Content

Content - Volume 97, Issue 4

HIGHLIGHTS

  • Methotrexate Use and Monitoring in Psoriasis
    Line Raaby, Claus Zachariae, Monika Østensen, Lene Heickendorff, Peter Thielsen, Henning Grønbæk, et al.
  • Senile Pruritus: From Diagnosis to Treatment
    Caroline-Jade Clerc, Laurent Misery
  • Impairment of Sexual Life in Dermatological Outpatients From 13 European Countries
    Francesca Sampogna, Damiano Abeni, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien,et al.
  • Characteristics of Melanoma in Organ Transplant Recipients
    Anabelle Brocard, Anne-Chantal Knol, Céline Bossard, Marc Guillaume Denis, Gaëlle Quéreux, Mélanie Saint-Jean, et al.
  • Bacterial Colonization in Hidradenitis Suppurativa/Acne Inversa
    Georgios Nikolakis, Aikaterini I. Liakou, Stefanos Bonovas, Holger Seltmann, Nikolaos Bonitsis, Olivier Join-Lambert, et al.
  • Quimp: A Word Meaning ”Quality of Life Impairment”
    Andrew Y. Finlay

Editor's choice in this issue

INVESTIGATIVE REPORT
Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis
Anna-Karin Ekman, Jenny Vegfors, Cecilia Bivik Eding, Charlotta Enerbäck
Psoriasin, which is highly expressed in psoriasis, is encoded by a gene located within the epidermal differentiation complex. The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. Immunohistochemical staining revealed a gradient of psoriasin expression in the psoriatic epidermis with highest expression in the suprabasal, ...
Pages: 441-448
Abstract  HTML  PDF
SHORT COMMUNICATION
Follicular Traction Urticaria: A New Form of Chronic Inducible Urticaria?
Nadia Raison-Peyron, Valérie Reymann, Didier Bessis
Abstract is missing (Short communication)
Pages: 522-523
Abstract  HTML  PDF
SHORT COMMUNICATION
Congenital Ichthyosis and Recurrent Eczema Associated with a Novel ALOXE3 Mutation
Takuya Takeichi, Yusuke Okuno, Chiyo Saito, Daiei Kojima, Michihiro Kono, Akimichi Morita, Kazumitsu Sugiura, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 532-533
Abstract  HTML  PDF

All articles

EDITORIAL
Software is Eating the Clinic
Jonathan L. Rees
Abstract is missing (Guest Editorial)
Pages: 423-424
Abstract  HTML  PDF
IN THIS ISSUE
Comment on: Quimp: A word meaning “quality of life impairment”
Pavel V. Chernyshov
Abstract is missing (In this Issue...)
Page: 425
Abstract  PDF
IN THIS ISSUE
Have you measured the patient’s quimp?
Magnus Lindberg
Abstract is missing (In this Issue...)
Page: 425
Abstract  PDF
SPECIAL REPORT
Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting
Line Raaby, Claus Zachariae, Monika Østensen, Lene Heickendorff, Peter Thielsen, Henning Grønbæk, Lone Skov, Nini Kyvsgaard, Jakob T. Madsen, Michael Heidenheim, Anne T. Funding, Gitte Strauss, Rune Lindberg, Lars Iversen
Methotrexate (MTX) has been used in the treatment of psoriasis and other dermatological diseases for more than 50 years. However, there is limited evidence regarding its effect, dose and monitoring, and a lack of consensus regarding how the drug should be used in daily practice. Although the use of MTX is governed by guidelines, such as the European S3-Guidelines and the National Institute for Hea ...
Pages: 426-432
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SPECIAL REPORT
A Literature Review of Senile Pruritus: From Diagnosis to Treatment
Caroline-Jade Clerc, Laurent Misery
Pruritus occurs frequently in the elderly population, but it has not been fully defined and its precise prevalence is unknown. Putative causes of pruritus are numerous and patients’ quality of life can be greatly reduced. In the absence of any specific cause, a diagnosis of senile pruritus is proposed, suggesting that itch is secondary to ageing. However, the relationship of pruritus with skin a ...
Pages: 433-440
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Overexpression of Psoriasin (S100A7) Contributes to Dysregulated Differentiation in Psoriasis
Anna-Karin Ekman, Jenny Vegfors, Cecilia Bivik Eding, Charlotta Enerbäck
Psoriasin, which is highly expressed in psoriasis, is encoded by a gene located within the epidermal differentiation complex. The aim of this study was to investigate the effect of endogenous psoriasin on disturbed keratinocyte differentiation in psoriasis. Immunohistochemical staining revealed a gradient of psoriasin expression in the psoriatic epidermis with highest expression in the suprabasal, ...
Pages: 441-448
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα – IL-23 – IL-17 Axis
Minna E. Kubin, Nina Kokkonen, Riitta Palatsi, Päivi M. Hägg, Juha P. Väyrynen, Virpi Glumoff, Kirsi-Maria Haapasaari, Tiina Hurskainen, Kaisa Tasanen
The effects of topical calcipotriol/betamethasone combination therapy and betamethasone monotherapy on inflammatory T-cell numbers and molecular markers were compared in patients with psoriasis. Combination therapy down-regulated the expression of tumour necrosis factor (TNF)-α, interleukin (IL)-23A, IL-17A, S100A7, CCL-20 and interferon (IFN)-γ in skin and TNF-α, IL-6, IL-23A, T-be ...
Pages: 449-455
Abstract  HTML  PDF
INVESTIGATIVE REPORT
The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients
Tiia Maria Luukkonen, Ville Kiiski, Maria Ahola, Johanna Mandelin, Hannele Virtanen, Minna Pöyhönen, Sirpa Kivirikko, Ida Surakka, Sakari Reitamo, Aarno Palotie, Markku Heliövaara, Eveliina Jakkula, Anita Remitz
The contribution of filaggrin null mutations to predicting atopic dermatitis (AD) treatment response is not clear, nor have such mutations been studied in the Finnish population. This study tested the association of the 4 most prevalent European FLG null mutations, the 2 Finnish enriched FLG null mutations, the FLG 12-repeat allele, and 50 additional epidermal barrier gene variants, with risk of A ...
Pages: 456-463
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INVESTIGATIVE REPORT
Increased Activity and Apoptosis of Eosinophils in Blister Fluids, Skin and Peripheral Blood of Patients with Bullous Pemphigoid
Judith Engmann, Urda Rüdrich, Georg Behrens, Eleni Papakonstantinou, Manuela Gehring, Alexander Kapp, Ulrike Raap
Bullous pemphigoid (BP) is an autoimmune blistering skin disease that is more common in elderly individuals. The aim of this study was to determine the functional activity of eosinophils in patients with BP compared with healthy donors. Blood, skin and blister-derived eosinophils were strongly activated in patients with BP, seen by increased surface expression of CD69 compared with controls. CD11b ...
Pages: 464-471
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INVESTIGATIVE REPORT
Molecular Characteristics of Mycobacterium tuberculosis Strains Isolated from Cutaneous Tuberculosis Patients in China
Haiqin Jiang, Yali Jin, Varalakshmi Vissa, Liangfen Zhang, Weijun Liu, Lianhua Qin, Kanglin Wan, Xiaocui Wu, Hongsheng Wang, Weida Liu, Baoxi Wang
Cutaneous tuberculosis (CTB) is probably underreported due to difficulties in detection and diagnosis. To address this issue, genotypes of Mycobacterium tuberculosis strains isolated from 30 patients with CTB were mapped at multiple loci, namely, RD105 deletions, spacer oligonucleotides, and Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeats (MIRU-VNTRs). Fifty-eight strains ...
Pages: 472-477
Abstract  HTML  PDF
INVESTIGATIVE REPORT
Impairment of Sexual Life in 3,485 Dermatological Outpatients From a Multicentre Study in 13 European Countries
Francesca Sampogna, Damiano Abeni, Uwe Gieler, Lucía Tomas-Aragones, Lars Lien, Géraldine Titeca, Gregor B.E. Jemec, Laurent Misery, Csanád Szabó, M. Dennis Linder, Andrea W.M. Evers, Jon Anders Halvorsen, Flora Balieva, Jacek C. Szepietowski, Dmitry V. Romanov, Servando E. Marron, Ilknur K. Altunay, Andrew Y. Finlay, Sam S. Salek, Jörg Kupfer, Florence Dalgard
Skin conditions may have a strong impact on patients’ sexual life, and thus influence personal relationships. Sexual issues are difficult to discuss directly in clinical practice, and a mediated instrument may be useful to capture such information. In this study item 9 of the Dermatology Life Quality Index was used to collect information on sexual impact of several skin conditions in 13 European ...
Pages: 478-482
Abstract  HTML  PDF
CLINICAL REPORT
Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients
Anabelle Brocard, Anne-Chantal Knol, Céline Bossard, Marc Guillaume Denis, Gaëlle Quéreux, Mélanie Saint-Jean, Lucie Peuvrel, Amir Khammari, Gilles Blancho, Jacques Dantal, Brigitte Dréno
The aims of this study were to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment by immunohistochemical study of the expression of indoleamine 2,3-dioxygenase (IDO), PD1, PD-L1, CD8 and FoxP3. The study population comprised patients who had undergon ...
Pages: 483-488
Abstract  HTML  PDF
CLINICAL REPORT
Paediatric Erythema Multiforme: Epidemiological, Clinical and Laboratory Characteristics
Yael Siedner-Weintraub, Itai Gross, Almog David, Shimon Reif, Vered Molho-Pessach
Erythema multiforme (EM) is an immune-mediated reaction presenting as acrofacial target lesions. Most studies utilize the outdated classification, which includes EM, Stevens–Johnson syndrome and toxic epidermal necrolysis as related entities. We describe here epidemiological, aetiological, clinical, laboratory and treatment characteristics of paediatric EM. This is a retrospective single-centre ...
Pages: 489-492
Abstract  HTML  PDF
CLINICAL REPORT
Bacterial Colonization in Hidradenitis Suppurativa/Acne Inversa: A Cross-sectional Study of 50 Patients and Review of the Literature
Georgios Nikolakis, Aikaterini I. Liakou, Stefanos Bonovas, Holger Seltmann, Nikolaos Bonitsis, Olivier Join-Lambert, Thomas Wild, Ioannis Karagiannidis, Silvia Zolke-Fischer, Klaus Langner, Christos C. Zouboulis
It is unclear whether bacterial colonization in hidradenitis suppurativa/acne inversa (HS) comprises a primary cause, triggering factor or secondary phenomenon of the disease pathogenesis. Furthermore, the connection between certain bacterial species, the disease severity and its localization is unknown. Bacterial species were isolated from HS lesions to reveal a potential correlation with localiz ...
Pages: 493-498
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CLINICAL REPORT
Becker Naevus Syndrome of the Lower Body: One Case and Review of the Literature
Kristina Schäfer, Boris Bauer, Julian Donhauser, Andreas Kerstan, Henning Hamm
Becker naevus syndrome is a rare epidermal naevus syndrome defined by the co-occurrence of a Becker naevus with various cutaneous, muscular and skeletal anomalies. In the majority of cases, abnormalities exclusively consist of ipsilateral hypoplasia of the breast, areola and/or nipple in addition to the naevus. Here, we report on a 42-year-old woman with an extensive Becker naevus reaching from th ...
Pages: 499-504
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CLINICAL REPORT
Clinical Aspects of Itch in Lichen Planus
Kalina Welz-Kubiak, Adam Reich, Jacek C. Szepietowski
Lichen planus (LP) skin lesions are often accompanied by itch, but this symptom has not been thoroughly examined in LP. To better characterize itch in LP, 78 patients with LP were investigated. Itch was present in 94.9% of patients and was usually described as the most vexing symptom of LP. The mean?±?SD severity of itch according to visual analogue scale score was 6.9?±?2.8 points. Most patient ...
Pages: 505-508
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CLINICAL REPORT
Trichotillomania Among Young Adults: Prevalence and Comorbidity
Magdalena Grzesiak, Adam Reich, Jacek C. Szepietowski, Tomasz Hadryś, Przemysław Pacan
Trichotillomania is an impulse control disorder characterized by repetitive pulling out of one’s hair. The aim of this study was to estimate the prevalence of trichotillomania in young adults and its association with anxiety and obsessive-compulsive disorders (OCD). A total of 339 individuals completed a questionnaire to determine the presence of trichotillomania. OCD and anxiety disorders were ...
Pages: 509-512
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SHORT COMMUNICATION
Nocturnal Pruritus: Prevalence, Characteristics, and Impact on ItchyQoL in a Chronic Itch Population
Michael Joseph Lavery, Carolyn Stull, Leigh A. Nattkemper, Kristen M. Sanders, Helen Lee, Shwetapadma Sahu, Rodrigo Valdes-Rodriguez, Yiong-Huak Chan, Gil Yosipovitch
Abstract is missing (Short communication)
Pages: 513-515
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SHORT COMMUNICATION
Factors Associated with Receiving Biologics or Classic Systemic Therapy for Moderate-to-Severe Psoriasis: Evidence from the PSONET Registries
Paula Davila-Seijo, Ignacio Garcia-Doval, Luigi Naldi, Simone Cazzaniga, Matthias Augustin, Stephan J. Rustenbach, Esteban Daudén, Tomas Norman Dam, Chris Baker, Phyllis I. Spuls, Robert S. Stern, Arnon D. Cohen
Abstract is missing (Short communication)
Pages: 516-518
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SHORT COMMUNICATION
Psoriatic Arthritis, but not Psoriasis, is Associated with Primary Adrenal Insufficiency
Peter Jensen, Alexander Egeberg, Jacob P. Thyssen, Gunnar Gislason, Lone Skov
Abstract is missing (Short communication)
Pages: 519-521
Abstract  HTML  PDF
SHORT COMMUNICATION
Follicular Traction Urticaria: A New Form of Chronic Inducible Urticaria?
Nadia Raison-Peyron, Valérie Reymann, Didier Bessis
Abstract is missing (Short communication)
Pages: 522-523
Abstract  HTML  PDF
SHORT COMMUNICATION
Treatment of Refractory Chronic Spontaneous Urticaria with Adalimumab
Nannie Bangsgaard, Lone Skov, Claus Zachariae
Abstract is missing (Short communication)
Pages: 524-525
Abstract  HTML  PDF
SHORT COMMUNICATION
Psoriasis as a Manifestation of an Immune Reconstitution in Two Patients with Hepatitis C Treated with Ledipasvir/Sofosbuvir
Franz Heppt, Michael Sticherling
Abstract is missing (Short communication)
Pages: 526-527
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SHORT COMMUNICATION
Linear IgA Bullous Dermatosis Associated with Immunoglobulin Light-chain Amyloidosis
Yasuyuki Yamaguchi, Hideyuki Ujiie, Hiroyuki Ohigashi, Hiroyuki Iwata, Ken Muramatsu, Tomoyuki Endou, Takanori Teshima, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 528-529
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SHORT COMMUNICATION
A Novel De novo Mutation of the SASH1 Gene in a Chinese Family with Multiple Lentigines
Jianbo Wang, Jia Zhang, Xueli Li, Zhexin Wang, Dongchun Lei, Guofang Wang, Jianguo Li, Shoumin Zhang, Zhenlu Li, Ming Li
Abstract is missing (Short communication)
Pages: 530-531
Abstract  HTML  PDF
SHORT COMMUNICATION
Congenital Ichthyosis and Recurrent Eczema Associated with a Novel ALOXE3 Mutation
Takuya Takeichi, Yusuke Okuno, Chiyo Saito, Daiei Kojima, Michihiro Kono, Akimichi Morita, Kazumitsu Sugiura, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 532-533
Abstract  HTML  PDF
SHORT COMMUNICATION
Primary Cutaneous T-cell Lymphoma with Aberrant Expression of CD20
Verena Gerlinde Frings, Sabine Roth, Anna-Liisa Riedmiller, Kristina Schäfer, Matthias Goebeler, Andreas Rosenwald , Eva Geissinger, Marion Wobser
Abstract is missing (Short communication)
Pages: 534-536
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SHORT COMMUNICATION
Human Herpesvirus-7 Papular Rash in a Healthy Adult Patient
Valeria Brazzelli, Chiara Giorgini, Stefania Barruscotti, Giorgio A. Croci, Giovanni Borroni
Abstract is missing (Short communication)
Pages: 537-538
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SHORT COMMUNICATION
Development of Papulopustular Rosacea during Nivolumab Therapy for Metastatic Cancer
Emilie Bousquet, Allison Zarbo, Emilie Tournier, Christine Chevreau, Julien Mazieres, Mario E. Lacouture, Vincent Sibaud
Abstract is missing (Short communication)
Pages: 539-540
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SHORT COMMUNICATION
A Compensating Skin Care Complex Containing Pro-xylane in Menopausal Women: Results from a Multicentre, Evaluator-blinded, Randomized Study
Anne Bouloc , Elia Roo, Alain Moga, Bernard Chadoutaud , Christos C. Zouboulis
Abstract is missing (Short communication)
Pages: 541-542
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SHORT COMMUNICATION
Prevalence of Mycoplasma genitalium Infection and Relationship with Symptoms Among Adults Attending a Sexual Health Centre
Maeva Lefebvre, Julie Coutherut, Sophie Gibaud, Charlotte Biron, Marine Chalopin, Claire Bernier, François Raffi
Abstract is missing (Short communication)
Pages: 543-545
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CORRESPONDENCE
Quimp: A Word Meaning “Quality of Life Impairment”
Andrew Y. Finlay
Abstract is missing (Correspondence)
Pages: 546-547
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QUIZ
Pigmented Intertriginous Lesions and Bullous Plaques: A Quiz
Magdalena Zychowska, Aleksandra Batycka-Baran, Joanna Maj, Jacek C. Szepietowski, Wojciech Baran
Abstract is missing (Quiz)
Pages: 548-549
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QUIZ
Erythematous Grouped Papules and Plaque on an Intra-articular Injection Area: A Quiz
Young Min Cho, Joong Sun Lee, Dae Won Koo, Kyung Eun Jung
Abstract is missing (Quiz)
Pages: 550-551
Abstract  HTML  PDF