Acta Dermato-Venereologica - Content - Volume 98, Issue 1
Content

Content - Volume 98, Issue 1

Editor's choice in this issue

REVIEW
Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis
Kazuhisa Furue, Kazuhiko Yamamura, Gaku Tsuji, Chikage Mitoma, Hiroshi Uchi, Takeshi Nakahara, Makiko Kido-Nakahara, Takafumi Kadono, Masutaka Furue
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. ...
Pages: 5-13
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INVESTIGATIVE REPORT
Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increased, compared with controls, in the serum and in lesional vs. non-lesional skin of the patients, resp ...
Pages: 26-31
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EDITORIAL
Change of Editors and other News from ActaDV
Artur Schmidtchen and Agneta Andersson
Pages: 3-4
Abstract  PDF

All articles

EDITORIAL
Change of Editors and other News from ActaDV
Artur Schmidtchen and Agneta Andersson
Pages: 3-4
Abstract  PDF
REVIEW
Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis
Kazuhisa Furue, Kazuhiko Yamamura, Gaku Tsuji, Chikage Mitoma, Hiroshi Uchi, Takeshi Nakahara, Makiko Kido-Nakahara, Takafumi Kadono, Masutaka Furue
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these disorders. Recently, functional activation of the IL-36 receptor (IL-36R) was discovered to be another driving force in the pathogenesis of psoriasis. ...
Pages: 5-13
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SPECIAL REPORT
Granuloma Faciale Treatment: A Systematic Review
Claudia Lindhaus, Peter Elsner
Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. The publications are mainly indi ...
Pages: 14-18
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INVESTIGATIVE REPORT
Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Function
Kiyoko Yamada, Kenji Matsushita, Jingshu Wang, Takuro Kanekura
Atopic dermatitis (AD) is a chronic inflammatory skin disease. Corticosteroids, which are widely used for AD treatment, have adverse effects, and alternative treatments are urgently needed. This study examined the effect of topical application of high-dose glucose on inflamed skin in a murine model of AD. High-dose glucose treatment on the ear reduced dermatitis scores and ear thicknesses in mite ...
Pages: 19-25
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INVESTIGATIVE REPORT
Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increased, compared with controls, in the serum and in lesional vs. non-lesional skin of the patients, resp ...
Pages: 26-31
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INVESTIGATIVE REPORT
Agreeableness as Predictor of Induced Scratching in Patients with Atopic Dermatitis: A Replication Study
Christina Schut, Katharina Reinisch, Alexander Classen, Sarah Andres, Uwe Gieler, Jörg Kupfer
In patients with atopic dermatitis agreeableness and public self-consciousness have previously been shown to be significant predictors of induced scratching, while depression was significantly related to induced itch. This study aimed to replicate these findings. Itch and scratching were induced by videos of crawling insects or skin diseases. Induced itch was measured using a visual analogue scale ...
Pages: 32-37
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INVESTIGATIVE REPORT
Validation of Pruritus Measures Gathered with the Electronic Patient-reported Outcome System MoPat
Michael Storck, Claudia Zeidler, Mirjam Rehr, Claudia Riepe, Martin Dugas, Sonja Ständer, Iñaki Soto-Rey
In order to improve diagnosis and treatment, physicians require information about the social context and quality of life of their patients. The Center for Chronic Pruritus at the University Hospital Münster achieves this goal using the electronic patient-reported outcome system "Mobile Patient Survey", which assesses pruritus and quality of life measures. The aim of this study is to evaluate the ...
Pages: 38-43
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INVESTIGATIVE REPORT
Evaluation of a Rapid, Fully Automated Platform for Detection of BRAF and NRAS Mutations in Melanoma
Fanny Barel, Briac Guibourg, Laetitia Lambros, Glen Le Flahec, Pascale Marcorelles, Arnaud Uguen
BRAF and NRAS genetic analyses are time-consuming and can delay treatment choices in patients with metastatic melanomas presenting with acute deterioration. We compared the rapid, real-time, fully automated molecular diagnosis platform Idylla™ with next-generation sequencing (NGS) and immunohistochemistry for detection of BRAF and NRAS mutations in 36 patients with metastatic melanomas. The Idyl ...
Pages: 44-49
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INVESTIGATIVE REPORT
Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization
Malgorzata Kolesnik, Ingolf Franke, Anke Lux, Sven R. Quist, Harald P. Gollnick
Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed "eczema in psoriatico" (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was performed ...
Pages: 50-58
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INVESTIGATIVE REPORT
Rasch Analysis of the Dermatology Life Quality Index Reveals Limited Application to Chinese Patients with Skin Disease
Zehui He, Riccardo Lo Martire, Chuanjian Lu, Hongxia Liu, Lin Ma, Ying Huang, Yongmei Li, Liyun Sun, Yanping Bai, Wali Liu, Xushan Zha
The objective of this study was to examine the psychometric properties of the Chinese version of the Dermatology Life Quality Index (DLQI) and to assess the invariance of its items with respect to several patient parameters via Rasch analysis. Data were aggregated from 9,845 patients with various skin diseases across 9 hospitals in different regions of China. The response structure, local independ ...
Pages: 59-64
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INVESTIGATIVE REPORT
The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966
Suvi-Päivikki Sinikumpu, Laura Huilaja, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Markku Timonen, Kaisa Tasanen
Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade in ...
Pages: 65-69
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CLINICAL REPORT
Epidemiology and Outcome of Squamous Cell Carcinoma in Epidermolysis Bullosa in Australia and New Zealand
Minhee Kim, Minmin Li, Lizbeth R.A. Intong-Wheeler, Kim Tran, Damian Marucci, Dedee F. Murrell
We investigate the epidemiology and outcomes of squamous cell carcinoma (SCC) in recessive dystrophic epidermolysis bullosa (RDEB) from the Australasian EB registry cohort. Seventeen out of 49 (34.6%) RDEB patients developed at least one SCC. Data detailing SCC was obtainable from 16/17 RDEB-SCC patients. A total number of 161 primary SCCs occurred in 16 RDEB-SCC patients with a mean of 10 SCCs pe ...
Pages: 70-76
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CLINICAL REPORT
Incidence and Regression of Actinic Keratoses in Organ Transplant Recipients
Zainab Jiyad, Louise Marquart, Peter O'Rourke, Adèle C. Green
Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models ...
Pages: 77-81
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CLINICAL REPORT
Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies
Manuel P. Pereira, Hannah Lüling, Annette Dieckhöfer, Sabine Steinke, Claudia Zeidler, Sonja Ständer
Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical caps ...
Pages: 82-88
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CLINICAL REPORT
Psychological Health Status and Health-related Quality of Life in Adults with Atopic Dermatitis: A Nationwide Cross-sectional Study in South Korea
Sul Hee Lee, Si Hyung Lee, Sung Yul Lee, Bora Lee, Sang-Hoon Lee, Young Lip Park
Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Patients with AD often experience psychological distress and poor health-related quality of life (HRQoL). The aim of this study was to investigate the association of several psychological health statuses and poor HRQoL in an adult population with AD in South Korea. A total of 37,578 adults who participated in the Korean National Healt ...
Pages: 89-97
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CLINICAL REPORT
Long-term Impact of Ixekizumab on Psoriasis Itch Severity: Results from a Phase III Clinical Trial and Long-term Extension
Alexandra B. Kimball, Thomas Luger, Alice Gottlieb, Luis Puig, Roland Kaufmann, Russel Burge, Chen-Yen Lin, Gil Yosipovitch
Itching is a prevalent plaque psoriasis symptom. Ixekizumab, an IL-17A antagonist, has demonstrated rapid, significant improvements in itch severity over 12 weeks in Phase III psoriasis trials (UNCOVER-1, UNCOVER-2). We assessed the long-term (through 60 weeks) effect of ixekizumab maintenance therapy (80-mg ixekizumab every 4 weeks [IXEQ4W]) on itch severity, using the Itch Numeric Rating Scale, ...
Pages: 98-102
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CLINICAL REPORT
Hyperhidrosis Substantially Reduces Quality of Life in Children: A Retrospective Study Describing Symptoms, Consequences and Treatment with Botulinum Toxin
Sandra Eriksson Mirkovic, Alma Rystedt, Mie Balling, Carl Swartling
Studies on children with hyperhidrosis are sparse. This retrospective study presents clinical data and quality of life, along with treatment effect and safety of botulinum toxin (BTX). Case reports from 366 children were included to capture the medical history of hyperhidrosis. The total median score of the Dermatology Life Quality Index before treatment was 11 for children aged 16–17 years and ...
Pages: 103-107
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CLINICAL REPORT
Distinct Patterns and Aetiology of Chromonychia
Soo Hyeon Bae, Min Young Lee, Jee-Bum Lee
Abnormal colouring of the nails may be a sign of underlying systemic or local disorders. This study investigated the prevalence and causes of chromonychia as a whole, as well as of each subtype. Among 163 patients with chromonychia, trauma was the pathogenesis in up to 20.9% (34/163) of cases. The most common subtype was melanonychia (54.0%; 88/163), followed by leukonychia (23.9%), red (8.6%), gr ...
Pages: 108-113
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SHORT COMMUNICATION
Bowen’s Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision
Maud Henriette Elisabeth Jansen, Diebrecht Appelen, Patty J. Nelemans, Veronique J. Winnepenninckx, Nicole W.J. Kelleners-Smeets, Klara Mosterd
Abstract is missing (Short communication)
Pages: 114-115
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SHORT COMMUNICATION
Photodynamic Therapy: Influence of Clinical and Procedure Variables on Treatment Response in Basal Cell Carcinoma and Bowen Disease
Tamara Gracia-Cazaña, Marta Mascaraque, Nerea Salazar, Jesús Vera-Álvarez, María Pilar Frías, Salvador González, Ángeles Juarranz, Yolanda Gilaberte
Abstract is missing (Short communication)
Pages: 116-118
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SHORT COMMUNICATION
Extensive Eruptive Syringoma After Liver Transplantation
Takuya Maeda, Ken Natsuga, Wataru Nishie, Kenichiro Yamashita, Hiroshi Shimizu
Abstract is missing (Short communication)
Pages: 119-120
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SHORT COMMUNICATION
Successful Treatment of Epidermal Nevus-associated Pruritus with Topical Ketamine–Amitriptyline–Lidocaine
Jose A. Jaller, Gil Yosipovitch
Abstract is missing (Short communication)
Pages: 121-122
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SHORT COMMUNICATION
Primary Cutaneous CD30+ Lymphoproliferative Disorders in a Patient with Severe Atopic Dermatitis: Is There a Causative Link?
Magdalena Zychowska, Zdzisław Woźniak, Joanna Maj
Abstract is missing (Short communication)
Pages: 123-125
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SHORT COMMUNICATION
Locally Aggressive Trichoblastic Tumours (Low-grade Trichoblastic Carcinomas): Clinicopathological Analysis and Follow-up
Camille Hua, Charles Velter, Amelie Osio, Céleste Lebbe, Nicole Basset-Seguin, Bernard Cribier, Maxime Battistella
Abstract is missing (Short communication)
Pages: 126-127
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SHORT COMMUNICATION
Primary Cutaneous Aggressive Epidermotropic CD8+ T-cell Lymphoma with Brain Involvement and Mimicking Dermatomyositis
Hitoshi Terui, Kenshi Yamasaki, Saaya Yoshida, Setsuya Aiba
Abstract is missing (Short communication)
Pages: 128-129
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SHORT COMMUNICATION
Ichthyosis with Confetti Inherited from a Mosaic Father
Kristine A.U. Pallesen, Ole Clemmensen, Judith Fischer, Jens Michael Hertz, Anette Bygum
Abstract is missing (Short communication)
Pages: 130-131
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SHORT COMMUNICATION
Multiple Basal Cell Carcinoma Arising in a Verrucous Epidermal Naevus: Clinical, Histological and Therapeutic Observations
Francesca Satolli, Miriam Rovesti, Maria Beatrice De Felici, Alfredo Zucchi, Calogero Pagliarello, Claudio Feliciani
Abstract is missing (Short communication)
Pages: 132-133
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SHORT COMMUNICATION
Epstein-Barr Virus-related Acute Genital Ulcer Successfully Treated with Colchicine
Agathe Nouchi, Gentiane Monsel, Barthélémy Lafon-Desmurs, Laurence Meng, Sonia Burrel, Micheline Moyal-Barracco, Eric Caumes
Abstract is missing (Short communication)
Pages: 134-135
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SHORT COMMUNICATION
Adult Staphylococcal Scalded Skin Syndrome Successfully Treated with Multimodal Therapy Including Intravenous Immunoglobulin
Toru Urata, Michihiro Kono, Yuka Ishihara, Masashi Akiyama
Abstract is missing (Short communication)
Pages: 136-137
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SHORT COMMUNICATION
Staphylococcal Scalded Skin Syndrome Caused by a Rare Variant of Exfoliative-toxin-A+ S. aureus in an Adult Immunocompromised Woman
Simona Saluzzo, Franziska Layer, Georg Stingl, Georg Stary
Abstract is missing (Short communication)
Pages: 138-139
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SHORT COMMUNICATION
Light Chain Deposition Disease with Bullous Skin Lesions Mimicking Atypical Bullous Pemphigoid
Marion Malphettes, Pauline Bonnet, Pierre Schneider, Marguerite Vignon, Marine Baron, Jean-David Bouaziz, Maxime Battistella
Abstract is missing (Short communication)
Pages: 140-141
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SHORT COMMUNICATION
Assessment of Quality of Life in Chronic Pruritus: Relationship Between ItchyQoL and Dermatological Life Quality Index in 1,150 Patients
Astrid Stumpf, Bettina Pfleiderer, Fleur Fritz, Nadi Osada, Suephy C. Chen, Sonja Ständer
Abstract is missing (Short communication)
Pages: 142-143
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SHORT COMMUNICATION
Dystrophic Calcification in a Patient with Primary Localized Cutaneous Nodular Amyloidosis: An Uncommon Ultrasound Finding
Sergi Planas-Ciudad, Esther Roé Crespo, Juan Francisco Mir-Bonafé, Fania Zamantta Muñoz-Garza, Luis Puig
Abstract is missing (Short communication)
Pages: 144-145
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SHORT COMMUNICATION
Predominant Contribution of CD4 T Cells to Human Herpesvirus 6 (HHV-6) Load in the Peripheral Blood of Patients with Drug-induced Hypersensitivity Syndrome and Persistent HHV-6 Infection
Fumi Miyagawa, Yuki Nakamura, Rie Ommori, Kazuya Miyashita, Hiroshi Iioka, Natsuki Miyashita, Mitsuko Nishikawa, Yukiko Himuro, Kohei Ogawa, Hideo Asada
Abstract is missing (Short communication)
Pages: 146-148
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SHORT COMMUNICATION
Pre-emptive Evaluation of Venom Allergy in a Patient with Systemic Mastocytosis
Theo Gülen, Cem Akin
Abstract is missing (Short communication)
Pages: 149-150
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SHORT COMMUNICATION
Successful Treatment of Severe Recalcitrant Hidradenitis Suppurativa with the Interleukin-17A Antibody Secukinumab
Anna Schuch, Tatjana Fischer, Alexander Boehner, Tilo Biedermann, Thomas Volz
Abstract is missing (Short communication)
Pages: 151-152
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SHORT COMMUNICATION
Clinical Characteristics of the Halo Phenomenon in Infants with Neurofibromatosis 1: A Case Series
Monji Koga, Yuichi Yoshida, Shinichi Imafuku
Abstract is missing (Short communication)
Pages: 153-154
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SHORT COMMUNICATION
Dermatofibrosarcoma Protuberans Presenting as a Large Atrophic Plaque on the Chest
Ryosuke Saigusa, Takuya Miyagawa, Satoshi Toyama, Jun Omatsu, Tomomitsu Miyagaki, Yuri Masui, Daisuke Yamada, Shinichi Sato
Abstract is missing (Short communication)
Pages: 155-156
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SHORT COMMUNICATION
Need for Improved Definition of ”Chronic Wounds” in Clinical Studies
Bhone Myint Kyaw, Krister Järbrink, Laura Martinengo, Josip Car, Keith Harding, Artur Schmidtchen
Abstract is missing (Short communication)
Pages: 157-158
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QUIZ
Crusted Nodules on the Lower Left Arm in a Traveller Returning from South America: A Quiz
Ugur Uslu, Michael Erdmann, Stefan Schliep, Michael Sticherling
Abstract is missing (Quiz)
Pages: 159-160
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QUIZ
Long-standing Verrucous Plaques on the Buttocks: A Quiz
Dong Hyuk Eun, Jun Young Kim, Yoon Hyuk Choi, Yong Hyun Jang
Abstract is missing (Quiz)
Pages: 161-162
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QUIZ
Disseminated Vesicular Rash in an Immunocompetent Adult Woman: A Quiz
Trine Høgsberg, Anette Bygum
Abstract is missing (Quiz)
Pages: 163-164
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QUIZ
Dome-shaped Papules on the Left Flank: A Quiz
Sophie Roenneberg, Ivan Hegyi, Werner Kempf, Katrin Kerl, Emmanuella Guenova
Abstract is missing (Quiz)
Pages: 165-166
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CORRESPONDENCE
Psoriasis is More Prevalent than Indicated by Egeberg et al.’s Danish Study: A Comment
Petter Gjersvik
Abstract is missing (Correspondence)
Pages: 167-168
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CORRESPONDENCE
Differential Diagnosis of Erythema Multiforme in Childhood: A Comment to Siedner-Weintraub et al.
Gregorio P. Milani, Sebastiano A.G. Lava, Mario G. Bianchetti
Abstract is missing (Correspondence)
Pages: 169-169
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