2008 and 2018 using the Core Outcome Measures in Effectiveness Trials taxonomy. Sixteen articl ...
Pages: 1210-1217
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CLINICAL REPORT
Relationship of Visceral Fat and Adipokines with Cardiometabolic Diseases in Psoriasis
Nasrin Goolam Mahyoodeen, Nigel J. Crowther, Lushen Pillay, Tracy Snyman, Marketa Toman, Sheetal Daya, Mohammed Tikly
As part of a larger cross-sectional, case-control study on cardiometabolic diseases in psoriasis this study investigated the association of visceral fat and serum adipokines with psoriasis and cardiometabolic diseases. A total of 103 patients with psoriasis and 98 controls, matched for body mass index, ethnicity and sex, were recruited over 15 months. Abdominal visceral fat was measured by compute ...
Pages: 1218-1223
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CLINICAL REPORT
Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study
Nikolai Dyrberg Loft, Alexander Egeberg, Mads Kirchheiner Rasmussen, Lars Erik Bryld, Robert Gniadecki, Tomas Norman Dam, Lars Iversen, Lone Skov
The initiation and evaluation of treatment with biologics for psoriasis is based on the Psoriasis Area Severity Index (PASI) and/or Dermatological Life Quality Index (DLQI). However, these indices do not always correlate well, and changes in the DLQI do not always follow changes in the PASI. Based on data from the Danish national registry (DERMBIO), this study investigated the correlation between ...
Pages: 1224-1230
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CLINICAL REPORT
Clinical and Histological Characteristics of Mycosis Fungoides and Sézary Syndrome: A Retrospective, Single-centre Study of 43 Patients from Eastern Denmark
Pia Rude Nielsen, Jens Ole Eriksen, Ulrike Wehkamp, Lise Maria Lindahl, Robert Gniadecki, Hanne Fogh, Susanne Fabricius, Michael Bzorek, Niels Ødum, Lise Mette Rahbek Gjerdrum
Diagnosis of mycosis fungoides and Sézary syndrome can be very challenging. Clinical and histopathological data for patients with mycosis fungoides and Sézary syndrome in Denmark are limited. A retrospective study was performed in Region Zealand, Denmark from 1990 to 2016. A total of 43 patients with mycosis fungoides or Sézary syndrome were identified during the period. At the time of diagnos ...
Pages: 1231-1236
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CLINICAL REPORT
Duration of Efficacy Increases with the Repetition of Botulinum Toxin A Injections in Primary Axillary Hyperhidrosis: A 15-year Study in 117 Patients
Clémence Berthin, Hervé Maillard
Changes in the duration of efficacy of botulinum toxin A injections for primary axillary hyperhidrosis have not been studied in depth. The aim of this study was to assess such changes. In a retrospective cohort of 220 patients, seen over a 17-year period, duration of efficacy was recorded, including duration of efficacy of first and last injections. Of 220 patients, 117 fulfilled the study criteri ...
Pages: 1237-1240
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CLINICAL REPORT
Cutaneous Squamous Cell Carcinoma Tumour Size is Associated with Sentinel Lymph Node Metastasis in a Cohort of 69 Patients
Emilien Chabrillac, Amélie Lusque, Zoé Cavallier, Raphaël Lopez, Thomas Filleron, Jérôme Sarini, Nicolas Meyer, Sébastien Vergez
Ten to fifty percent of high-risk cutaneous squamous cell carcinoma may potentially metastasize. However, the concept of sentinel lymph node biopsy remains controversial for cutaneous squamous cell carcinoma. The aim of this study was to identify prognostic factors associated with sentinel lymph node positivity. A bicentric retrospective analysis was conducted between January 2006 and January 2018 ...
Pages: 1241-1245
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CLINICAL REPORT
Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits
Antonio Bonadies, Ettore Bertozzi, Renzo Cristiani, Flavio A. Govoni, Emilia Migliano
Skin malignancies of the head and neck inflict significant structural, functional, and cosmetic burdens upon those affected. We retrospectively addressed electrochemotherapy anti-tumour efficacy in head and neck skin cancer patients who were not suitable for standard treatments. Scars' physical characteristics and aesthetics were evaluated using validated scar assessment scales. Among 33 treated p ...
Pages: 1246-1252
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CLINICAL REPORT
Safety and Efficacy of Topically Applied Selected Cutibacterium acnes Strains over Five Weeks in Patients with Acne Vulgaris: An Open-label, Pilot Study
Ante Karoglan, Bernhard Paetzold, Joao Pereira De Lima, Holger Brüggemann, Thomas Tüting, Denny Schanze, Marc Güell, Harald Gollnick
Imbalance in skin microflora, particularly related to certain Cutibacterium acnes strains, may trigger acne. Application of non-acne-causing strains to the skin may modulate the skin microbiome and thereby lead to a reduction in acne. This pilot study evaluates the safety and efficacy of microbiome modulation on acne-prone skin. The study had 2 phases: active induction (5% benzoyl peroxide gel, 7 ...
Pages: 1253-1257
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INVESTIGATIVE REPORT
Multicomponent Biomarker Approach Improves the Accuracy of Diagnostic Biomarkers for Psoriasis Vulgaris
Ene Reimann, Freddy Lättekivi, Maris Keermann, Kristi Abram, Sulev Kõks, Külli Kingo, Alireza Fazeli
Accurate biomarker-based diagnosis of psoriasis vulgaris has remained a challenge; no reliable disease-specific biomarkers have yet been identified. There are several different chronic inflammatory skin diseases that can present similar clinical and dermoscopy features to psoriasis vulgaris, making accurate diagnosis more difficult. Both literature-based and data-driven selection of biomarker was ...
Pages: 1258-1265
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INVESTIGATIVE REPORT
Comparative Analyses of Tumour Volume Doubling Times for Periocular and Non-periocular Head and Neck Basal Cell Carcinomas
Andre Boo Shern Khoo, Patrick Kin Yoong Goon, Holger Sudhoff, Peter Kin Cho Goon
Basal cell carcinomas are the commonest solid malignancy in humans and thought to grow faster in the periocular region. We measured growth rates between periocular and non-periocular nodular basal cell carcinomas in the head and neck region from high-resolution digital photos and operative notes. The non-periocular basal cell carcinomas (head and neck) showed a mean tumour volume doubling time of ...
Pages: 1266-1269
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INVESTIGATIVE REPORT
Angiogenesis in Ocular and Extraocular Sebaceous Carcinoma
Ferdinand Toberer, Holger A. Haenssle, Arno Rütten, Dmitry Kazakov, Liubov Kastnerova, Alexander Enk, Wolfgang Hartschuh, Ines Bertlich, Julia Hartmann, Martin Laimer, Wolfgang Weyers, Peter Helmbold, Heinz Kutzner
To shed more light on the pathogenesis of sebaceous carcinoma, we analysed the expression of proteins related to angiogenesis in 18 ocular and 22 extraocular sebaceous carcinomas using a broad panel of immunohistochemical markers. To quantify the expression of D2-40, vascular endothelial growth factor, vascular endothelial growth factor receptor-2 and -3, we calculated a quantification score by co ...
Pages: 1270-1274
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INVESTIGATIVE REPORT
Increased Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Patients on Chronic Dialysis: A Cancer Registry-based Study in Taiwan
Chao-Hsiun Tang, Yuh-Mou Sue, Wen-Ting Hsieh, Ya-Hui Wang, Chia-Chen Wang
This study investigated the predominant skin cancer subtype among organ transplant recipients, patients on chronic dialysis, and patients with chronic kidney disease in Asian subjects. Among 23,644 patients with skin cancer, identified from Taiwan Cancer Registry Database, 53 were organ transplant recipients, 255 were on chronic dialysis, 1,792 had chronic kidney disease, and 21,544 were in the co ...
Pages: 1275-1281
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SHORT COMMUNICATION
Neutrophil-rich Variant of Persistent Bullous Grover’s Disease
Sayaka Togo, Kentaro Ozawa, Asami Fujii, Tsukasa Tanii, Daisuke Tsuruta, Norito Ishii, Takashi Hashimoto, Taketsugu Tadokoro, Taiki Isei
Abstract is missing (Short communication)
Pages: 1282-1283
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SHORT COMMUNICATION
Immunohistochemical Evaluation of Matrix Metalloproteinases-1, -9, Transient Receptor Potential Vanilloid Type 1, and CD117 in Granulomatous Rosacea Compared with Non-granulomatous Rosacea
Jong Bin Park, Kee Suck Suh, Ji Yun Jang, Seol Hwa Seong, Myeong Hyeon Yang , Jin Seuk Kang, Min Soo Jang
Abstract is missing (Short communication)
Pages: 1284-1285
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SHORT COMMUNICATION
Patch Testing with Isobornyl Acrylate in 16 Swedish Patients with Contact Dermatitis from Glucose Sensors and/or Insulin Pumps
Martin Mowitz, Louise Fornander, Sara Hosseiny, Kristina Ryberg, Magnus Bruze
Abstract is missing (Short communication)
Pages: 1286-1287
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SHORT COMMUNICATION
Minimal Clinically Important Difference in Chronic Pruritus Appears to be Dependent on Baseline Itch Severity
Claudia Riepe, Nani Osada, Adam Reich, Matthias Augustin, Claudia Zeidler, Sonja Ständer
Abstract is missing (Short communication)
Pages: 1288-1290
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SHORT COMMUNICATION
Atopic Dermatitis-like Eruption Induced by Two Different Biologics in a Patient with Psoriatic Arthritis
Fumihito Abe, Shinji Mitsuyama, Eri Nagao, Masaaki Kimura, Tetsuya Higuchi
Abstract is missing (Short communication)
Pages: 1291-1292
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SHORT COMMUNICATION
Possible Paradoxical Photosensitive Psoriasis Induced by Tumour Necrosis Factor-alpha Inhibitors
Pauline Bataille, Adèle De Masson, Marie-Dominique Vignon-Pennamen, Jean-David Bouaziz, Jean-Marc Gornet
Abstract is missing (Short communication)
Pages: 1293-1294
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SHORT COMMUNICATION
Vasculitis Mimicking Pseudo Erysipelas in Systemic Lupus Erythematosus
Morgane Weiss, Marie-Dominique Vignon, Clémence Lepelletier, Lou Macaux, Marie Jachiet, Adèle de Masson, Martine Bagot, Jean-David Bouaziz
Abstract is missing (Short communication)
Pages: 1295-1296
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SHORT COMMUNICATION
Severely Itching Dermatitis and Palmoplantar Keratoderma as First Manifestation of T-cell Prolympho­cytic Leukaemia
Silke C. Hofmann, Konstantin Koutcher, Mario Fabri, Linus Wahnschaffe, Marco Herling, Ekaterina Zilberman
Abstract is missing (Short communication)
Pages: 1297-1298
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SHORT COMMUNICATION
Epstein-Barr Virus-related Multi-site Mucocutaneous Ulcer: A Previously Undescribed Clinical Subset of a Rare Disease
Emilie Schwob, Vanessa Szablewski, Mathilde Lerisson, Olivier Dereure
Abstract is missing (Short communication)
Pages: 1299-1300
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SHORT COMMUNICATION
Multiple Keratoacanthoma-like Lesions in a Patient Treated with Pembrolizumab
Marion Fradet, Vincent Sibaud, Emilie Tournier, Laurence Lamant, Serge Boulinguez, Aurore Brun, Cecile Pages, Nicolas Meyer
Abstract is missing (Short communication)
Pages: 1301-1302
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SHORT COMMUNICATION
rs34567942 a Novel Susceptibility Single Nucleotide Polymorphism for Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients
Aleksandar Kuzmanov, Weihong Qi, Nadja Stenz, Pierre-Yves Bochud, Zoltan Kutalik, Agnieszka Wojtowicz, Günther Hofbauer
Abstract is missing (Short communication)
Pages: 1303-1304
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SHORT COMMUNICATION
Rosai-Dorfman Disease with Systemic Multiple Involvement: A Case Report
Jiangfan Yu, Bingsi Tang, Yaqian Shi, Puyu Zou, Guiying Zhang, Yan Ding, Rong Xiao
Abstract is missing (Short Communication)
Pages: 1305-1306
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SHORT COMMUNICATION
Oculodentodigital Dysplasia Diagnosed from Severe Hypotrichosis
Tomoki Taki, Takuya Takeichi, Kazumitsu Sugiura, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 1307-1308
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SHORT COMMUNICATION
Novel PLEC Variant Causes Mild Skin Fragility, Pyloric Atresia, Muscular Dystrophy and Urological Manifestations
Manthoula Valari, Martha Theodoraki, Ierotheos Loukas, Sylvia Gkantseva-Patsoura, Georgia Karavana, Vasiliki Falaina, Lilia Lykopoulou, Roser Pons, Ioannis Athanasiou, Katarzyna Wertheim-Tysarowska, Christina Kanaka-Gantenbein, Dimitra Kiritsi
Abstract is missing (Short communication)
Pages: 1309-1310
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SHORT COMMUNICATION
A Case of Malignant Melanoma Arising in Nagashima-type Palmoplantar Keratosis
Sho Katayama, Toshifumi Nomura, Masae Takeda, Toshinari Miyauchi, Shotaro Suzuki, Jin Teng Peh, Takuma Nohara, Shinya Kitamura, Hiroo Hata, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 1311-1312
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SHORT COMMUNICATION
Successful Treatment of Recurrent Cutaneous Purpureocillium lilacinum (Paecilomyces lilacinus) Infection with Posaconazole and Surgical Debridement
Wei-Yu Chen, Siao-Ru Lin, Sung-Jen Hung
Abstract is missing (Short communication)
Pages: 1313-1314
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SHORT COMMUNICATION
Multifocal Cutaneous Infections Caused by Mycobacterium szulgai without Pulmonary Involvement
Wei Zhang, Siyue Kan, Haiqin Jiang, Hongsheng Wang, Xiaofang Li, Jian-fang Sun
Abstract is missing (Short communication)
Pages: 1315-1316
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QUIZ
Eczematous, Pruritic, Brownish Plaque of the Nipple and Areola: A Quiz
Gloria Orlando, Dennis Linder, Stefano Piaserico, Mauro Alaibac, Roberto Salmaso
Abstract is missing (Quiz)
Pages: 1317-1318
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QUIZ
Long-lasting Tumour on the Upper Lip of a 28-year-old Woman: A Quiz
Stine Simonsen, Dorrit Krustrup, Annette Hougaard Chakera, Lone Skov
Abstract is missing (Quiz)
Pages: 1319-1321
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QUIZ
Generalized Skin Scaling in a Young Girl: A Quiz
Ran Mo, Huijun Wang, Zhimiao Lin
Abstract is missing (Quiz)
Pages: 1322-1323
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