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Content - Volume 97, Issue 3

HIGHLIGHTS

  • The ”Alarmins” HMBG1 and IL- 33 Downregulate Structural Skin Barrier Proteins
    Uffe Nygaard, Ellen H. van den Bogaard, Hanna Niehues, Malene Hvid, Mette Deleuran, Claus Johansen, Christian Vestergaard
  • Association Between Vitamin D Levels and Naevus Counts
    Simone Ribero, Dan Glass, Massimo Mangino, Abraham Aviv, Tim Spector, Veronique Bataille
  • Annular Eruptive Pseudoangiomatosis and Adenovirus Infection
    Antonio Chuh, Rüdiger Panzer, Ann-Christine Rosenthal, Ehrhardt Proksch, Werner Kempf, Vijay Zawar, Helmuth Fickenscher, Regina Fölster-Holst
  • Plaque Psoriasis Treated with Tonsillectomy
    Ragna Hlin Thorleifsdottir, Sigrun Laufey Sigurdardottir, Bardur Sigurgeirsson, Jón Hjaltalin Olafsson, Martin Ingi Sigurdsson, Hannes Petersen, Johann Eli Gudjonsson, Andrew Johnston, Helgi Valdimarsson
  • Male Lichen Sclerosus: Complications and Autoimmunity
    Despina Kantere, Gunilla Alvergren, Martin Gillstedt, Fani Pujol-Calderon, Petra Tunbäck
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Editor's choice in this issue

INVESTIGATIVE REPORT
The ”Alarmins” HMBG1 and IL-33 Downregulate Structural Skin Barrier Proteins and Impair Epidermal Growth
Uffe Nygaard, Ellen H. van den Bogaard, Hanna Niehues, Malene Hvid, Mette Deleuran, Claus Johansen, Christian Vestergaard
The epidermal-derived “alarmins” high-mobility group box 1 (HMGB1) protein and interleukin-33 (IL-33) are upregulated in patients with atopic dermatitis. How­ever, their capacity as pro-inflammatory cytokines and their derived effects on skin barrier regulation are poorly elucidated. We investigated the impact of HMGB1 and IL-33 on gene transcription, protein expression and epidermal differen ...
Pages: 305-312
Abstract  HTML  PDF
CLINICAL REPORT
Annular Eruptive Pseudoangiomatosis and Adenovirus Infection: A Novel Clinical Variant of Paraviral Exanthems and a Novel Virus Association
Antonio Chuh, Rüdiger Panzer, Ann-Christine Rosenthal, Ehrhardt Proksch, Werner Kempf, Vijay Zawar, Helmuth Fickenscher, Regina Fölster-Holst
Eruptive pseudoangiomatosis is a distinct exanthem thought to be caused by viruses. The usual rash configu­ration is erythematous papules and macules. An association with echovirus infection has been reported. We present here one adult and one child with this exanthem, supported by clinical, histopathological, and immunohistochemical findings. Both patients presented with prodromal symptoms, wide ...
Pages: 354-357
Abstract  HTML  PDF

All articles

INVESTIGATIVE REPORT
The ”Alarmins” HMBG1 and IL-33 Downregulate Structural Skin Barrier Proteins and Impair Epidermal Growth
Uffe Nygaard, Ellen H. van den Bogaard, Hanna Niehues, Malene Hvid, Mette Deleuran, Claus Johansen, Christian Vestergaard
The epidermal-derived “alarmins” high-mobility group box 1 (HMGB1) protein and interleukin-33 (IL-33) are upregulated in patients with atopic dermatitis. How­ever, their capacity as pro-inflammatory cytokines and their derived effects on skin barrier regulation are poorly elucidated. We investigated the impact of HMGB1 and IL-33 on gene transcription, protein expression and epidermal differen ...
Pages: 305-312
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo
Christos C. Zouboulis, Holger Seltmann, M. Badawy Abdel-Naser, Amir M. Hossini, Gopinathan K. Menon, Raj Kubba
Calcium and 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) are promoters of epithelial cell functions; however their effects on sebaceous glands are unknown. In this study, morphology, ultrastructure, cell numbers, lipid synthesis and apoptosis of SZ95 sebocytes were assessed in vitro under different concentrations of extracellular calcium with or without 1,25(OH)2D3. Moreover, serum calcium and 1,25(OH)2 ...
Pages: 313-320
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INVESTIGATIVE REPORT
Positive Association Between Vitamin D Serum Levels and Naevus Counts
Simone Ribero, Dan Glass, Massimo Mangino, Abraham Aviv, Tim Spector, Veronique Bataille
Lower vitamin D serum levels are linked to increased melanoma risk and poorer survival. Naevus counts are associated with both melanoma risk and survival and to leucocyte telomere length. Vitamin D is also linked to telomere biology with higher levels of vitamin D in individuals with longer leucocyte telomere length despite adjusting for age. Using the TwinsUK data, we explored the association bet ...
Pages: 321-324
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INVESTIGATIVE REPORT
CD1c+ Blood Dendritic Cells in Atopic Dermatitis are Premature and Can Produce Disease-specific Chemokines
Anikó Kapitány, Gabriella Béke, Georgina Nagy, Quang Minh Doan-Xuan, Zsolt Bacso, Krisztián Gáspár, Gábor Boros, Zsolt Dajnoki, Tamás Bíró, Éva Rajnavölgyi, Andrea Szegedi
Skin dendritic cells of patients with atopic dermatitis (AD) are well characterized, but less is known about their peripheral blood precursors. The aim of this study was to investigate the phenotypic features and chemokine production of myeloid pre-dendritic cells of patients with AD ex vivo and after stimulation with Staphylococcus enterotoxin B and thymic stromal lymphopoietin, representing an A ...
Pages: 325-331
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INVESTIGATIVE REPORT
Overweight and Weight Gain Predict Psoriasis Development in a Population-based Cohort
Kjersti Danielsen, Tom Wilsgaard, Anne Olaug Olsen, Anne-Sofie Furberg
Overweight is a proposed risk factor for psoriasis. How­ever, evidence from prospective studies is limited. The aim of this study was to investigate the association be­tween overweight, weight gain and risk of psoriasis, and potential synergism with smoking, within a population-based cohort including 8,752 individuals followed from 1994 up to 2008. There was a 32% increased odds of psoriasis fro ...
Pages: 332-339
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CLINICAL REPORT
Patient-reported Outcomes and Clinical Response in Patients with Moderate-to-severe Plaque Psoriasis Treated with Tonsillectomy: A Randomized Controlled Trial
Ragna Hlin Thorleifsdottir, Sigrun Laufey Sigurdardottir, Bardur Sigurgeirsson, Jón Hjaltalin Olafsson, Martin Ingi Sigurdsson, Hannes Petersen, Johann Eli Gudjonsson, Andrew Johnston, Helgi Valdimarsson
Psoriasis is a chronic inflammatory skin disease with profound effects on patients’ health-related quality of life (HRQoL). Twenty-nine patients with plaque psoriasis and a history of streptococcal-associated psoriasis exacerbations were randomly assigned to tonsillectomy (n = 15) or control (n = 14) groups and followed for 24 months. Patients were evaluated with the Psor ...
Pages: 340-345
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CLINICAL REPORT
Adalimumab Dose Tapering in Psoriasis: Predictive Factors for Maintenance of Complete Clearance
Katharina Hansel, Leonardo Bianchi, Francesco Lanza, Vittorio Bini, Luca Stingeni
Psoriasis can be managed successfully with long-term biologics. Real-life clinical practice may require dose tapering as a therapeutic option to reduce the risk of drug-exposure and to increase cost-effectiveness. The responsiveness to extended intervals between adalimumab doses and the possible predictive factors of maintenance of complete clearance were studied in a retrospective 7-year single-c ...
Pages: 346-350
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CLINICAL REPORT
Assessing the Concordance of Actinic Keratosis Counts on Digital Photographs with Clinical Examination in Organ Transplant Recipients
Zainab Jiyad, Peter O'Rourke, H. Peter Soyer, Adèle C. Green
Actinic keratoses (AKs) are common lesions that are usually diagnosed clinically. We sought to examine the accuracy of AK counts on digital photographs when compared with clinical examination counts. Skin sites of renal transplant recipients were examined clinically and on digital photographs by independent dermatologically-trained examiners. Specificity, sensitivity and Kendall’s tau-b correlat ...
Pages: 351-353
Abstract  HTML  PDF
CLINICAL REPORT
Annular Eruptive Pseudoangiomatosis and Adenovirus Infection: A Novel Clinical Variant of Paraviral Exanthems and a Novel Virus Association
Antonio Chuh, Rüdiger Panzer, Ann-Christine Rosenthal, Ehrhardt Proksch, Werner Kempf, Vijay Zawar, Helmuth Fickenscher, Regina Fölster-Holst
Eruptive pseudoangiomatosis is a distinct exanthem thought to be caused by viruses. The usual rash configu­ration is erythematous papules and macules. An association with echovirus infection has been reported. We present here one adult and one child with this exanthem, supported by clinical, histopathological, and immunohistochemical findings. Both patients presented with prodromal symptoms, wide ...
Pages: 354-357
Abstract  HTML  PDF
CLINICAL REPORT
Subcutaneous Panniculitis-like T-cell Lymphoma: Immunosuppressive Drugs Induce Better Response than Polychemotherapy
David Michonneau, Tony Petrella, Nicolas Ortonne, Saskia Ingen-Housz-Oro, Nathalie Franck, Stéphane Barete, Maxime Battistella, Marie Beylot-Barry, Béatrice Vergier, Marc Maynadié, Christine Bodemer, Olivier Hermine, Martine Bagot, Nicole Brousse, Sylvie Fraitag
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare condition usually considered to have a favourable prognosis. However, it is not known whether polychemotherapy or immunosuppressive-based therapy is the best approach for treating SPTCL. Using data collected between 2000 and 2012 in France, we analysed clinical, biological and pathological data of 27 patients with SPTCL. Medical hist ...
Pages: 358-364
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CLINICAL REPORT
Clinical Features, Complications and Autoimmunity in Male Lichen Sclerosus
Despina Kantere, Gunilla Alvergren, Martin Gillstedt, Fani Pujol-Calderon, Petra Tunbäck
Lichen sclerosus is a chronic inflammatory disease associated with substantial morbidity. Knowledge of the aetiology and progression of lichen sclerosus is therefore needed. In this cross-sectional study, 100 male patients diagnosed with lichen sclerosus were interviewed and examined. Since there is a possible link between lichen sclerosus and autoimmunity, blood tests were analysed for thyroid di ...
Pages: 365-369
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SHORT COMMUNICATION
Fibrinogen-like Protein 2 Activity as a Potential Biomarker for Diagnosis of Early Mycosis Fungoides
Shany Sherman, Esther Rabizadeh, Lilach Moyal, Tami Livnat, Esther Ziv, Izhack Cherny, Aida Inbal , Emmilia Hodak
Abstract is missing (Short communication)
Pages: 370-372
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SHORT COMMUNICATION
Topical Carmustine as Monotherapy or as Multimodality Therapy for Folliculotropic Mycosis Fungoides
Kelly M. MacArthur, Neha Jariwala, Ellen J Kim, Alain H. Rook
Abstract is missing (Short communication)
Pages: 373-374
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SHORT COMMUNICATION
Assessing Acute Itch Intensity: General Labelled Magnitude Scale is More Reliable than Classic Visual Analogue Scale
Olivia Jones, Igor C. Schindler, Henning Holle
Abstract is missing (Short communication)
Pages: 375-376
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SHORT COMMUNICATION
CD8+ T-cell-mediated Interface Dermatitis after CCR4+ T-cell Depletion by Mogamulizumab Treatment of Adult T-cell Leukaemia/lymphoma
Ayako Ito, Kazunari Sugita, Koji Adachi, Yuzuru Hosoda, Toru Motokura, Osamu Yamamoto
Abstract is missing (Short communication)
Pages: 377-378
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SHORT COMMUNICATION
Hydroa Vacciniforme-like Skin Lesions in Epstein-Barr-Virus-associated T-cell Lymphoproliferation with Subsequent Development of Aggressive NK/T-cell Lymphoma
Atiye Toksoy, Susanne Strifler, Sandrine Benoit, Götz U. Grigoleit, Stefan Knop, Stephan Mielke, Kristina Buder-Bakhaya, Sabine Roth, Matthias Goebeler, Andreas Rosenwald , Eva Geissinger, Marion Wobser
Abstract is missing (Short communication)
Pages: 379-380
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SHORT COMMUNICATION
Fibroblast Growth-factor 23 and Calcium-binding Proteins are not Associated with Chronic Itch in Patients on Haemodialysis
Thomas Mettang, Kevin Kunzmann, Heinz-Jürgen Roth, Elke Weisshaar
Abstract is missing (Short communication)
Pages: 381-382
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SHORT COMMUNICATION
Treatment of Oral Lesions in Dystrophic Epidermolysis Bullosa: A Case Series of Cord Blood Platelet Gel and Low-level Laser Therapy
Ezio Sindici, Simona Astesano, Luigina Fazio, Antonella Dragonetti, Mariateresa Pugliese, Crispian Scully, Stefano Carossa, Roberto Broccoletti, Paolo G. Arduino
Abstract is missing (Short communication)
Pages: 383-384
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SHORT COMMUNICATION
Chronic Pruritus in Primary Sjögren’s Syndrome: Characteristics and Effect on Quality of Life
Rodrigo Valdes-Rodriguez, Brandon Rowe , Helen G. Lee, Thais Moldovan, Yiong-Huak Chan, Marissa Blum, Gil Yosipovitch
Abstract is missing (Short communication)
Pages: 385-386
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SHORT COMMUNICATION
Extensive Post-zygotic Mosaicism of KRT1 or KRT10 Mutation Mimicking Classical Epider­molytic Ichthyosis
Maella Severino-Freire, Nathalie Jonca, Melanie Pichery, Emilie Tournier, Nicolas Chassaing, Juliette Mazereeuw-Hautier
Abstract is missing (short communication)
Pages: 387-388
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SHORT COMMUNICATION
Ustekinumab as Effective Treatment for Refractory Amicrobial Pustulosis of the Folds Associated with Crohn’s Disease
Reem Al-Raddadi, Camille Frances, Philippe Moguelet, Claude Bachmeyer, Sarah Guégan
Abstract is missing (Short communication)
Pages: 389-390
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SHORT COMMUNICATION
Lichen Planus in Irradiated Skin During Nivolumab Treatment
Takaya Komori, Tetsuya Honda, Hiroyuki Irie, Atsushi Otsuka, Kenji Kabashima
Abstract is missing (Short communication)
Pages: 391-392
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SHORT COMMUNICATION
Impact of Gliding on the Prevalence of Keratinocyte Carcinoma and its Precursors: A Cross-sectional Study Among Male Pilots in Bavaria
Alexander Zink, Ivonne Hänsel, Markus Rotter, Christoph D. Spinner, Alexander Böhner, Tilo Biedermann
Abstract is missing (Short communication)
Pages: 393-394
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SHORT COMMUNICATION
PD-1 Antibody-induced Guillain-Barré Syndrome in a Patient with Metastatic Melanoma
Roland Schneiderbauer, Malessa Schneiderbauer, Wolfgang Wick, Alexander H. Enk, Holger A. Haenssle, Jessica C. Hassel
Abstract is missing (Short communication)
Pages: 395-396
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SHORT COMMUNICATION
A Japanese Case of Ichthyosiform Erythroderma with a Novel Mutation in NIPAL4/Ichthyin
Minori Kusakabe, Makoto Nagai, Eiji Nakano, Orie Jitsukawa, Chikako Nishigori, Kiyofumi Yamanishi
Abstract is missing (Short communication)
Pages: 397-398
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SHORT COMMUNICATION
Striate Palmoplantar Keratoderma Showing Transgrediens in a Patient Harbouring Heterozygous Nonsense Mutations in Both DSG1 and SERPINB7
Ryo Fukaura, Takuya Takeichi, Yusuke Okuno, Daiei Kojima, Michihiro Kono, Kazumitsu Sugiura, Yasushi Suga, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 399-401
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SHORT COMMUNICATION
Fibroblast Growth Factor Receptor 3 Epidermal Naevus Syndrome with Urothelial Mosaicism for the Activating p.Ser249Cys FGFR3 Mutation
Didier Bessis, Julie Plaisancié, Véronique Gaston, Eric Bieth
Abstract is missing (Short communication)
Pages: 402-403
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SHORT COMMUNICATION
Linear IgA Bullous Dermatosis in a Pregnant Woman with Autoantibodies to the Non-collagenous 16A Domain of Type XVII Collagen
Kenshi Matsuura, Hideyuki Ujiie, Masahiro Hayashi, Ken Muramatsu, Junko Yoshizawa, Takamasa Ito, Hiroaki Iwata, Tamio Suzuki, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 404-405
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SHORT COMMUNICATION
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss) Relapsing as Bullous Eruption
Shany Sherman, Noa Gal, Elena Didkovsky, Yair Molad, Lev Pavlovsky, Emmilia Hodak
Abstract is missing (Short communication)
Pages: 406-407
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SHORT COMMUNICATION
Acute Lower Limb Ischaemia and Diabetes in a Patient Treated with Anti-PD1 Monoclonal Antibody for Metastatic Melanoma
Benjamin Thoreau, Flora Gouaillier-Vulcain, Laurent Machet, Christine Mateus, Caroline Robert, Nicole Ferreira-Maldent, François Maillot, Bertrand Lioger
Abstract is missing (Short communication)
Pages: 408-409
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SHORT COMMUNICATION
Impetigo Herpetiformis Complicated with Intrauterine Growth Restriction Treated Successfully with Granulocyte and Monocyte Apheresis
Natsuko Saito-Sasaki, Kunio Izu, Yu Sawada , Ryosuke Hino, Ryoji Nakano, Shohei Shimajiri, Izumi Nishimura, Hiromasa Nakamura, Kazumitsu Sugiura, Motonobu Nakamura
Abstract is missing (Short communication)
Pages: 410-411
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SHORT COMMUNICATION
Hurley Staging Refined: A Proposal by the Dutch Hidradenitis Suppurativa Expert Group
Barbara Horváth , Ineke C. Janse , Janine L. Blok, Rieke J. B. Driessen, Jurr Boer, Jan R. Mekkes, Errol P. Prens, Hessel H. van der Zee
Abstract is missing (Short communication)
Pages: 412-413
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QUIZ
Unusual Facial “Acne”: A Quiz
Aurélie Du-Thanh, Eric Frouin, Luc Durand, Valérie Costes, Olivier Dereure
Abstract is missing (Quiz)
Pages: 414-415
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SHORT COMMUNICATION
Waxing and Waning Bullous Hand Lesions: A Quiz
Sam Polesie, Maja Modin
Abstract is missing (Quiz)
Pages: 416-417
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QUIZ
Two Annular Alopecic Lesions on the Scalp in a Young Asian Man: A Quiz
Su-Kyung Park, Hyun-Bin Kwak, Seok-Kweon Yun, Han-Uk Kim, Jin Park
Abstract is missing (Quiz)
Pages: 418-419
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